Levsin (Hyoscyamine) for LARS

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Badass
Posts: 1166
Joined: Sun Jan 15, 2012 11:42 am

Levsin (Hyoscyamine) for LARS

Postby Badass » Wed Apr 17, 2019 8:17 pm

Has anyone tried this? Interested to hear about experience.

Thanks,
Jane
R.C. 12/23/11 at age 52 T3N0M0
3/1/12 completed Xeloda and radiation
5/4/12 LAR & Ileostomy
6/7/12-10/4/12 6 rounds Xelox
11/27/12 Reversal
7/13/13 1 liver met
8/13 Met resection /hai pump
4/14 Chemo completed (Irinotecan/5fu/fudr in pump)

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CRguy
Posts: 9971
Joined: Sun Feb 10, 2008 6:00 pm

Re: Levsin (Hyoscyamine) for LARS

Postby CRguy » Thu Apr 18, 2019 6:59 pm

bumping up here homie !!!

no personal experience BUTT I seem to recall my B-I-L did have this or a similar med way back.
He went thru a LOTTA stuff with his post-resection / take down issues ...
I am seeing him this Easter weekend so I will try to massage the conversation ... THAT way

Cheers and Harmony
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Badass
Posts: 1166
Joined: Sun Jan 15, 2012 11:42 am

Re: Levsin (Hyoscyamine) for LARS

Postby Badass » Sun Apr 21, 2019 8:59 pm

Thanks, CR Guy!
R.C. 12/23/11 at age 52 T3N0M0
3/1/12 completed Xeloda and radiation
5/4/12 LAR & Ileostomy
6/7/12-10/4/12 6 rounds Xelox
11/27/12 Reversal
7/13/13 1 liver met
8/13 Met resection /hai pump
4/14 Chemo completed (Irinotecan/5fu/fudr in pump)

User avatar
CRguy
Posts: 9971
Joined: Sun Feb 10, 2008 6:00 pm

Re: Levsin (Hyoscyamine) for LARS

Postby CRguy » Mon Apr 22, 2019 12:09 am

Ok so he only recalls taking an "anti-depressant" as I discussed in this prior topic
at the bottom of the page (( SSRI drugs like Celexa / citalopram )) where their side effects work in your favor with LARS !!

viewtopic.php?f=1&t=2888&p=18763

The drug you mention, hyoscyamine, is an anticholinergic = totally different class of drugs.
Antispasmodic and antiulcer action
blocking / decreasing GIT motility
and gastric acid secretions.

Again ... NO personal patient experience ... :(
BUTT webmd has a decent overview of the drug
https://www.webmd.com/drugs/2/drug-1376 ... al/details

basically it wants to SLOW down the GIT issues we get from LARS

bottom line = you need to keep hydrated, read the side EFX lists and get your Docs on board
with ANY issues or questions !!!!!

WORD

Best wishes and Harmony
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Badass
Posts: 1166
Joined: Sun Jan 15, 2012 11:42 am

Re: Levsin (Hyoscyamine) for LARS

Postby Badass » Mon May 20, 2019 7:50 am

Thank you so much for all the research, CRG!
I didn't realize it is an anit-cholinergic, as is immodium-- I wanted off of those, which is why I went the enema route.
So, I guess I will continue with my drug-free, hydro lifestyle!

Sorry for the delayed response. Spring finally arrived in Rochester, NY so I have been on the computer less.
Best to you!

Jane
R.C. 12/23/11 at age 52 T3N0M0
3/1/12 completed Xeloda and radiation
5/4/12 LAR & Ileostomy
6/7/12-10/4/12 6 rounds Xelox
11/27/12 Reversal
7/13/13 1 liver met
8/13 Met resection /hai pump
4/14 Chemo completed (Irinotecan/5fu/fudr in pump)

pete305
Posts: 18
Joined: Mon Nov 23, 2015 8:02 am
Location: ohio

Re: Levsin (Hyoscyamine) for LARS

Postby pete305 » Thu Jun 27, 2019 10:36 am

wife takes hyoscyamine for non-cancer gastro issues. considers it her lifeline drug as it calms the "caffein jitters" that her IBS gives her. Takes as needed and has used it for about 8 years.
male, no history of colon issues, zip, nada, zero,.... a surprise finding!
pathology report said T3 N0 M0, but oncologist said a "deposit" found, so, T3 N1c M0 - Stage IIIb
sigmoid colon surgery 10/21/15, resection
chemo (folfox) 12/28/15 to 4/16, 8 treatmts due to allergic reaction
also treating with lupron for prostate cancer (dx 2005, proton 2006, lupron began 2008)
liver met 9/17, RFA done 10/25/17, no chemo
life is grand - then second liver met 11/18... here we go again

weisssoccermom
Posts: 5956
Joined: Thu May 10, 2007 2:32 pm
Location: Pacific NW

Re: Levsin (Hyoscyamine) for LARS

Postby weisssoccermom » Thu Jun 27, 2019 12:49 pm

I was given Questran for severe diarrhea after gall bladder removal. I've mentioned it to a few people with LAR, their docs have Rx'd it and they've had good results with it. You have to tweak the dosage....too much and you're super constipated. Not enough and it doesn't do the job.

I know one person who took if for LARS but took the whole dose split over the course of the day and it worked miracles for her. Another person used it just once a day. It is one of those drugs you have to experiment with. I haven't personally taken it now in a long time. Back then, it came in a 'crystal' form that you mixed with liquid. Originally, the drug was used to help lower cholesterol but it also has another use....that for severe diarrhea by binding with excess bile salts in the intestines. It is certainly worth a try but you do have to be patient with it. One problem is the dosage is meant for people with high cholesterol (it is a really old cholesterol lowering drug) so, as I mentioned earlier, you have to play around with it. You certainly wouldn't necessarily need the full dose just for diarrhea control.
Dx 6/22/2006 IIA rectal cancer
6 wks rad/Xeloda -finished 9/06
1st attempt transanal excision 11/06
11/17/06 XELOX 1 cycle
5 months Xeloda only Dec '06 - April '07
10+ blood clots, 1 DVT 1/07
transanal excision 4/20/07 path-NO CANCER CELLS!
NED now and forever!
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