oncolytic virus trials

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Tim UK
Posts: 74
Joined: Fri Jun 12, 2015 1:05 am

oncolytic virus trials

Postby Tim UK » Mon Apr 01, 2019 3:31 pm

Hello all

It's been a while since I posted. Sorry. Been ducking and diving with a few trials (anti-GITR then ERK inhibitor). Most enduring was the Roche CEA/TCB phase 1 trial in Barcelona that kept me going for about 18 months. Eventually all these ran out of efficacy so I'm back on the folfoxiri + avastin regime, done 9 out of 12 rounds. Yuk. Weight dropped from 75 to 55 kgs, so I'm trying to reverse that too. My CEA hit 450 and CA19-9 hit 60,000 (!). Down to 100 and 5,000 respectively now.

My question: has anyone come across effective oncolytic virus treatments in the US or Europe? I'd be really grateful for any leads.

Best wishes
Tim
https://youtu.be/qoQbY4A5RNA
05/15 L hemi-colectomy
05/15 Dx st 3 T4N2M0 @43
kids: now 13, 10
BRAFm mucinous - KRASw
06/15 liver mets
06/15 CEA 9, CA19-9 400+
06/15 - 09/15 6 x FOLFOXIRI+Avastin
09/15 markers 4/50
10/15 drain-site met
11/15 CRS+HIPEC
1-8/16 BRAF triplet (dabrafenib, panitumumab, trametinib)
CEA;CA19-9: range 16;650 to 1;36 back to 4;135
8/16 progression
10/16 Trial: NCT02650713
Trials: anti-GITR then ERK inhibitor
6/18 progression, back to chemo
Current: 12 rounds of folfoxiri + avastin

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Jack&KatiesMommy
Posts: 585
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: oncolytic virus trials

Postby Jack&KatiesMommy » Mon Apr 01, 2019 3:38 pm

Tim:
Are you MSI or MSS? Do you know your mutation burden? Keytruda has been working for me after 7 years of fighting my cancer back. I am MSS but have a moderate mutation burden so it is working for me. It may be an option for you.
Cynthia
Mommy to Jack (8) now (16) and Katie (4) now (12)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection
8/13-12/15 (10) RFAs lungs
5/17: Upper Left Lobe of lung resected.
02/18: 3 new mets lymph nodes lung:
05/18: Keytruda (MSS w/Intermediate TMB): CEA: 66.4, 39.2, 23.8, 13, 3.5 1.8, 1.0, 2.8 3.9, 5.0, 5.6, 1.5, .8, .8, 1.1, 1.1, .7
7/18; 9/18; 11/18; 2/19 Clear CT scans

User avatar
CRguy
Posts: 9900
Joined: Sun Feb 10, 2008 6:00 pm

Re: oncolytic virus trials

Postby CRguy » Mon Apr 01, 2019 5:05 pm

Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far


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