Enhanced CAR-T cell activity against solid tumors

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boswind
Posts: 67
Joined: Fri Apr 11, 2014 12:04 pm

Enhanced CAR-T cell activity against solid tumors

Postby boswind » Wed Aug 28, 2019 10:08 am

I came cross a research paper, published recently in Science, by an MIT team. The team developed a vaccine that could increase the numbers of CAR-T Cells in human body by up 200 times. Therefore, it would become realistic that CAR-T cells are to kill solid tumors. They plan to start clinical trials in 1-2 years.

Link to the paper:
https://science.sciencemag.org/content/ ... siteid=sci

It seems solid tumors are more different to treat than liquid tumors. I am closely following the progress of Prof. Ronald Levy'work of Stanford University. Their cancer vaccine that made a big splash in Jan 2018 is currently only being tested in slow glowing Lymphomas, in combination of radiation.
https://www.cancer.gov/news-events/canc ... tu-vaccine
01.24.14 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.14 Completed 5-week Radia+Xeloda
05.07.14 Had surgery
02.25.15 CT showed liver and L4 Spine involvement.
03 - 08.15, folfox + Avastin
08 - 07.17, 5FU + leucovorin + Avastin for Maintenance
07 - 01.18, Folfuri + Avastin
02.07.18 - 03.06.19, Centuximab + Irinotecan
90 rounds of chemos received (as of 12.27.18)
MSS, KRAS wild type, BRAF wild type
TMB = 12 mut/MB
03.14.19 - Keytruda
05.16.19 - Folfox + Avastin

Siti
Posts: 46
Joined: Thu Aug 01, 2019 10:58 am

Re: Enhanced CAR-T cell activity against solid tumors

Postby Siti » Wed Sep 11, 2019 4:58 am

Wife of DH (54) DX on 5/7/19
CEA value: 1.2
T loc: Sigmoid
T type: Adenocarcinoma
T grade: G3
Pos LNs: 30/31
Wild type | BRAF normal
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 9

Siti
Posts: 46
Joined: Thu Aug 01, 2019 10:58 am

Re: Enhanced CAR-T cell activity against solid tumors

Postby Siti » Wed Sep 11, 2019 5:16 am

And another here:
https://www.hopkinsmedicine.org/news/ne ... r-diseases

I am just wondering if anyone in this forum has done it or enrolled in the trial?
Wife of DH (54) DX on 5/7/19
CEA value: 1.2
T loc: Sigmoid
T type: Adenocarcinoma
T grade: G3
Pos LNs: 30/31
Wild type | BRAF normal
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 9


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