Avastin itch and rash

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macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Avastin itch and rash

Postby macpudd » Mon May 20, 2019 9:42 pm

Sorry to bother peoplehere As I am on Avastin for gbm4. I had 6 cycles and am due fr 7th on fri. For over a week i have had a rash and bad itch all over the put me on prednisolone and 2 antihistimnes which i finished yesterday. It helped a bit but itch is back tonight its driving me mad. Its 3am heere, spoke with onc 24hr service there just said go to er. I ve put on calamine but no use and sat in cold shower no use. Anyone got any suggestins of something i could put on my skin to ease it. I try not to scrath but have torn my skin in several places
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine

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ginabeewell
Posts: 272
Joined: Wed Oct 24, 2018 10:30 am

Re: Avastin itch and rash

Postby ginabeewell » Mon May 20, 2019 10:27 pm

When my Vectibix rash was at its worst I would take Benadryl and then use ice packs where it was the worst, namely my face. I’m sorry I know it is TERRIBLE.
45 year old mom of twins (7) and lucky stepmom of 13 and 16 year olds
9/17/18 DX stage 4 CRC w inoperable liver mets (largest 11 cm)
9/20/18 CEA 931
10/1/18 FOLFOX + Vectibix planned 12 rounds
12/12/18 Routine scan showed typhlitis (7 days in hospital) but largest met down to 5 cm. Chemo holiday.
12/26/18 CEA 4.6
1/14/18 Resume chemo (#6-8)
3/27/19 Surgery: HAI pump placement / colon resection
4/8/19 Resume chemo (#9-12) FOLFOX (no OX) + Vectibix
5/20/19 CEA 1.3
7/19/18: 1st of 2 liver resections

macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Re: Avastin itch and rash

Postby macpudd » Mon May 20, 2019 10:38 pm

Thanks Gina, ive taken paracetamol and its not just as painful but the scratching is still there. Will go to gp in morning really dont want to go to er. I just wish it was all over at this stage. Pallitve team are good but i just wish things would finish soon, i can see the upset of my wife and kids
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine

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juliej
Posts: 3017
Joined: Thu Aug 05, 2010 12:59 pm

Re: Avastin itch and rash

Postby juliej » Tue May 21, 2019 6:22 pm

Oral and topical Benadryl should help. Check with your oncologist first to make sure it's okay to take the oral version though.

Another thing you might try is CareVe Itch Relief Lotion. It has an anti-itch ingredient, Pramoxine Hydrochloride, which helps people with eczema who can't stop scratching. Take a warm shower, then follow with the lotion.

Hope this helps!
Juliej
Stage IV, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/11
LAR, liver resec, HAI pump 11/11
Double lung surgery + ileo reversal 2/12
Adjuvant Xeloda 3-9/12
VATS rt. lung 12/21/12 - benign granuloma!
NED 3/17/12 to 6/13/2019, CEA<1

macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Re: Avastin itch and rash

Postby macpudd » Sat May 25, 2019 5:09 am

Thansk for the replys folks, was supposed to have Avastin yesterday but didnot. Blood low again and onc want to try and sort out skin rash, they feel its not from the avastin, so they got a dermatologist to look at it, he thinks it fungal infection and prescribed Daktrin crem and powder and Nizoral shampoo. My wife helped me used it last night and this morn itch not just as bad hope it keeps going that way. Have to see onc in two weeks and have a perfusion mri. Pallitave team are very good, am having urinary accidents andthey brougt round pads for me amd shower chair alos looking to get hospital type bed forme to move to our downstairs bedroom as i can just about go up the stairs now.. thanks again folks.
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine

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GrouseMan
Posts: 812
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Avastin itch and rash

Postby GrouseMan » Tue May 28, 2019 12:17 pm

This is really an uncommon side effect from Avastin. But you may be encouraged from the following.

https://www.ncbi.nlm.nih.gov/pubmed/17075324

This is a case reported in 2006 where a patient had such a rash attributed to Avastin. "This case report, we believe, is the first report of a possible correlation between a rash and a positive drug response associated with bevacizumab, and may initiate further investigation of similar observation."

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Re: Avastin itch and rash

Postby macpudd » Tue May 28, 2019 6:22 pm

Thanks Grousman, am having my annual abdominal ct next wed re the colon cancer I had and then on the fri I have head mri re thr gbm so will know more then. Rash a nd itch not just as bad today bud headaches just the same.
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine

Cured
Posts: 523
Joined: Thu Nov 27, 2008 10:53 pm
Location: MO

Re: Avastin itch and rash

Postby Cured » Tue Jun 04, 2019 2:11 pm

Dear Macpudd, I hope you are doing better. We certainly go through a lot - and the medical Oncs are limited in what they provide.
May God comfort you and give you and your family strength.

I have had 2 doses of Avastin now. My Onc cautioned me about using the nasal spray Affrin, as I got a messy sinus after exposure to spring pollen. I use nature as part of my healing. Sitting outside and getting sun was good. But breathing in cottonwood and other stuff ended up not good.
At night I was laying in bed coughing and needed some relief. After 10 days I am better; but Avastin and such do have multiple impacts.
5-08:Stg 3 Rectal: 6/14 Nodes
Ace Surgeon Remvd 90%Rectum,lots of Colon-Full Incision
Ileo Rev'd 6 Mos.
Radiatn+5fu Pre-Surgery
FOLFOX 8 CyclDone 1-09
Clear Scope 8-17; CEA 2-18
Glory to God! Healed by prayers of many: for 10 years
7-18: tumor pressing against brain Removed
Metastatic to lung. CEA 6.9 Began Folfiri
CEA dropped to 4.5 after 1 chemo
After 8rds CEA 3
CEA 1.8, 2.3,1.7 now
Finished 12 rounds of Folfiri
Avastin every 3 weeks.
Had Seizure Anti-seizure meds working;no driving for 6 months

Claudine
Posts: 64
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Avastin itch and rash

Postby Claudine » Tue Jun 04, 2019 3:12 pm

No itch or rash for my husband but his blood pressure is high now (he's had 6 Avastin treatments so far), I read it's a common side effect unfortunately, he may need blood pressure medication on top of everything :(
Wife of Dx 04/2018 (51 yo). MSS, KRAS mutated G12A
No primary, lytic tumor L4 vertebrae, CEA 10
Radiation 04/2018
Resection small intestine 05/18 (activity on PET scan, but no cancer found)
Xelox * 6, 05/2018 to 10/2018
6.7 cm hypermetabolic left adrenal mass 03/14/2019, 4.4 cm 05/21/2019
SBRT L4 02/2019
Folfiri + Avastin
CEA 58 03/15, 17 03/29, 10 04/12, 6.4 04/26, 5 05/10, 4.8 05/23, 4.2 06/07, 3.6 06/21, 3.2 07/07
Scan 05/21: Multiple small lung nodules shrinking or stable compared to 03/14 scan.

macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Re: Avastin itch and rash

Postby macpudd » Tue Jun 04, 2019 5:51 pm

Anti fungal cream also had steroids in it and wasmessin up my blood sugars so i didnt use it last two days and overnight skin flareing up again so using it again. Got a fright on sunday could not speak properly for over half hour but it did come back. Have had no blood pressure problems. They did give me antihistamine tabs to help with the itch, not sure if that is wat they gaveCured for your nose. Thanks for the replies. I am glad to be having abdominal ct tomorrw my belly is very big and bloated and my arms and legs are very skinny and losing strength.
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine

User avatar
CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Re: Avastin itch and rash

Postby CRguy » Sat Jun 08, 2019 6:38 pm

As a follow up note, some folks here have also had doxycycline (antibiotic) for skin infections while on chemo.

If your docs got you antifungals instead, then maybe ask for one without the steroids ???
or ask if the doxycycline is a different consideration for you ???

In any event, sending you best wishes and hoping things went well with your scans.

In Harmony on the Journey
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Re: Avastin itch and rash

Postby macpudd » Tue Jun 11, 2019 6:24 pm

Thanks CRGUY, antifungal steroid cream seems to be working at last, not as ba with rash and itch. Got Avastin on last fri also had mri and ct last week but have not got results yet. Pallitative care delivered wheelchir and pressure relief cushion yesterday and shower chair. Wheelchair is great as i cant walk very far with having to stop and sit.
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine


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