Page 1 of 1

Life Extension article: Chemotherapy (101 and beyond)

Posted: Fri Mar 29, 2019 11:27 am
by zephyr
I was having an online chat this morning with a representative of LifeExtension - looking for their CRC protocols to see how closely they matched what I'm already doing or taking. I was sent this link to an article on chemotherapy and thought others might be interested in reading it.

You can easily access the sections by selecting from the dropdown list. Those sections are:
Table of Contents
How Does Chemotherapy Work?
How is Chemotherapy Administered?
Chemotherapy Dose Optimization
Novel and Emerging Concepts In Chemotherapy
Lessening Chemotherapy Side Effects
The Controversy: Antioxidant Supplementation and Chemotherapy
Integrative Strategies to Complement Chemotherapy

Re: Life Extension article: Chemotherapy (101 and beyond)

Posted: Fri Mar 29, 2019 1:57 pm
by rp1954
Well, that summary list is a good find, a key piece to LEF's rejiggered cancer series. I see LEF started this new monograph ca 2016. It has mutated doses and supplements some, perhaps somewhat more generalized for cancers rather than just CRC. Some things are moved to more of a support category, on their accepted evidence levels, so far. Perhaps its an update of the older CRC specific lists, which I think are still worth reviewing for candidate pills and doses.

Celecoxib which is considered more CRC specific has been re-replaced by Lodine, an older generic COX2 inhibitor in the general cancer tx scheme. I do note that we used some of these items and other natural additions, at sharply higher doses. e.g. vitamin B6, B12, coQ10, C and D3.

What is also important is that they have added a brief page on chemotherapies. Lo and behold, there is the base or root immunochemo formula for my wife:
UFT + PSK +- (targeted) cimetidine ! Please note the that the Futraful information entry is tegafur only, where UFT (tegafur + uracil) should be considered generally superior for CRC, nicer and more effective with smaller pills. The only reason I'd buy tegafur alone, would be to hand load the uracil ourselves, where some countries may only have tegafur available.

Re: Life Extension article: Chemotherapy (101 and beyond)

Posted: Sat Mar 30, 2019 8:45 am
by mpbser
Thanks for sharing! I found this to be very interesting: Cancer cells have highly developed mechanisms to rid themselves of toxins and degrade cytotoxic agents, including chemotherapy drugs. One key mechanism by which cancer cells eliminate toxins depends upon a protein called P-glycoprotein. This cell-membrane protein, which occurs in high amounts on cancer cells, pumps chemotherapeutic agents out of cancer cells. It is one of the chief culprits in multi-drug resistant cancer. Several natural compounds, such as quercetin, epigallocatechin-3-gallate (EGCG) from green tea, genistein, and curcumin inhibit P-glycoprotein (Abdallah 2015; Bansal 2009; Boumendjel 2011).

My husband was taking three out of four of those (+ others) when his liver tumor shrank from 1.3 x .9 cm to 1.1 x .4 cm.

Very, very, very helpful information ... py/Page-06