hopie wrote: Another possibility might be to look at trends in your bloodwork if you have the data. If you can pinpoint an approximate time for when you have developed resistance, some markers might pop up?
betsydoglover wrote:How far apart are your scans? Mine were 2 mo apart when first treated for Stage 4, then 3 and then 4. Long time until I went to 6. If your scans are frequent enough, then you don't really need another test.
boxhill wrote:Hi Zephyr,
Your sig doesn't say anything about your tumor genetics. Are you MSS or MSI? I rechecked and saw that you are KRAS mutated. sorry.
I don't have anything to offer about testing between scans, although I do sympathize: CEA isn't a marker for me, either, so the question of whether FOLFOX was or was not working was always a mystery. CA 19-9 is primarily a marker for pancreatic cancer, although according to my onc there is some overlap. But he said it can be difficult to get the insurance companies to pay for it.
What I'm wondering about is whether you have any treatment options other than Xeloda, which to my layperson's eyes appears unlikely to work if 5FU didn't, since it is essentially the same thing. That would depend mostly on your tumor genetics. KRAS lets out the anti-EFGR drugs like Erbitux, but what about immunotherapy?.
Zephyr wrote:
I believe the combination of MSI and KRAS exclude immunotherapy options but I'm checking into the Foundation One information.
LPL wrote:Zephyr wrote:
I believe the combination of MSI and KRAS exclude immunotherapy options but I'm checking into the Foundation One information.
Where have you heard that? I thought it was the MSI status and not the mutations that was of importance.. Please share when you find out.
zephyr wrote:LPL wrote:Zephyr wrote:
I believe the combination of MSI and KRAS exclude immunotherapy options but I'm checking into the Foundation One information.
Where have you heard that? I thought it was the MSI status and not the mutations that was of importance.. Please share when you find out.
Is there an emoticon here to show knocking one's head against a wall? I'm MSS not MSI. Sheesh. Too many acronyms and too much data in my head today. That said, I will absolutely share whatever I learn.
zephyr wrote:
Thanks, hopie, that's a good idea. I have all my labs for the past several years. By tracking the numbers, maybe on a spreadsheet, I will be able to pick up less obvious markers.
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