Metformin is usually prescribed for T2 diabetes, and it is NOTORIOUS for causing diarrhea, and in some cases a lot of gas!!!!!! It has been nicknamed Metfartin. Metformin probably isn't going to do anything involving your tumor's "pathways," what it does is discourage the liver from dumping glucose into the blood, thus helping to control blood glucose levels. It would appear that they are prescribing this to you on the theory that blood sugar feeds cancer.
That's all very well and good, but I can assure you that I would not be taking it if I didn't actually need it to help control my BG because of T2, because DIARRHEA. For YEARS. What dose are you taking? MANY, and I mean MANY people can't tolerate it.
What is the rationale for taking atorvastatin? Do you have high cholesterol? What dose are you taking? What is the rationale for taking an antibiotic? Both of those drugs have diarrhea as a common side effect. I've read about the worm med guy. It's not clear to me whether his personal results have been duplicated or studied seriously. I wouldn't dismiss it, but...
Your onc may have cast an eye over this list and decided that if you wanted to try it it would be unlikely to do you any serious harm, since they are doing frequent blood tests, as one must on chemo.
But given the extreme nature of your diarrhea, I think you should immediately quit taking metformin, at least. If you want to control your BG levels, get a testing kit and start limiting your carbs. Metformin is also somewhat of an issue for those having scans with contrast, since the combo can put a strain on the kidneys.
What you are doing is piling more and more drugs into your system, all of which have to be dealt with by your liver and kidneys. I seriously think you should rethink this.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
7/9/18 CT NED
11/20/18 CT NED. Enlarged spleen.
12/20/18 Liver MRI 5mm liver met? and 2 lymph nodes in porta hepatis
6/5/19 Triphasic CT LN and spleen normal, Liver node stable
6/28/19 Pause Keytruda, predisone for joint pain
7/31/19 Restart Keytruda
9/10/19 CT stable