During the first cycle of capecitabine development, three concomitant drugs were found to affect 5-FU clearance. Paracetamol and morphine increased 5-FU clearance by 26% and 41%, respectively, and loperamide decreased 5-FU clearance by 31%
Paracetamol is the European version of Tylenol. It works better on me than Tylenol so I brought home several boxes a few months ago. That said, the two are claimed to be identical so the "clearance" issue might apply to Tylenol too. Loperamide, as many of us know all too well, is Imodium. Before I take either one, would someone please translate the quoted sentence for me?