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Enhanced CAR-T cell activity against solid tumors

Posted: Wed Aug 28, 2019 10:08 am
by boswind
I came cross a research paper, published recently in Science, by an MIT team. The team developed a vaccine that could increase the numbers of CAR-T Cells in human body by up 200 times. Therefore, it would become realistic that CAR-T cells are to kill solid tumors. They plan to start clinical trials in 1-2 years.

Link to the paper:
https://science.sciencemag.org/content/ ... siteid=sci

It seems solid tumors are more different to treat than liquid tumors. I am closely following the progress of Prof. Ronald Levy'work of Stanford University. Their cancer vaccine that made a big splash in Jan 2018 is currently only being tested in slow glowing Lymphomas, in combination of radiation.
https://www.cancer.gov/news-events/canc ... tu-vaccine

Re: Enhanced CAR-T cell activity against solid tumors

Posted: Wed Sep 11, 2019 4:58 am
by Siti

Re: Enhanced CAR-T cell activity against solid tumors

Posted: Wed Sep 11, 2019 5:16 am
by Siti
And another here:
https://www.hopkinsmedicine.org/news/ne ... r-diseases

I am just wondering if anyone in this forum has done it or enrolled in the trial?