CT shows my liver met is SMALLER!!

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AmyG
Posts: 244
Joined: Tue Dec 25, 2018 8:08 pm

CT shows my liver met is SMALLER!!

Postby AmyG » Sun Jun 23, 2019 8:45 pm

Got the results in mychart:

Went from 4.5 x 3.7 to 3.6 x 2.3!

I have no idea how significant a change that is but I'll take it!
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!!

Gravelyguy
Posts: 199
Joined: Thu Jul 05, 2018 6:03 pm

Re: CT shows my liver met is SMALLER!!

Postby Gravelyguy » Sun Jun 23, 2019 8:55 pm

That is awesome news Amy. Shrinking tumors is alway significant in my book!

Dave
6/17 dx mCRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0

Rock_Robster
Posts: 282
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: CT shows my liver met is SMALLER!!

Postby Rock_Robster » Sun Jun 23, 2019 9:43 pm

That’s awesome news, AmyG!

Based just on the longest measurement alone, that’s a 20% reduction which is very nice. However based on area visible on a 2D scan it’s more like a 50% reduction!

And because of geometry fun, what you’ve quoted could correspond to up to ~60% reduction in tumour volume! (I’ve had to make an assumption there as one dimension is missing).

This is overall similar to (or a bit better than) my response after 4 FOLFOX rounds, and both I and my oncologist were very happy with that. When they subsequently resected the lesions, the tumour tissue was between 40% - 80% dead.

Aside from shrinkage before surgery, one of the more important parts of this treatment is to confirm that your tumour biology is sensitive to the chemo, and thus a good chance of having ‘systemic control’. I’m no oncologist but I’d find this very encouraging.
Last edited by Rock_Robster on Mon Jun 24, 2019 1:10 am, edited 4 times in total.
Male 37; Melbourne, Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+ PNI-
3 LN; 4 liver mets, resectable
pT3pN1apM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0
11/18 - FOLFOX x 6
3/19 - Liver resection
4-5/19 - 25 x pelvic radiation; complete met. response, TRG 3
07/19 - ULAR (robot), temp ileo, 1/27 LN+
08/19 - Missed liver spot
08/19 - FOLFOX x 1, FOLFOXIRI x 1, FOLFIRI x 2
10/19 - Planned liver resection #2 & ileo reversal

debb
Posts: 176
Joined: Sun Dec 21, 2008 9:03 pm
Location: NJ

Re: CT shows my liver met is SMALLER!!

Postby debb » Sun Jun 23, 2019 10:08 pm

Yay!!! Great news!
Stage 3C, Dx at 42, mom of 4
Colon resection 7/08
Folfox 9/08-2/09
Met to right ovary, both ovaries removed 7/10
HIPEC 8/10
VATS 7/12, 2 nodes, right lung
10/14 3 lung nodes, Stivarga clinical trial
3/15-7/15 Folfiri & avastin for lung things
Break! One+ year of freedom
8/16 Folfiri & avastin..lung things again
Break! 10 months of freedom
1/18 rib mets, radiation, folfiri & avastin
1/19 rib mets again, radiation, folfiri & avastin

User avatar
SilverWedding
Posts: 48
Joined: Sat May 18, 2019 5:54 am
Facebook Username: Cynthia Harding Marshall

Re: CT shows my liver met is SMALLER!!

Postby SilverWedding » Sun Jun 23, 2019 10:14 pm

Great news! So encouraging!
5/19 - DH - 50s, RC 5+cm at dentate line extending to rectal vau
5/19 - No spread to liver/lungs, but 4 swollen lymph nodes
6/19 - Stage III
6/19 - Neoadjuvant Xeloda with radiation 6 weeks
9/19 will be first surgery

Punky44
Posts: 349
Joined: Mon Oct 01, 2018 4:29 pm

Re: CT shows my liver met is SMALLER!!

Postby Punky44 » Sun Jun 23, 2019 10:18 pm

Woohoo!
Caregiver to my amazing mom (68)
10/1/18 DX with rectal cancer; CEA 17 at diagnosis
MRI/CT/PET puts staging at T3N2M0
Total neoadjuvant therapy:
8 rounds Folfox 11/5/18 - 2/11/19
Short course radiation 3/14/19 - 3/20/19
Robotically assisted laparoscopic LAR 3/21/19
Pathology report says yT2N0M0 with 0/38 nodes
CEA 4/23: 2.1; 7/24: 1.9
6/28/19 Reversal and port out

Me: 34, first colonoscopy 11/16/18—normal! Come back in 5 years.

lovelife789
Posts: 141
Joined: Thu Aug 24, 2017 5:28 am

Re: CT shows my liver met is SMALLER!!

Postby lovelife789 » Mon Jun 24, 2019 6:42 am

I'm soooooo happy for you! I know that feeling :D let's kick those cancer cells hard!!!
F/38 - Dx 8 Mar 17, CEA 189.5
Stage IV Sig. Colon, Liver mets, T3N0M1a, KRAS NRAS Wild, G2=Mod. differentiated
3/17- 6/17 - 6 rounds of FOLFOX + Erbitux - CEA 2.5
7/17 - 1st Liver resect/Colon/Gall, all clear margin
8/17 - 2nd Liver resec
9-12/17' - completed 13 rounds of FOLFOX - CEA 1.0
1/18 - 6/30 - NED
6/30 - PET SCAN showed a lung nodule that grew from 5mm to 8mm - CEA 1.0
8/30 - VATs
8/30 - 4/30 - NED
5/28 - uptake seen in 1 x PALN, 1x common iliac, cloudy in Liver
FOLFIRI + Avastin

tater
Posts: 109
Joined: Wed Jul 19, 2017 5:53 pm

Re: CT shows my liver met is SMALLER!!

Postby tater » Mon Jun 24, 2019 8:16 am

Awesome. Keep up the positive cancer killing vibes.
DH to 38 wife w/kids
Stage 3C DX 3/3/17 CEA 29
5-fu and radiation ended May 17, 2017
Stage 4 External iliac node July 17, 2017
FOLFOX + Avistan July 18 2017 CEA 2.3
Nov 9, 2017 Coloanal Anastomosis, Hysterectomy & External Nodes Removed W/ileostomy
Clear Margins NED
CEA 1.5 12/17, 2.1 2/18, 2.3 6/18, 1.1 9/18, 1.3 12/18, 1.8 3/19, 2.5 6/19
Clear CT and MRI on 2/5/2018, 9/18 Clear Scans
Reversal Surgery 6/26/18

AmyG
Posts: 244
Joined: Tue Dec 25, 2018 8:08 pm

Re: CT shows my liver met is SMALLER!!

Postby AmyG » Mon Jun 24, 2019 9:09 am

Rock_Robster wrote:That’s awesome news, AmyG!

Based just on the longest measurement alone, that’s a 20% reduction which is very nice. However based on area visible on a 2D scan it’s more like a 50% reduction!

And because of geometry fun, what you’ve quoted could correspond to up to ~60% reduction in tumour volume! (I’ve had to make an assumption there as one dimension is missing).

This is overall similar to (or a bit better than) my response after 4 FOLFOX rounds, and both I and my oncologist were very happy with that. When they subsequently resected the lesions, the tumour tissue was between 40% - 80% dead.

Aside from shrinkage before surgery, one of the more important parts of this treatment is to confirm that your tumour biology is sensitive to the chemo, and thus a good chance of having ‘systemic control’. I’m no oncologist but I’d find this very encouraging.



I love your math!!! Waiting on labs, then off to see the oncologist. Then we start round #5! Afaik, I'm getting CEA drawn today too.

So pleased to hear you had such a good response, I'm hoping when they get to my liver, there's not much tumor left.
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!!

brokenwings
Posts: 101
Joined: Mon Jan 07, 2019 1:50 am

Re: CT shows my liver met is SMALLER!!

Postby brokenwings » Mon Jun 24, 2019 10:21 am

Excellent news, Amy! Keep fighting!
DX 2019 Adenocarcinoma Sigmoid colon. PC + ovarian met.
Obstruction. Temporary colostomy. Primary tumour still there.
Folfirinox: 6 cycles
CT Scan/PET Scan: ok for surgery
Surgery (CRS + HIPEC) 04/29: not optimally resectable, surgery cancelled. Right ovary removed.
2nd ptotocol: IP chemo (oxaliplatin) + IV chemo (Folfiri + Avastin).
07/04: exploratory laparoscopy - necrosis of peri mets
4 more cycles
09/11: CT scan
09/12: last exploratory laparoscopy and final decision

User avatar
ginabeewell
Posts: 295
Joined: Wed Oct 24, 2018 10:30 am

Re: CT shows my liver met is SMALLER!!

Postby ginabeewell » Mon Jun 24, 2019 11:14 am

That sounds like a significant reduction to me!

The only advice I would share is to make sure you and your doctors are looking closely for a plateau. In retrospect, I think we should have seen signs of plateauing much sooner than we did, and if we had, we might have moved forward to surgery more quickly. So just keep an eye on things. And if you haven't had a surgical consult yet, do it sooner versus later.

I'm guessing your CEA will decline as well. Keep us posted!
45 year old mom of twins (7) and lucky stepmom of 13 and 16 year olds
9/17/18 DX stage 4 CRC w inoperable liver mets (largest 11 cm)
9/20/18 CEA 931
10/1/18 FOLFOX + Vectibix planned 12 rounds
12/12/18 Routine scan showed typhlitis (7 days in hospital) but largest met down to 5 cm. Chemo holiday.
12/26/18 CEA 4.6
1/14/18 Resume chemo (#6-8)
3/27/19 Surgery: HAI pump placement / colon resection
4/8/19 Resume chemo (#9-12) FOLFOX (no OX) + Vectibix
5/20/19 CEA 1.3
7/19/18: 1st of 2 liver resections

AmyG
Posts: 244
Joined: Tue Dec 25, 2018 8:08 pm

Re: CT shows my liver met is SMALLER!!

Postby AmyG » Mon Jun 24, 2019 11:19 am

Oncologist was pleased, she called me amazing. Might do a little bit more chemo before resection to shrink it more.

CT scheduled for 7/17 and that should help them determine when they want to cut that f'ing thing out.

Currently waiting in the lobby to do cycle 5. No CEA results in mychart yet. I've had awful diarrhea since Tuesday, so they made me give them a stool sample. Guess who doesn't have water pouring out her backside anymore? Of course not. Just like I don't have a bleed anymore. :lol:

Bodies are dumb.
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!!

User avatar
CRguy
Posts: 9969
Joined: Sun Feb 10, 2008 6:00 pm

Re: CT shows my liver met is SMALLER!!

Postby CRguy » Mon Jun 24, 2019 12:11 pm

AmyG wrote:Bodies are dumb.

BUTT shrinkage is good .... :shock:
and your attitude kicks BUTT

keep on rockin' sista
keep on rockin'

Cheers and Harmony
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

AmyG
Posts: 244
Joined: Tue Dec 25, 2018 8:08 pm

Re: CT shows my liver met is SMALLER!!

Postby AmyG » Mon Jun 24, 2019 1:09 pm

CEA is down to 24!!!!!!!!

Omfg, this is awesome. Went from 167 when I started chemo, to 98 to 20 freaking 4. Yall, I'm stoked.
42 dx @ 9wks pregnant w/baby #8 8/18
Sigmoid colon resection 9/18
Adenocarcinoma, G2, T3N0M0..or so we thought
KRAS/BRAF wild
Liver biopsy is malignant, stage iv now boys!
Delivered healthy baby 3/19
FOLFOX + Avastin 5/19
CEA 167 to 24 after 4 rounds
Liver resection 8/28/19
NED!!

User avatar
LPL
Posts: 650
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: CT shows my liver met is SMALLER!!

Postby LPL » Mon Jun 24, 2019 2:34 pm

AmyG wrote:CEA is down to 24!!!!!!!!

Omfg, this is awesome. Went from 167 when I started chemo, to 98 to 20 freaking 4. Yall, I'm stoked.

Great News! Hurray :)
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma pt 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a Stage IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung
:!: Steroid induced hyperglycemia dx after 3chemo
Surgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb lung met


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