Life Extension article: Chemotherapy (101 and beyond)

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Joined: Thu Aug 18, 2016 7:31 am

Life Extension article: Chemotherapy (101 and beyond)

Postby zephyr » Fri Mar 29, 2019 11:27 am

I was having an online chat this morning with a representative of LifeExtension - looking for their CRC protocols to see how closely they matched what I'm already doing or taking. I was sent this link to an article on chemotherapy and thought others might be interested in reading it.

You can easily access the sections by selecting from the dropdown list. Those sections are:
Table of Contents
How Does Chemotherapy Work?
How is Chemotherapy Administered?
Chemotherapy Dose Optimization
Novel and Emerging Concepts In Chemotherapy
Lessening Chemotherapy Side Effects
The Controversy: Antioxidant Supplementation and Chemotherapy
Integrative Strategies to Complement Chemotherapy
Nov-2009 Early stage CRC found during routine colonoscopy
2010, 2011, 2014 Follow up colonoscopies, all clear
Jun-2016 CRC found during routine follow up colonoscopy, surgery, Stage 4, KRAS, MSS, inoperable lung mets
Aug-2016-May-2018 Folfox, 5FU & Avastin, 5FU, Folfiri & Cyramza
Aug/Sep-2018 YAG laser surgeries (Germany) on both lungs, 11 nodules (9 mets) removed
Nov-2018 clean CT scan
Mar-2019 New lung nodules
April-2019 Xeloda + Avastin

Posts: 1518
Joined: Mon Jun 13, 2011 1:13 am

Re: Life Extension article: Chemotherapy (101 and beyond)

Postby rp1954 » Fri Mar 29, 2019 1:57 pm

Well, that summary list is a good find, a key piece to LEF's rejiggered cancer series. I see LEF started this new monograph ca 2016. It has mutated doses and supplements some, perhaps somewhat more generalized for cancers rather than just CRC. Some things are moved to more of a support category, on their accepted evidence levels, so far. Perhaps its an update of the older CRC specific lists, which I think are still worth reviewing for candidate pills and doses.

Celecoxib which is considered more CRC specific has been re-replaced by Lodine, an older generic COX2 inhibitor in the general cancer tx scheme. I do note that we used some of these items and other natural additions, at sharply higher doses. e.g. vitamin B6, B12, coQ10, C and D3.

What is also important is that they have added a brief page on chemotherapies. Lo and behold, there is the base or root immunochemo formula for my wife:
UFT + PSK +- (targeted) cimetidine ! Please note the that the Futraful information entry is tegafur only, where UFT (tegafur + uracil) should be considered generally superior for CRC, nicer and more effective with smaller pills. The only reason I'd buy tegafur alone, would be to hand load the uracil ourselves, where some countries may only have tegafur available.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

Posts: 904
Joined: Wed Apr 19, 2017 11:52 am

Re: Life Extension article: Chemotherapy (101 and beyond)

Postby mpbser » Sat Mar 30, 2019 8:45 am

Thanks for sharing! I found this to be very interesting: Cancer cells have highly developed mechanisms to rid themselves of toxins and degrade cytotoxic agents, including chemotherapy drugs. One key mechanism by which cancer cells eliminate toxins depends upon a protein called P-glycoprotein. This cell-membrane protein, which occurs in high amounts on cancer cells, pumps chemotherapeutic agents out of cancer cells. It is one of the chief culprits in multi-drug resistant cancer. Several natural compounds, such as quercetin, epigallocatechin-3-gallate (EGCG) from green tea, genistein, and curcumin inhibit P-glycoprotein (Abdallah 2015; Bansal 2009; Boumendjel 2011).

My husband was taking three out of four of those (+ others) when his liver tumor shrank from 1.3 x .9 cm to 1.1 x .4 cm.

Very, very, very helpful information ... py/Page-06
Wife 4/17 Dx age 45
5/17 LAR
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

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