Last shot immunotherapy

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Pyro70
Posts: 155
Joined: Mon Jan 21, 2019 4:25 pm

Last shot immunotherapy

Postby Pyro70 » Fri Apr 12, 2019 6:40 pm

I stumbled upon this NYT article about oncologists trying immunotherapy as a last shot, even if there isn’t any clear evidence (eg biomarker) that it will work in a specific patient. The article is about prostate cancer, but with MSS TMB moderate/high responders, similar arguments can be made for CRC.

Has anyone discussed trying an immunotherapy “Hail Mary” with their oncologist? Do you know of someone that tried it?

https://www.google.com/amp/s/www.nytimes.com/2018/04/26/health/doctors-cancer-immunotherapy.amp.html
Dx Jan 2017 stage IVB w/ PC age 35
FOLFOX
SEP 17 HIPEC 1, anastamosis leak
XELODA
MAR 18 HIPEC 2
JUN 18, ileo reversal and 2nd anastamosis leak

brokenwings
Posts: 101
Joined: Mon Jan 07, 2019 1:50 am

Re: Last shot immunotherapy

Postby brokenwings » Sun Apr 14, 2019 4:33 pm

I can't answer your questions but thanks for the article.
Personally, I don't see any ethical conundrum in giving immunotherapy as a last shot if the patient doesn't have any side effects. I mean, it's not as if you were ruining the last months of his life with chemo...
That's my two cents...
DX 2019 Adenocarcinoma Sigmoid colon. PC + ovarian met.
Obstruction. Temporary colostomy. Primary tumour still there.
Folfirinox: 6 cycles
CT Scan/PET Scan: ok for surgery
Surgery (CRS + HIPEC) 04/29: not optimally resectable, surgery cancelled. Right ovary removed.
2nd ptotocol: IP chemo (oxaliplatin) + IV chemo (Folfiri + Avastin).
07/04: exploratory laparoscopy - necrosis of peri mets
4 more cycles
09/11: CT scan
09/12: last exploratory laparoscopy and final decision

Lee
Posts: 5971
Joined: Sun Apr 16, 2006 4:09 pm

Re: Last shot immunotherapy

Postby Lee » Sun Apr 14, 2019 5:06 pm

Have you red this thread by Jack & Katies mom?

viewtopic.php?f=1&t=60593

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

Lee
Posts: 5971
Joined: Sun Apr 16, 2006 4:09 pm

Re: Last shot immunotherapy

Postby Lee » Sun Apr 14, 2019 5:41 pm

Pyro70 wrote:I

Has anyone discussed trying an immunotherapy “Hail Mary” with their oncologist? Do you know of someone that tried it?

https://www.google.com/amp/s/www.nytimes.com/2018/04/26/health/doctors-cancer-immunotherapy.amp.html


You might want to look up "Beansmama". She was diagnosed with Stage IV colon cancer. Every traditional chemo regiment failed her, she was months away from death. As a last attempt, they put her on Keytruda, and it was successful in shrinking her tumors in her liver to get her to surgery. She had a very major surgery and survived it. The tumor they removed was dead. She passed a few months later, not from cancer butt rather a blood clot. What is important, she died cancer free and she would have been very proud of that fact.

Because of her and people like her, Keytruda, I believe, has been approved by the FDA for colon cancer patients.

There are a few others around here, hopefully they will chime in soon,

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!


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