Got the results in mychart:
Went from 4.5 x 3.7 to 3.6 x 2.3!
I have no idea how significant a change that is but I'll take it!
CT shows my liver met is SMALLER!!
CT shows my liver met is SMALLER!!
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
-
Gravelyguy
- Posts: 382
- Joined: Thu Jul 05, 2018 6:03 pm
Re: CT shows my liver met is SMALLER!!
That is awesome news Amy. Shrinking tumors is alway significant in my book!
Dave
Dave
6/17 dx mRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm
6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 CEA .9 still NED!
6/11/19 CEA 1.0
12/19/19 CEA 1.0 still NED!
6/17/20 CEA 1.1 still NED!
12/15/20 CEA 1.1still NED!
12/16/21 CEA 1.2 still NED!
6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 CEA .9 still NED!
6/11/19 CEA 1.0
12/19/19 CEA 1.0 still NED!
6/17/20 CEA 1.1 still NED!
12/15/20 CEA 1.1still NED!
12/16/21 CEA 1.2 still NED!
-
Rock_Robster
- Posts: 1028
- Joined: Thu Oct 25, 2018 5:27 am
- Location: Brisbane, Australia
Re: CT shows my liver met is SMALLER!!
That’s awesome news, AmyG!
Based just on the longest measurement alone, that’s a 20% reduction which is very nice. However based on area visible on a 2D scan it’s more like a 50% reduction!
And because of geometry fun, what you’ve quoted could correspond to up to ~60% reduction in tumour volume! (I’ve had to make an assumption there as one dimension is missing).
This is overall similar to (or a bit better than) my response after 4 FOLFOX rounds, and both I and my oncologist were very happy with that. When they subsequently resected the lesions, the tumour tissue was between 40% - 80% dead.
Aside from shrinkage before surgery, one of the more important parts of this treatment is to confirm that your tumour biology is sensitive to the chemo, and thus a good chance of having ‘systemic control’. I’m no oncologist but I’d find this very encouraging.
Based just on the longest measurement alone, that’s a 20% reduction which is very nice. However based on area visible on a 2D scan it’s more like a 50% reduction!
And because of geometry fun, what you’ve quoted could correspond to up to ~60% reduction in tumour volume! (I’ve had to make an assumption there as one dimension is missing).
This is overall similar to (or a bit better than) my response after 4 FOLFOX rounds, and both I and my oncologist were very happy with that. When they subsequently resected the lesions, the tumour tissue was between 40% - 80% dead.
Aside from shrinkage before surgery, one of the more important parts of this treatment is to confirm that your tumour biology is sensitive to the chemo, and thus a good chance of having ‘systemic control’. I’m no oncologist but I’d find this very encouraging.
Last edited by Rock_Robster on Mon Jun 24, 2019 1:10 am, edited 4 times in total.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial
Re: CT shows my liver met is SMALLER!!
Yay!!! Great news!
2008, Stage 3C, age 42, mom of 4
Folfox 9/08-2/09
Met to right ovary, both removed 7/10
HIPEC 8/10
VATS 7/12, right lung
10/14 Stivarga clinical trial
3/15-7/15 Folfiri & avastin
8/16 Folfiri & avastin
Break! 10 months of freedom
1/18 - 4/23 many Folfiri & Avastin
6/23 Clinical trial REGN7075. Progression
8/23 radiation to femurs and L4
9/23 rechallenged Folfox. Allergic reaction at 4th infusion
11/23 will start Bot/Bal
Folfox 9/08-2/09
Met to right ovary, both removed 7/10
HIPEC 8/10
VATS 7/12, right lung
10/14 Stivarga clinical trial
3/15-7/15 Folfiri & avastin
8/16 Folfiri & avastin
Break! 10 months of freedom
1/18 - 4/23 many Folfiri & Avastin
6/23 Clinical trial REGN7075. Progression
8/23 radiation to femurs and L4
9/23 rechallenged Folfox. Allergic reaction at 4th infusion
11/23 will start Bot/Bal
-
SilverWedding
- Posts: 71
- Joined: Sat May 18, 2019 5:54 am
- Facebook Username: Cynthia Harding Marshall
Re: CT shows my liver met is SMALLER!!
Great news! So encouraging!
DH, 56, Sigmoid & rectum
Adenocarcinoma 2cm G2: Moderately differentiated
T3N2aM0
Stage IIIb
LN 6/22
5/19 Baseline CEA value - 18.9
Lymphovascular invasion (LVI): present
Perineural invasion (PNI): not identified
Surgical margins: proximal -negative; distal - negative 1.5cm; circumferential - negative 1mm)
MSI status: Waiting
Lynch status: ?
KRAS/BRAF: ?
Open Restorative Proctectomy, J-Pouch Coloanal Anastomosis, Loop Ileo w/Appendectomy
Neo-adjuvant Xeloda/radiation
Adjuvant Chemo: to begin 11/19
Adenocarcinoma 2cm G2: Moderately differentiated
T3N2aM0
Stage IIIb
LN 6/22
5/19 Baseline CEA value - 18.9
Lymphovascular invasion (LVI): present
Perineural invasion (PNI): not identified
Surgical margins: proximal -negative; distal - negative 1.5cm; circumferential - negative 1mm)
MSI status: Waiting
Lynch status: ?
KRAS/BRAF: ?
Open Restorative Proctectomy, J-Pouch Coloanal Anastomosis, Loop Ileo w/Appendectomy
Neo-adjuvant Xeloda/radiation
Adjuvant Chemo: to begin 11/19
Re: CT shows my liver met is SMALLER!!
Woohoo!
Caregiver to my amazing mom (68 at dx)
10/1/18 DX with rectal cancer; CEA 17
T3N2M0
Total neoadjuvant therapy:
8 rounds Folfox 11/5/18 - 2/11/19
Short course radiation 3/14/19 - 3/20/19
Robotically assisted laparoscopic LAR 3/21/19
Pathology report says yT2N0M0 with 0/38 nodes
6/28/19 Reversal and port out
CEA 2.1; 1.9; 2.6; 2.8; 2.3; 2.4; 3.0; 3.4; 3.1; 3.4; 3.0; 3.1; 2.6
Latest update: 8/21/23 Clear CT with CEA 2.6!
Me: 34, first colonoscopy 11/16/18—normal! Come back in 5 years.
10/1/18 DX with rectal cancer; CEA 17
T3N2M0
Total neoadjuvant therapy:
8 rounds Folfox 11/5/18 - 2/11/19
Short course radiation 3/14/19 - 3/20/19
Robotically assisted laparoscopic LAR 3/21/19
Pathology report says yT2N0M0 with 0/38 nodes
6/28/19 Reversal and port out
CEA 2.1; 1.9; 2.6; 2.8; 2.3; 2.4; 3.0; 3.4; 3.1; 3.4; 3.0; 3.1; 2.6
Latest update: 8/21/23 Clear CT with CEA 2.6!
Me: 34, first colonoscopy 11/16/18—normal! Come back in 5 years.
-
lovelife789
- Posts: 161
- Joined: Thu Aug 24, 2017 5:28 am
Re: CT shows my liver met is SMALLER!!
I'm soooooo happy for you! I know that feeling 
let's kick those cancer cells hard!!!
let's kick those cancer cells hard!!!F/38 - Dx 8 Mar 17, CEA 189.5
Stage IV Sig. Colon, Liver mets, T3N0M1a, KRAS NRAS Wild
3/17- 6/17 - 6 x FOLFOX + Erbitux
7/17 - 1st & 2nd Liver resec
9-12/17' - 13 x FOLFOX
1-6/18 - NED
6/18 - PET SCAN showed a 0.8mm lung nodule, VATs
8/18 - 4/19 - NED
5/19 - recurrence 1 x PALN, 1x common iliac
FOLFIRI + Avastin x 12 - complete response, SBRT
12/19-5/20 - NED
5/20 - recurrence in LNs, tiny liver spots x 2, W n W due to COVID
8/20 - LNs very slightly increased, liver stable, one new liver spot
Stage IV Sig. Colon, Liver mets, T3N0M1a, KRAS NRAS Wild
3/17- 6/17 - 6 x FOLFOX + Erbitux
7/17 - 1st & 2nd Liver resec
9-12/17' - 13 x FOLFOX
1-6/18 - NED
6/18 - PET SCAN showed a 0.8mm lung nodule, VATs
8/18 - 4/19 - NED
5/19 - recurrence 1 x PALN, 1x common iliac
FOLFIRI + Avastin x 12 - complete response, SBRT
12/19-5/20 - NED
5/20 - recurrence in LNs, tiny liver spots x 2, W n W due to COVID
8/20 - LNs very slightly increased, liver stable, one new liver spot
Re: CT shows my liver met is SMALLER!!
Awesome. Keep up the positive cancer killing vibes.
DH to 38 wife w/kids
Stage 3C DX 3/3/17 CEA 29
5-fu and radiation ended May 17, 2017
Stage 4 External iliac node July 17, 2017
FOLFOX + Avistan July 18 2017 CEA 2.3
Nov 9, 2017 Coloanal Anastomosis, Hysterectomy & External Nodes Removed W/ileostomy
Clear Margins NED
CEA 1.5 12/17, 2.1 2/18, 2.3 6/18, 1.1 9/18, 1.3 12/18, 1.8 3/19, 2.5 6/19
Clear CT and MRI on 2/5/2018, 9/18 Clear Scans
Reversal Surgery 6/26/18
Small Spot on right ureter surgery 10/30/19 adhered to artery
Dec. 2 start 12 rounds FOLFIRI
Stage 3C DX 3/3/17 CEA 29
5-fu and radiation ended May 17, 2017
Stage 4 External iliac node July 17, 2017
FOLFOX + Avistan July 18 2017 CEA 2.3
Nov 9, 2017 Coloanal Anastomosis, Hysterectomy & External Nodes Removed W/ileostomy
Clear Margins NED
CEA 1.5 12/17, 2.1 2/18, 2.3 6/18, 1.1 9/18, 1.3 12/18, 1.8 3/19, 2.5 6/19
Clear CT and MRI on 2/5/2018, 9/18 Clear Scans
Reversal Surgery 6/26/18
Small Spot on right ureter surgery 10/30/19 adhered to artery
Dec. 2 start 12 rounds FOLFIRI
Re: CT shows my liver met is SMALLER!!
Rock_Robster wrote:That’s awesome news, AmyG!
Based just on the longest measurement alone, that’s a 20% reduction which is very nice. However based on area visible on a 2D scan it’s more like a 50% reduction!
And because of geometry fun, what you’ve quoted could correspond to up to ~60% reduction in tumour volume! (I’ve had to make an assumption there as one dimension is missing).
This is overall similar to (or a bit better than) my response after 4 FOLFOX rounds, and both I and my oncologist were very happy with that. When they subsequently resected the lesions, the tumour tissue was between 40% - 80% dead.
Aside from shrinkage before surgery, one of the more important parts of this treatment is to confirm that your tumour biology is sensitive to the chemo, and thus a good chance of having ‘systemic control’. I’m no oncologist but I’d find this very encouraging.
I love your math!!! Waiting on labs, then off to see the oncologist. Then we start round #5! Afaik, I'm getting CEA drawn today too.
So pleased to hear you had such a good response, I'm hoping when they get to my liver, there's not much tumor left.
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
-
brokenwings
- Posts: 147
- Joined: Mon Jan 07, 2019 1:50 am
Re: CT shows my liver met is SMALLER!!
Excellent news, Amy! Keep fighting!
DX 2019 Adenocarcinoma Sigmoid colon. PC + ovarian met.
Obstruction. Temporary colostomy.
Folfirinox + Avastin: 6 cycles. Scans: partial response.
Surgery (CRS + HIPEC) 04/29: too much disease, surgery cancelled. Right ovary removed.
2nd ptotocol: IP chemo (oxaliplatin) + IV chemo (Folfiri + Avastin). 8 cycles
10/31/2019: 11 hour-long Hipec + 6 weeks in hospital
12/30/2019: liver met
02/05/2020: reversal surgery. New peri mets discovered
March 2020: 5fu+Avastin
May 2020: fistula
Back to 1957: 5fu.
Obstruction. Temporary colostomy.
Folfirinox + Avastin: 6 cycles. Scans: partial response.
Surgery (CRS + HIPEC) 04/29: too much disease, surgery cancelled. Right ovary removed.
2nd ptotocol: IP chemo (oxaliplatin) + IV chemo (Folfiri + Avastin). 8 cycles
10/31/2019: 11 hour-long Hipec + 6 weeks in hospital
12/30/2019: liver met
02/05/2020: reversal surgery. New peri mets discovered
March 2020: 5fu+Avastin
May 2020: fistula
Back to 1957: 5fu.
-
ginabeewell
- Posts: 565
- Joined: Wed Oct 24, 2018 10:30 am
Re: CT shows my liver met is SMALLER!!
That sounds like a significant reduction to me!
The only advice I would share is to make sure you and your doctors are looking closely for a plateau. In retrospect, I think we should have seen signs of plateauing much sooner than we did, and if we had, we might have moved forward to surgery more quickly. So just keep an eye on things. And if you haven't had a surgical consult yet, do it sooner versus later.
I'm guessing your CEA will decline as well. Keep us posted!
The only advice I would share is to make sure you and your doctors are looking closely for a plateau. In retrospect, I think we should have seen signs of plateauing much sooner than we did, and if we had, we might have moved forward to surgery more quickly. So just keep an eye on things. And if you haven't had a surgical consult yet, do it sooner versus later.
I'm guessing your CEA will decline as well. Keep us posted!
49 YO mom of twins (11) lucky stepmom of 16/19 year olds
9/17/18 DX stage 4 CRC w inoperable liver mets CEA 931
Currently NED!
Join me on a lookback of my journey via my Strive for Five on Substack here:
https://ginajacobson.substack.com
All treatment details here:
https://www.weareallmadeofstars.net/col ... nt-journey
My favorite posts here:
https://weareallmadeofstars.net/favorite-posts
9/17/18 DX stage 4 CRC w inoperable liver mets CEA 931
Currently NED!
Join me on a lookback of my journey via my Strive for Five on Substack here:
https://ginajacobson.substack.com
All treatment details here:
https://www.weareallmadeofstars.net/col ... nt-journey
My favorite posts here:
https://weareallmadeofstars.net/favorite-posts
Re: CT shows my liver met is SMALLER!!
Oncologist was pleased, she called me amazing. Might do a little bit more chemo before resection to shrink it more.
CT scheduled for 7/17 and that should help them determine when they want to cut that f'ing thing out.
Currently waiting in the lobby to do cycle 5. No CEA results in mychart yet. I've had awful diarrhea since Tuesday, so they made me give them a stool sample. Guess who doesn't have water pouring out her backside anymore? Of course not. Just like I don't have a bleed anymore.
Bodies are dumb.
CT scheduled for 7/17 and that should help them determine when they want to cut that f'ing thing out.
Currently waiting in the lobby to do cycle 5. No CEA results in mychart yet. I've had awful diarrhea since Tuesday, so they made me give them a stool sample. Guess who doesn't have water pouring out her backside anymore? Of course not. Just like I don't have a bleed anymore.
Bodies are dumb.
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
Re: CT shows my liver met is SMALLER!!
AmyG wrote:Bodies are dumb.
BUTT shrinkage is good ....
and your attitude kicks BUTT
keep on rockin' sista
keep on rockin'
Cheers and Harmony
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far
Re: CT shows my liver met is SMALLER!!
CEA is down to 24!!!!!!!!
Omfg, this is awesome. Went from 167 when I started chemo, to 98 to 20 freaking 4. Yall, I'm stoked.
Omfg, this is awesome. Went from 167 when I started chemo, to 98 to 20 freaking 4. Yall, I'm stoked.
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!! CEA 2.3
CEA 5.8 idk wtf is up with that, but everything else is clear!
CEA 3.7 make up your damn mind...
CEA 1.5 that's a new low!
Re: CT shows my liver met is SMALLER!!
AmyG wrote:CEA is down to 24!!!!!!!!
Omfg, this is awesome. Went from 167 when I started chemo, to 98 to 20 freaking 4. Yall, I'm stoked.
Great News! Hurray
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung NED again Oct-19
Steroid induced hyperglycemia dx after 3chemo
Surgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb & Oct lung mets
Adenocarcenoma 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung NED again Oct-19
Steroid induced hyperglycemia dx after 3chemoSurgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb & Oct lung mets
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