Enhanced CAR-T cell activity against solid tumors

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boswind
Posts: 74
Joined: Fri Apr 11, 2014 12:04 pm

Enhanced CAR-T cell activity against solid tumors

Postby boswind » Wed Aug 28, 2019 10:08 am

I came cross a research paper, published recently in Science, by an MIT team. The team developed a vaccine that could increase the numbers of CAR-T Cells in human body by up 200 times. Therefore, it would become realistic that CAR-T cells are to kill solid tumors. They plan to start clinical trials in 1-2 years.

Link to the paper:
https://science.sciencemag.org/content/ ... siteid=sci

It seems solid tumors are more different to treat than liquid tumors. I am closely following the progress of Prof. Ronald Levy'work of Stanford University. Their cancer vaccine that made a big splash in Jan 2018 is currently only being tested in slow glowing Lymphomas, in combination of radiation.
https://www.cancer.gov/news-events/canc ... tu-vaccine
01.24.14 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.14 Completed 5-week Radia+Xeloda
05.07.14 Had surgery
02.25.15 CT showed stage 4 inoperable
03.15 - 08.15, folfox + Avastin
08.15 - 07.17, 5FU+leucovorin+Avastin
07.17 - 01.18, Folfuri + Avastin
02.18 - 03.19, Centuximab + Irinotecan
03.19 - 05.19, Keytruda
05.19 - 9.19, Folfox+Avastin
10.19 -01.20: Centuximab+Irinotecan
03.20 - 06.20: STIVARGA
07.20 - present: lonsurf+Avanstin
MSS, KRAS wt, BRAF wt
131 rounds of chemos received (as of 12.31.20)

Siti
Posts: 269
Joined: Thu Aug 01, 2019 10:58 am

Re: Enhanced CAR-T cell activity against solid tumors

Postby Siti » Wed Sep 11, 2019 4:58 am

DH (54) DX on 5/7/19
Sigmoid|G3|LN:30/31|MSS|WT KRAS, NRAS, BRAF
7/19 PET distant LN para-aorta neck hip (0.5-1.5cm)
7/19 Lap resection
26/8 to 20/12/19 CAPEOX+Bev 7x
6/11/19 CT 3 cycle LN shrunk
1/20 Cap+Bev
4/20 TS-1+Bev due to bad HFS
NED 4 years
8/23 PET recurrence chest LN growing since Feb. CEA May(4.5>5.1>5.9)
9/23 Stopped Bev, CEA Sept(8.7) Radio 17x
11/23 PET 1+ supraclavicular LN, CEA (3.4>2.5)
12/23 Lymphadenectomy
1/24 Narrow margins, 1/5 +LN, 1.4cm +tissue, TMB (19)

Siti
Posts: 269
Joined: Thu Aug 01, 2019 10:58 am

Re: Enhanced CAR-T cell activity against solid tumors

Postby Siti » Wed Sep 11, 2019 5:16 am

And another here:
https://www.hopkinsmedicine.org/news/ne ... r-diseases

I am just wondering if anyone in this forum has done it or enrolled in the trial?
DH (54) DX on 5/7/19
Sigmoid|G3|LN:30/31|MSS|WT KRAS, NRAS, BRAF
7/19 PET distant LN para-aorta neck hip (0.5-1.5cm)
7/19 Lap resection
26/8 to 20/12/19 CAPEOX+Bev 7x
6/11/19 CT 3 cycle LN shrunk
1/20 Cap+Bev
4/20 TS-1+Bev due to bad HFS
NED 4 years
8/23 PET recurrence chest LN growing since Feb. CEA May(4.5>5.1>5.9)
9/23 Stopped Bev, CEA Sept(8.7) Radio 17x
11/23 PET 1+ supraclavicular LN, CEA (3.4>2.5)
12/23 Lymphadenectomy
1/24 Narrow margins, 1/5 +LN, 1.4cm +tissue, TMB (19)


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