Has anyone done, or heard of, only 5FU as a second-line treatment?
I would be very interested in learning the rationale behind such a decision. Thanks in advance!
mpbser wrote:Has anyone done, or heard of, only 5FU as a second-line treatment?
mpbser wrote:Has anyone done, or heard of doing, only 5FU (monotherapy) instead of Folifiri/etc after surgery for a liver met recurrence? My signature below may provide a clue.
mpbser wrote:Julie,
Do you happen to know if your CC was tp53 mutated? I read, again as I have seen this expressed a number of times in various journal articles over the past couple years, that "CRC with mutated TP53 is resistant to 5-FU" in this extremely interesting article https://www.ncbi.nlm.nih.gov/pmc/articl ... 3/#cit0021 Even more disturbing, "Overall, 5-FU may induce prosurvival autophagy that partly reverses its apoptosis-inducing effect."
While TP53 is frequently mutated in CRC, the significance of TP53 gene mutations for response of CRC patients to 5-FU-based chemotherapy regimens remains under investigation. TP53 mutation status is not currently used to direct therapy decisions[2], however there is increasing evidence that not all TP53 mutations exert equivalent effects on tumor aggressiveness or chemotherapy response. In particular, there is evidence that TP53 mutations that confer “gain-of-function” by altering the DNA-binding domain of p53 may be particularly deleterious as they cause increased tumor aggressiveness and metastasis in animal models[37,38]
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