Seems like everyone has different experiences with this - I did two rounds of FOLFOX without a port, and it was pretty rough. My veins did NOT like it at all, and my arm looked like a roadmap for a couple of months after. I actually think the long 5-FU infusion was tougher than the oxi - it’s just such a long exposure to a mildly corrosive drug. I also think I may have had some mild extravasation on the first cycle. I ended up having the port replaced just to finish the last 2 treatments of neoadjuvant chemo.
Having a port really is no big deal for me; I rarely notice it now.
That said, there’s definitely things you can do to make peripheral more tolerable - be well hydrated, choose a big vein (ideally higher up the arm - we ended up doing bicep), a big cannula, keep the site warm the whole time (heat pack); and as you’ve seen other folk seem to have had no issues.
10/2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1, Dec-20: 2.3, Mar-21=2.5
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection
02/20 Ileo reversed
03/20 NED (CT/PET/MRI/scope) - latest scans Mar ‘21