Disconnect & folfiri questions

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mpbser
Posts: 904
Joined: Wed Apr 19, 2017 11:52 am

Disconnect & folfiri questions

Postby mpbser » Wed Apr 03, 2019 1:33 pm

For those who have done folfiri and/or 5-FU, is it correct that the pump is connected for 48 hours and disconnect can take place after 48 hours have passed since the "start" time of treatment? I need to schedule the local cancer center appointment and don't know if it can be scheduled for 10:30 am on a Wednesday when the "folfiri" treatment has been scheduled for [to start at] 10:30 am on the previous Monday. My husband is indisposed every Wednesday afternoon with a work obligation, so information about disconnect time would be greatly appreciated.

Also, how long does a 5-FU infusion take? Thanks!
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

debsta
Posts: 5
Joined: Sat Mar 30, 2019 11:00 am
Location: Boston MA

Re: Disconnect & folfiri questions

Postby debsta » Wed Apr 03, 2019 3:12 pm

My husband's 5-FU infusion via pump runs 46 hours.

The nurses taught me how to disconnect the pump and then use a saline solution to flush the port. If this option is available to you then it might further save him time.
Caregiver of DH age 68 at DX w/Stage IVb rectal adenocarcinoma - mets in liver and both lungs
MSS MMRp Kras/Braf/Ras all wild-type TMB 3.04 poorly differentiated CEA 14.7
2/2019 Clinical Trial at Dana Farber - mFolfox6, Avastin, Nivolumab

Rikimaroo
Posts: 199
Joined: Tue Dec 20, 2016 8:48 pm

Re: Disconnect & folfiri questions

Postby Rikimaroo » Wed Apr 03, 2019 3:47 pm

Hello Friend,

I had treatment today with Folfiri, the treament started around 10am the actually chemo but I was in the office at 8am. They did blood work, typical premeds, then chemo once all was clear. I have an appointment for Friday at 3pm for disconnect. So yes it is 48 hours typically with pump.

I hope this helps. Good Luck!!
RC T3N1M0
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
Port Scheduled for 12/2017, folfox - avastin 12/2017
Blood Clot in Neck 1/2018, stop avastin, continue FolFox
LAR/Liver Resect 4/2018
Chemo Finish 8/2018
Reversal 10/18
CEA - 12/16 26.1, 1/17 32.2, 3/17 6.6, 11/17 500.5, 12/17 638.5, 1/3/18 424.8, 1/16/18 163.5, 1/31/18 62.2, 2/18 21.1, 3/18 14, 4/18 .8, 10/18 1.2, 12/18 3.2, 2/8 11.4, 3/6 22

Claudine
Posts: 48
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Disconnect & folfiri questions

Postby Claudine » Wed Apr 03, 2019 4:03 pm

We were told 46 hours, but both time my husband let it run a tiny bit more (closer to 48) to make sure the container was totally empty. He disconnects the pump himself, it's not that difficult, once shown and given the proper equipment (latex gloves, sterilizing wipes). This way no need to schedule an appointment to disconnect!
Wife of Dx 04/18 (51 yrs old then). MSS, KRAS mutated G12A
No primary found, lytic tumor L4 vertebrae, CEA 10
Radiation 04/18
Resection small intestine 05/18 (activity on PET scan, but no cancer found)
Xelox * 6, 05/17 to 10/18
6.7 cm hypermetabolic left adrenal mass 03/14, 4.4 cm 05/21
SBRT L4 02/19
Folfiri + Avastin
CEA 58 03/15, 17 03/29, 10 04/12, 6.4 04/26, 5 05/10, 4.8 05/23, 4.2 06/07
Scan 05/21: Multiple small lung nodules shrinking or stable compared to 03/14 scan.

Fluff Bottom
Posts: 73
Joined: Fri Oct 23, 2015 8:13 am

Re: Disconnect & folfiri questions

Postby Fluff Bottom » Wed Apr 03, 2019 5:17 pm

When I leave on chemo day the tell me to come back in about 46 hours. I leave work and head to the infusion center 30 minutes or so after it starts showing “low” on my pump.
10/26/15-Colonoscopy-Mass in Sigmoid Colon
11/17/15 Surgery
Mass is adenocarcinoma with mucinous type components.Lynch Negative
Stage IIIb-T3N1c, 3/13 nodes, High Grade-Poorly Diff to Undiff
12/16/15-Port,began FOLFOX
CEA .8 before surgery
Finished 12 rounds of FOLFOX 5/22/16
5/22/18-Clear CT
9/6/18-CT for possible hernia shows mets
9/18/18 PET confirms mets to lungs, liver peritoneum
10/23/18-Chest CT shows rapid growth of mets

zephyr
Posts: 222
Joined: Thu Aug 18, 2016 7:31 am

Re: Disconnect & folfiri questions

Postby zephyr » Wed Apr 03, 2019 6:21 pm

46 hours here too - from the time the PUMP was connected.
Nov-2009 Early stage CRC found during routine colonoscopy
2010, 2011, 2014 Follow up colonoscopies, all clear
Jun-2016 CRC found during routine follow up colonoscopy, surgery, Stage 4, KRAS, MSS, inoperable lung mets
Aug-2016-May-2018 Folfox, 5FU & Avastin, 5FU, Folfiri & Cyramza
Aug/Sep-2018 YAG laser surgeries (Germany) on both lungs, 11 nodules (9 mets) removed
Nov-2018 clean CT scan
Mar-2019 New lung nodules
April-2019 Xeloda + Avastin

Punky44
Posts: 293
Joined: Mon Oct 01, 2018 4:29 pm

Re: Disconnect & folfiri questions

Postby Punky44 » Wed Apr 03, 2019 7:05 pm

My mom’s is exactly 46 hours as well. They did tell us that it is ok to leave it for a little while after it shuts off if we couldn’t make it in time but we never ran into that issue.
Caregiver to my amazing mom (68)
10/1/18 DX with rectal cancer; CEA 17 at diagnosis
MRI/CT/PET puts staging at T3N2M0
Total neoadjuvant therapy:
8 rounds Folfox 11/5/18 - 2/11/19
Short course radiation 3/14/19 - 3/20/19
Robotically assisted laparoscopic LAR 3/21/19
Pathology report says yT2N0M0 with 0/38 nodes
CEA 4/23: 2.1

Me: 34, first colonoscopy 11/16/18—normal! Come back in 5 years.

Gravelyguy
Posts: 163
Joined: Thu Jul 05, 2018 6:03 pm

Re: Disconnect & folfiri questions

Postby Gravelyguy » Wed Apr 03, 2019 9:21 pm

46 hours for me on FolFox. I was never given the option to disconnect myself but they did show me how to turn it off. That way I could turn it off and finish teaching then go to the infusion center and get disconnected when I had time.

It worked pretty slick. It was a pretty good teachable moment for the kids too.

Dave
6/17 dx mCRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0

Gravelyguy
Posts: 163
Joined: Thu Jul 05, 2018 6:03 pm

Re: Disconnect & folfiri questions

Postby Gravelyguy » Wed Apr 03, 2019 9:22 pm

Also it was 46 from starting the pump. The infusions for FolFox took about 4 hours for me not sure about your husbands chemo.

Dave
6/17 dx mCRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0

Pyro
Posts: 237
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Disconnect & folfiri questions

Postby Pyro » Thu Apr 04, 2019 8:59 am

I usually got out of the ONC office after doing FOLFIRI about 2, which made my disconnect about 1200, 46 hours later.
Aug 2015- Diag Stage 4 CC with mets to liver (38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not a surgery candidate for liver
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery, Dr. Vauthey
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda, CEA @36, treatment failure

Pyro70
Posts: 99
Joined: Mon Jan 21, 2019 4:25 pm

Re: Disconnect & folfiri questions

Postby Pyro70 » Thu Apr 04, 2019 9:06 am

Definitely should just disconnect yourself. When I was getting TPN my girlfriend was even accessing my port so I could swim during the day- it’s not so difficult.
Dx Jan 2017 stage IVB w/ PC age 35
FOLFOX
SEP 17 HIPEC 1, anastamosis leak
XELODA
MAR 18 HIPEC 2
JUN 18, ileo reversal and 2nd anastamosis leak

Pyro
Posts: 237
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Disconnect & folfiri questions

Postby Pyro » Thu Apr 04, 2019 9:57 pm

What the....
Aug 2015- Diag Stage 4 CC with mets to liver (38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not a surgery candidate for liver
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery, Dr. Vauthey
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda, CEA @36, treatment failure


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