mpbser wrote:Has anyone done, or heard of, only 5FU as a second-line treatment?
mpbser wrote:Has anyone done, or heard of doing, only 5FU (monotherapy) instead of Folifiri/etc after surgery for a liver met recurrence? My signature below may provide a clue.
Do you happen to know if your CC was tp53 mutated? I read, again as I have seen this expressed a number of times in various journal articles over the past couple years, that "CRC with mutated TP53 is resistant to 5-FU" in this extremely interesting article https://www.ncbi.nlm.nih.gov/pmc/articl ... 3/#cit0021 Even more disturbing, "Overall, 5-FU may induce prosurvival autophagy that partly reverses its apoptosis-inducing effect."
While TP53 is frequently mutated in CRC, the significance of TP53 gene mutations for response of CRC patients to 5-FU-based chemotherapy regimens remains under investigation. TP53 mutation status is not currently used to direct therapy decisions, however there is increasing evidence that not all TP53 mutations exert equivalent effects on tumor aggressiveness or chemotherapy response. In particular, there is evidence that TP53 mutations that confer “gain-of-function” by altering the DNA-binding domain of p53 may be particularly deleterious as they cause increased tumor aggressiveness and metastasis in animal models[37,38]
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