New Drug info

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natelaugh
Posts: 95
Joined: Wed Apr 03, 2019 11:40 pm

New Drug info

Postby natelaugh » Tue Jun 04, 2019 3:27 am

Hi,

I thought I add a topic on new drug for cancer. Please add other new drug/discovery when it occurs.

UPDATE 1-Amgen drug shows high response rate in small lung and colon cancer trial.

https://news.yahoo.com/1-amgen-drug-shows-high-151127828.html

Amgen drug, which could become the first approved medicine targeting a mutated form of a gene known as KRAS - one of the most common mutations found in non-small cell lung cancer (NSCLC)



Nate.
Caregiver to 80M
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone

User avatar
GrouseMan
Posts: 888
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: New Drug info

Postby GrouseMan » Tue Jun 04, 2019 1:33 pm

We already have a discussion about KRAS G12C going on here:

viewtopic.php?f=1&t=62546

that you might find interesting. AMG510 is a very similar structure small molecule inhibitor of a mutant form of the guanosine triphosphatase (GTPase) KRAS called ARS-1620. Their mechanism of action is probably the same.

regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017


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