Peanut related to cancer spread?

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Bostonzj
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Peanut related to cancer spread?

Postby Bostonzj » Tue May 14, 2019 10:41 am

I read a paper a few days ago, saying the peanut consumption might help maretesis of the cancer cells, here is the link https://news.liverpool.ac.uk/2014/12/19 ... er-spread/

I was kind of freak out , I eat peanut butter a few days a week! After read this paper, I stop eating right away! Any body has any thought? My onco never mention that the peanut is prohibited..
female, Dx @ 34 yo,mom to 3 yo daughter
stage 1 colon cancer
surgery on 07/30/2014
CEA <0.5 (after surger), no cea checked pre-op
no chemo needed
pray to god every day!
CT scan :08/2014 clean, 12/2014 clean,11/2015 clean, 11/2016 clean
NED forever!!!!

Pyro
Posts: 303
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Peanut related to cancer spread?

Postby Pyro » Tue May 14, 2019 10:46 am

I think it’s ridiculous, everything in moderation.
Aug 2015- Stage 4 CC with liver Mets(38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not liver surgery candidate
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda fail
Jun 2019 - FOLFURI
Aug 2019 - No more, quality time!

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GrouseMan
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Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Peanut related to cancer spread?

Postby GrouseMan » Wed May 15, 2019 9:47 am

This study is not new it dates from 2014. The Liverpool page cites the following paper.

Here is a link to the original paper: https://www.ncbi.nlm.nih.gov/pubmed/25326505

No follow up that I can see from 2014. While they may still be studying this relationship much more needs to be done in my opinion. This all seems very speculative at this point as far as I am concerned. They are studying tumor cells - Not a clinical trial or even a pre clinical trial in mice where they contrast people or mice given peanuts and those who don't have peanuts. Just because this happens in isolated tumor growth media don't mean it is a significant mechanism in whole animals or people yet.

The interesting thing they say is "TF disaccharide (galactoseβ1,3N-acetylgalactosamineα-) is overexpressed by ~90% of human cancers" This I would think makes this TF disaccharide a very interesting target for immunotherapy to attack cancer cells that over express this on their cell surface. Trouble is this may be expressed in a lot of other cells as well.

If you like peanuts - maybe switch over to other nuts like pecans, walnuts, almonds etc. These tree nuts are probably better for you anyway. I like to eat a lot of nuts, as they are a better snack than chips and other things. Peanuts are however cheaper, and from what I understand in Asia often associated with a type of liver cancer due to a fungus that they can get that produces compounds called aflatoxins. Climate and the fact that a lot of peanuts are consumed in SE Asia the incidence of liver cancer associated with exposure to Aflatoxin is considerably higher than in the US or Europe. The sort of liver cancer associated with Aflatoxins are not very common outside of SE Asia. My father had this sort of liver cancer a couple of years ago, its very rare here. When they discussed this with him he thought it might have been from his time in Korea 60+ years ago.

Here is a link about Peanuts and Aflatoxins: https://www.cancer.gov/about-cancer/cau ... aflatoxins

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

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CRguy
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Joined: Sun Feb 10, 2008 6:00 pm

Re: Peanut related to cancer spread?

Postby CRguy » Mon May 20, 2019 7:42 pm

Thanks for that feedback GrouseMan !

I agree always interesting to find out new info ... BUTT ... not always exact science as reported.

Folks also need to remember that peanuts are not tree nuts,
they are legumes and the aflatoxicosis is almost unknown in N America
due to mandatory preventive measures.

Cheers
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far


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