How long did folfiri work

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Trying
Posts: 250
Joined: Sun May 13, 2018 10:11 pm

How long did folfiri work

Postby Trying » Fri Mar 08, 2019 5:06 pm

In due for another scan in a couple weeks. Just curious how long you were on folfori for before changing things up. Now im freaking out a bit of my test which is 3 days before disneyland!
Last edited by Trying on Fri Mar 08, 2019 5:18 pm, edited 2 times in total.
38 yr old single mom of almost 2 year old at the time
April 2018 colon cancer stage IV 10 liver mets and peri met. Folfox and 12 rounds oxyplatin
Fec 2018 Down to 2 mets in liver. 8 dissapeared
July 2019 switched to xeloda pills as I prefer to 3 day infusion. Also on avistan
Oct 2019 emergency colostomy due to perforated bowel. ( unreal pain)
Feb 2020 show 2mm tumor increase.
Plan to go back on oxy
Oxy failed- irinotecan as of of Sept 2020

RichieTheK
Posts: 13
Joined: Mon May 29, 2017 11:27 am

Re: How long did folfiri work

Postby RichieTheK » Fri Mar 08, 2019 5:11 pm

I went through 46 cycles of FOLFIRI before my cancer adapted to it, so about 22 months.This was with a higher than normal dose of Irinotecan.

Rich
DX 5/13/2016 (Friday the 13th) mRCa Stage 4b
Met Liver, Lungs, Spine
mut KRAS G12V
mut PIK3CA
MSS
5/15/2016 Tumor partially obstructive; colostomy performed
5/2016 FOLFIRI with higher dose of Irinotecan
8/2017 Signs of tumor growth, added Avastin to FOLFIRI
4/16/2018 Primary tumor invading surrounding tissue. Chemo stopped
5/2018 Started radiation.
6/2018 Radiation finished
7/2018 Start FOLFOX
1/2019 FOLFOX canceled due to neuropathy after 14 cycles.
Maintenance, 5FU and Avastin
6/2019 FOLFIRI

Trying
Posts: 250
Joined: Sun May 13, 2018 10:11 pm

Re: How long did folfiri work

Postby Trying » Fri Mar 08, 2019 5:19 pm

Thanks for the quick reply
38 yr old single mom of almost 2 year old at the time
April 2018 colon cancer stage IV 10 liver mets and peri met. Folfox and 12 rounds oxyplatin
Fec 2018 Down to 2 mets in liver. 8 dissapeared
July 2019 switched to xeloda pills as I prefer to 3 day infusion. Also on avistan
Oct 2019 emergency colostomy due to perforated bowel. ( unreal pain)
Feb 2020 show 2mm tumor increase.
Plan to go back on oxy
Oxy failed- irinotecan as of of Sept 2020

kandj
Posts: 314
Joined: Sun Sep 27, 2015 11:29 am

Re: How long did folfiri work

Postby kandj » Sat Mar 09, 2019 1:48 am

My husband had 50+rounds of either folfox/folfiri/plain 5fu/lecuovorin (pretty sure I spelled that wrong). He only switched to Xeloda because hes dealing with a lung met and they respond better to that I guess. All the changes in the above were not because he didn't respond or the cancer got smarter, but rather because of surgeries and treatments and the doctors preferred followup chemos. He did have to stop after 11 oxaliplatin doses. That was due to neuropathy.

looks like your tumors have had a good response to the Folfiri. That is great!
wife to DH, dx 8/15 stage IV @36, 12+ liver Mets
HAI placed 12/15
Liver resect 5/19/2016 15-20 mets (surgeon lost count)
Liver Recurrence 7/2017-radiation
Lung met 10/18 VATS
lung/adrenal gland recurrence 11/19
Adrenal ablation 2/20 VATS 3/20
Radiation: 9/20 adrenal gland, 2/21 pancreatic node
9/2021 liver, 4/22 esophageal node
7/2023 proton therapy: liver
140+ rounds of chemo and counting
Chest nodes, lung nodules, and esophageal nodes currently.

Pyro
Posts: 305
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: How long did folfiri work

Postby Pyro » Sat Mar 09, 2019 8:48 am

I’ve had 60+ treatments on it and it was still going strong. Switched to Keytruda to try it and take a break.
Aug 2015- Stage 4 CC with liver Mets(38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not liver surgery candidate
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda fail
Jun 2019 - FOLFURI
Aug 2019 - No more, quality time!

Trying
Posts: 250
Joined: Sun May 13, 2018 10:11 pm

Re: How long did folfiri work

Postby Trying » Sun Mar 10, 2019 7:32 pm

Thank you all. Hope i get a few more responses too!
38 yr old single mom of almost 2 year old at the time
April 2018 colon cancer stage IV 10 liver mets and peri met. Folfox and 12 rounds oxyplatin
Fec 2018 Down to 2 mets in liver. 8 dissapeared
July 2019 switched to xeloda pills as I prefer to 3 day infusion. Also on avistan
Oct 2019 emergency colostomy due to perforated bowel. ( unreal pain)
Feb 2020 show 2mm tumor increase.
Plan to go back on oxy
Oxy failed- irinotecan as of of Sept 2020


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