Spread into Peritoneal

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Claudine
Posts: 267
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Spread into Peritoneal

Postby Claudine » Wed Feb 12, 2020 5:06 pm

I just got an email from OncLive with this link, that may be of interest to you nzjez:

https://www.onclive.com/conference-cove ... n-braf-crc
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT radiation 04/18, SBRT 02/19
Resection small intestine 05/18 (no cancer found - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin since 03/19
6.7 cm left adrenal mass 03/19, 3.67 cm 12/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 10.2
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: 2 calcified granulomas, one 1mm stable nodule

4us4
Posts: 8
Joined: Tue Aug 13, 2019 2:58 pm
Location: Oregon USA

Re: Spread into Peritoneal

Postby 4us4 » Fri Feb 14, 2020 1:20 pm

nzjez wrote:So all went well enough for my Cytoreductive surgery with HIPEC on the 9th Nov. My surgery was an open surgery (there was mention initially of laparoscopic being possible), and took under 6 hours (including the HIPEC).


Just a note to say I had HIPEC and Cytoreducutive on 11/7/19. Almost twins!
DX@39yo in April 2019: Stage 4 Sigmoid-spread to peritoneum, both ovaries, spleen
June-Oct 2019: FOLFOX, Avastin, 5FU (9 infusions)
Nov 2019: Cytoreductive+HiPEC at UCSD, PCI score= 8
Jan2020: FOLFOX, Avastin, 5FU (3 infusions)
Next: LIVE!

Married w/2 boys 4yo & 1yo, Live at the Oregon Coast, Solid in my faith & firmly believe that WHATEVER the future holds, God is with me & THAT is enough... while praying my socks for full recovery & chance to raise my kids to adulthood.

Rock_Robster
Posts: 454
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Spread into Peritoneal

Postby Rock_Robster » Fri Feb 14, 2020 7:27 pm

Claudine wrote:I just got an email from OncLive with this link, that may be of interest to you nzjez:

https://www.onclive.com/conference-cove ... n-braf-crc

This is a good one to follow. However it is using BEACON in the second or even third-line setting so don’t pay too much attention to the absolute survival numbers. You may want to keep a close eye on ANCHOR as well as this is using the BEACON triplet in the first line / untreated patients (from your signature it doesn’t sound like you progressed on CAPOX which is good).

https://clinicaltrials.gov/ct2/show/NCT03693170

Rob
Male 37; Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+
3 LN; 4 liver mets
pT3pN1aM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0
11/18 - FOLFOX x6
3/19 - Liver resection
4-5/19 - 25 x pelvic radiation; complete met. response
07/19 - ULAR (robot), temp ileo, 1/27 LN
08/19 - Missed a liver spot
08-11/19 - FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 - Liver resection #2
02/20 - Ileostomy reversed

nzjez
Posts: 22
Joined: Sat Jan 19, 2019 12:23 pm
Facebook Username: Jeremy Macgillivray

Re: Spread into Peritoneal

Postby nzjez » Sun Feb 16, 2020 11:09 pm

Claudine wrote:I just got an email from OncLive with this link, that may be of interest to you nzjez:

https://www.onclive.com/conference-cove ... n-braf-crc


Hey Claudine
Thanks for thinking of me and posting the link. This triplet/doublet regimen sounds like they way forward.
Cheers
Jeremy
Male, Dx 39
Stage 4c (T3N2bM1c 21/47 LNs)
BRAF mutation KRAS wild type
2018-11 - Colon resection
2018-12 - CAPOX Chemo started
2019-03 Clear CT
CEA 7/19 0.8
2019-09 PET/CT found metastasis in peritoneal
2019-10 Laparoscopy found a single peri met, CRS/HIPEC option offered.
2019-11 CRS/HIPEC surgery 3 peri mets removed.

nzjez
Posts: 22
Joined: Sat Jan 19, 2019 12:23 pm
Facebook Username: Jeremy Macgillivray

Re: Spread into Peritoneal

Postby nzjez » Sun Feb 16, 2020 11:11 pm

4us4 wrote:
nzjez wrote:So all went well enough for my Cytoreductive surgery with HIPEC on the 9th Nov. My surgery was an open surgery (there was mention initially of laparoscopic being possible), and took under 6 hours (including the HIPEC).


Just a note to say I had HIPEC and Cytoreducutive on 11/7/19. Almost twins!

Almost twins alright. I was dx at 39 too, and have 2 kids.
Hope you getting on ok, and the chemo regime is being kind
Male, Dx 39
Stage 4c (T3N2bM1c 21/47 LNs)
BRAF mutation KRAS wild type
2018-11 - Colon resection
2018-12 - CAPOX Chemo started
2019-03 Clear CT
CEA 7/19 0.8
2019-09 PET/CT found metastasis in peritoneal
2019-10 Laparoscopy found a single peri met, CRS/HIPEC option offered.
2019-11 CRS/HIPEC surgery 3 peri mets removed.

nzjez
Posts: 22
Joined: Sat Jan 19, 2019 12:23 pm
Facebook Username: Jeremy Macgillivray

Re: Spread into Peritoneal

Postby nzjez » Sun Feb 16, 2020 11:18 pm

Rock_Robster wrote:
Claudine wrote:I just got an email from OncLive with this link, that may be of interest to you nzjez:

https://www.onclive.com/conference-cove ... n-braf-crc

This is a good one to follow. However it is using BEACON in the second or even third-line setting so don’t pay too much attention to the absolute survival numbers. You may want to keep a close eye on ANCHOR as well as this is using the BEACON triplet in the first line / untreated patients (from your signature it doesn’t sound like you progressed on CAPOX which is good).

https://clinicaltrials.gov/ct2/show/NCT03693170

Rob

Hey Rob
Yeah, apart from mytomicin c in my HIPEC there has been no chemo since my CAPOX regime (after my Stage 3c hemicolectomy).
Hopefully can keep the nasties at bay, and will try and monitor results from the ANCHOR trial. Curious to know if the doublet is better from the start or 2nd/3rd line.
Cheers
Jeremy
Male, Dx 39
Stage 4c (T3N2bM1c 21/47 LNs)
BRAF mutation KRAS wild type
2018-11 - Colon resection
2018-12 - CAPOX Chemo started
2019-03 Clear CT
CEA 7/19 0.8
2019-09 PET/CT found metastasis in peritoneal
2019-10 Laparoscopy found a single peri met, CRS/HIPEC option offered.
2019-11 CRS/HIPEC surgery 3 peri mets removed.


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