Starting Capox tomorrow

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_Jelen90
Posts: 23
Joined: Sat Jan 19, 2019 7:12 pm

Starting Capox tomorrow

Postby _Jelen90 » Wed Aug 14, 2019 6:15 pm

Hi everyone,

My hubby is starting mop up Capox tomorrow and I would like some advice or just hear from someone who had the same type of chemo.

Is it very different from Folfox? What side effects did you have ?

He is a very active guy and recovered pretty well/fast from his APR surgery. He is finally feeling really good and able to work out and do more physical stuff. Were you able to stay active during chemo or it was too much ?

He is having 6 cycles, which cycle did you start getting more side effects?
21/12/2018 DH 28 diag. Rectal cancer
T2N1M0 - Stage IIIA
6 weeks of Chemorad Jan-March 2019
APR surgery June 2019
Permanent colostomy
Path report : tumor completely gone but 1 lymph node out of 8 tested positive
6 rounds of Mop up XELOX August 2019
NED December 2019

NHMike
Posts: 2363
Joined: Fri Jul 21, 2017 3:43 am

Re: Starting Capox tomorrow

Postby NHMike » Wed Aug 14, 2019 8:52 pm

Side effects:

Sensitivity to cold, all over the body. Fortunately it's summer now.
Tingling/neuropothy in the toes
Nausea a few days after infusion - they give you anti-nausea drugs at infusion time but the wear off after a few days
Arthritis in the fingers
Discoloration of skin
Fatigue
Pain when biting on food for the first time
Diarrhea around infusions
Cramps due to loss of electrolytes
Fell down the stairs two times at night because of the neuropathy and not being able to feel the edge of the stair.

Here's my diary starting with where I started CapeOx:

http://coloncancersupport.colonclub.com ... &start=480
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

margiej
Posts: 91
Joined: Sat Apr 14, 2018 8:46 am

Re: Starting Capox tomorrow

Postby margiej » Wed Aug 14, 2019 9:16 pm

I found the cold sensitivity unfun but bearable. The oxy portion was manageable but the thing that kicked my ass was nausea. Taking the capecetabine every day got more and more difficult as the two weeks went on. I felt worse on my week off. I think my case was extreme but I would do everything possible to counter the nausea. Marijuana or CBD would have helped a lot, I think, but those weren't really available to me at the time. I recommend them! Also get the best anti-nausea meds from his oncologist. He should do his best to stay hydrated.. It helps everything.
I think many people are able to stay active on this chemo regimen and I hope your husband will also.
Sending you both all the best.
Margie
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/17
CT 10/3/17 clear
CT 10/17/18 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

User avatar
Jacques
Posts: 579
Joined: Sun Dec 28, 2014 10:38 am
Location: Occitanie

Re: Starting Capox tomorrow

Postby Jacques » Wed Aug 14, 2019 10:49 pm

NHMike wrote:...
Here's my diary starting with where I started CapeOx:

viewtopic.php?f=1&t=58447&start=480

NHMike -

FYI, your CapeOx sessions started around 11 o'clock on December 20, 2017. Your first post after the start of your first CapeOx infusion was this one:

http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=58447&p=469179#p469179

The link that you gave above may not lead to this post for all users. Your link may work for you, but some users may have established a different set of display preferences, in which case your link will end up displaying posts in a different month and different year for them.
.
Display Preferences
http://coloncancersupport.colonclub.com/ucp.php?i=ucp_prefs&mode=view

I would suggest that you use a "post bookmark" rather than a "topic bookmark" whenever you want viewers to see a specific post in your thread.

The link you gave above is a "topic bookmark" with an offset of 480 messages. This kind of bookmark will only work correctly for users who have set their user preferences the same way as yours.

The procedure for creating universal post bookmarks is described here:

http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=38032&p=487386#p487386

TinaFish
Posts: 178
Joined: Sun Jul 21, 2019 10:11 am

Re: Starting Capox tomorrow

Postby TinaFish » Thu Aug 15, 2019 12:24 am

Dude, you should read my "Diarrhea and bloating and gas" thread. I just had my 3rd round of chemo. I'm on Capeox. I didn't have any nausea until the 5th and 6th days after my 3rd round of chemo. I was surprised that the nausea didn't come on until the 3rd round. It wasn't too bad, though.

I took three prescription anti-nausea pills at once yesterday evening, after I was fed up with being nauseous all day long and angry that the "suggested" dose of one pill hadn't done anything for me earlier yesterday. The three pills worked great, and I haven't been nauseous since. So today was pretty good. I had my oxaliplatin exactly one week ago and I've been taking the Capecitabine pills since then, although with my diarrhea/cramping/gas side effects, my oncologist told me to take a couple days off from the Capecitabine.

And you know what really helped me feel great last night after straining in vain to poop all day long, and with sore rectal muscles and just a feeling of shittiness? I took a Norco. I've never been a pill popper, much less an opiate pill popper, but I gave myself permission. The Norco made me feel perrrrrrfect ;)
Last edited by TinaFish on Thu Aug 15, 2019 12:29 am, edited 1 time in total.
F 45, single mother to son, 7 and daughter, 3
DX: stage 4 Rectal Cancer June 2019
Tumor Location: ? cm above anal verge
Tumor type: Adenocarcinoma
Tumor size: 5 cm
Tumor grade: ?
TNM code: ?
Stage : Stage IV-B
# of cancerous lymph nodes: ?
Mets: Numerous mets to liver, lungs
CEA: 22 in July; 11 as of August 15, 7 as of Sept 20
MSI status: MSS
KRAS/BRAF status: KRAS mutation
surgery: TBD
Ostomy surgery: TBD
Radiation therapy: TBD
Chemotherapy : CAPEOX+Avastin, 6 cycles, with CT scans after 3rd and 6th cycle.

User avatar
Jacques
Posts: 579
Joined: Sun Dec 28, 2014 10:38 am
Location: Occitanie

Common side effects of XELOX (CAPEOX)

Postby Jacques » Thu Aug 15, 2019 12:28 am


NHMike
Posts: 2363
Joined: Fri Jul 21, 2017 3:43 am

Re: Starting Capox tomorrow

Postby NHMike » Thu Aug 15, 2019 3:12 pm

I'll be more careful with direct links and verify them.

On activity - it is challenging if you're doing everything else normally too because of the fatigue and the time dealing with the temp ileostomy (I'm assuming that your husband has one of these - if he doesn't, then things are simpler).

I did run and walk a lot during chemo. In the last month of chemo I was doing 100 miles per week. That was overkill but I was in a steps contest.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

DarknessEmbraced
Posts: 3396
Joined: Sat Nov 01, 2014 4:54 pm
Facebook Username: Riann Fletcher
Location: New Brunswick, Canada

Re: Starting Capox tomorrow

Postby DarknessEmbraced » Tue Aug 27, 2019 12:58 pm

I hope his chemo goes well!*hugs*
Diagnosed 10/28/14, age 36
Colon Resection 11/20/14, LAR (no illeo)
Stage 2a colon cancer, T3NOMO
Lymph-vascular invasion undetermined
0/22 lymph nodes
No chemo, no radiation
Clear Colonoscopy 04/29/15
NED 10/20/15
Ischemic Colitis 01/21/16
NED 11/10/16
CT Scan moved up due to high CEA 08/21/17
NED 09/25/17
NED 12/21/18
Clear colonoscopy 09/23/19
Clear 5 year scans 11/21/19- Considered cured! :)

Siti
Posts: 115
Joined: Thu Aug 01, 2019 10:58 am

Re: Starting Capox tomorrow

Postby Siti » Wed Aug 28, 2019 4:37 pm

My husband started CAPOX + Avastin 3 days ago and is doing well. He runs / goes to the gym every morning and evening walks in the park. So far his main side effects are sensitive to the cold (throat and touch) and tooth ache when chewing for the first time.
Wife of DH (54) DX on 5/7/19
CEA value: 1.2
T loc: Sigmoid
T type: Adenocarcinoma
T grade: G3
Pos LNs: 30/31
Wild Type for KRAS, NRAS and BRAF
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 9
6/11/19 CT Scan after 3rd cycle, all nodes have shrunk! Yay!!


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