Pyro70 wrote:You also claim that Japanese trials are far superior to US trials.
I literally said:
rp1954 wrote:There are a lot of things you don't understand about Matsumoto (2002) that make it a lot tighter than most western phase 2 trials.
You're still not reading carefully, your negativity expands and fallaciously generalizes off my very limited statement. One Japanese trial and its paper, Matsumoto (2002), compared to sloppier trials. For example, Matsumoto (2002) had no washouts and dropouts the way many trials do; Matsumoto is tighter on staging, 2-3 vs NZ's 0-4, and better matched treatment to stage and correlated biology. Matsumoto was more careful about nailing down the sialyl Lewis X variable with three CD15s mabs; look how Fig 3C's results for sialyl Lewis X with the FH6 mab would easily help reproduce your NZ trial's less successful results. Nothing magical there.
Pyro70 wrote:You’ve demonstrated a classic example here: you are picking and choosing which trials/data you’ll listen to.
You're projecting. I'm pretty good at finding discrepancies and adjusting better for the differences in the analysis of all data. I'll watch your NZ example carefuly, but you need the full reports and raw data to compare and adjust with further against all the cimetidine trials' data - it is you and your NZ abstract that dodges the details, pretest and post - I don't have your NZ trial's papers and details. One difference is that I pay a lot of attention to factors to make something work, not some goof's quick shake and bake where everybody then died of ptomaine poisoning. In the cases, if NZ has different biology, say due to Western 2010s diet vs Japan 80s diet, or something else like techniques, I'd look for extra data, detail, not just shrug and toss the whole subject out. Or I'd try to find extra oomph to try to make it work in real life, not just sandbag it with a poor imitation or an extra defect.
I don't want to over rely on optimistic data, either. I'm sort of 3rd generation on CRC, ya know, it could be me.
Again, if you can get both reports and datasets for this NZ trial, I'm interested.