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Good news on Triplet Therapy

Posted: Tue Aug 06, 2019 4:30 pm
by hopefulandstrong
For those of you with the BRAF mutation considering triplet therapy, I want to report that since starting this therapy in mid-May, my CEA dropped from 214 to 2.8, and all liver 4 mets have shrunk -- all are 3.5 cm or below now. Shrinkage at this point is about 30%. My side effects -- nausea, fatigue, rash -- have been completely manageable. I'm lucky that I work largely at home, so can nap when needed.

Headed to MSK tomorrow for another consult -- we'll see if pump is the next step. Curious to know if any of you have seen tumors continue to shrink on meds. Happy to answer further questions for those of you considering the Triplet.

Re: Good news on Triplet Therapy

Posted: Tue Aug 06, 2019 8:23 pm
by fumaros
Thats some amazing developing and in such a short time. I haven't heard of triplet therapy before, is it confined to certain tumor characteristics?

Re: Good news on Triplet Therapy

Posted: Wed Aug 07, 2019 7:45 am
by LeonW
Hi Hope

Congrats on your response - that your liver mets shrunk that much in 3 months time is really good news. Have a look at my sign below. FWIW, there are a few similarities that you may find encouraging: we both have/had a transverse colon resect immediately following Dx - ahead of attacking the liver mets that seem to respond so well to the meds. And your nice CEA readings seem to reflect what's happening in the liver. You may well be one of the lucky ones for whom CEA is a good indicator of cancer activity.

hopefulandstrong wrote:. . . Curious to know if any of you have seen tumors continue to shrink on meds.
My docs started out with CAPOX-Avastine right from the beginning, with shrinkage from week 10 which is quite comparable to your shrinkage of 30% at month 3.

I haven't heard of your EBC/triplet therapy, but it looks pretty effective, so far. Is it one of the new targeted treatments, may be?

I completed all the planned (8) rounds of CAPOX and may have been going into the liver surgery clean of cancer, as pathology couldn't find any living cancer cells in the piecesremoved. Have been NED with stable/low CEAs since (Oct 2013). I wish you to do similarly.

Regards, Leon

Re: Good news on Triplet Therapy

Posted: Wed Aug 07, 2019 6:08 pm
by hopefulandstrong
Thanks friends -

Just came from MSK consult. Plan is to do a couple more months as is and then consider resection. An earlier scan suggested possible peri mets, but the latest contradicts -- saying what is seen is scar tissue from surgery. I think if my onc is convinced the disease is confined to liver, she will be more enthusiastic about surgery.

Leon, she also confirmed that finding necrotic tissue in the spaces that show up as lesions is more common than some think. I think CEA may be a good indicator for me.

The Triplet Therapy is new -- targeted especially for BRAF 7600 folks like me. Though, I'm also understanding that there are varieties of BRAF'ness. Crossing my fingers that my version may a teeny bit less virulent than some others. In any case, this response is such a relief as Folfox failed for me.

Re: Good news on Triplet Therapy

Posted: Thu Aug 08, 2019 1:14 pm
by boxhill
Congratulations, that is excellent news!