CA 19-9

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Fluff Bottom
Posts: 77
Joined: Fri Oct 23, 2015 8:13 am

CA 19-9

Postby Fluff Bottom » Wed Feb 20, 2019 3:36 pm

Happy Wednesday everyone! My CA 19-9 is tested monthly. It was originally 180, then 60 after a few rounds of chemo. Now it’s jumped to 92(over 35 is high). I have my scans on March 4th and will find out if things are stable or growing.

In the meantime I was just wondering if you watch CA 19-9 for a trend like CEA (mine has never been over 3) before you worry? I’m wondering if my current FOLFIRI regime might not be working any longer.

Just seeing if anyone had a similar experience. Thanks!
10/26/15-Colonoscopy-Mass in Sigmoid
adenocarcinoma mucinous type components.
Lynch Neg
Stage IIIb-T3N1c, 3/13 nodes, High Grade-Poorly Diff to Undiff
12/16/15-Port, FOLFOX
12 rounds FOLFOX 5/22/16
5/22/18-Clear CT
9/6/18-CT for possible hernia=mets
9/18/18 PET mets to lungs, liver, peri
10/23/18-rapid growth of mets
BRAF V600, KRAS Wild, MSS
Back on FOLFOX=reaction
FOLFIRI until it failed
Tafinlar/Mekinist=Kidney Failure
Mets to uterus, adrenal gland
Low dose Stivarga/Opdivo. Possible liver toxicity.

rp1954
Posts: 1855
Joined: Mon Jun 13, 2011 1:13 am

Re: CA 19-9

Postby rp1954 » Wed Feb 20, 2019 5:46 pm

CA199 is subject to greater rises during chemo because of the cumulative chemo damage. I don't have personal Folfiri insights. What is your MCV series doing compared to last time on Folfox ? (MCV CEA CA199 time series?) The blood data on Folfiri is subject to a lot more cumulative noise and your oncologist may focus on basics like RBC-WBC-platelets and wait for the scan once the CA199 and CEA go wild on chemo.

I would have waited longer for others to answer but I'm leaving in a few minutes.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements

Fluff Bottom
Posts: 77
Joined: Fri Oct 23, 2015 8:13 am

Re: CA 19-9

Postby Fluff Bottom » Sun Feb 24, 2019 6:11 pm

RP1954, thank you so much for your reply. Your unbelievable knowledge and the fact that you take the time to share it with this board is appreciated more than you will ever know. Your wife is so lucky to have you in her corner!

I’m trying to get my act together and look at my blood work like you mentioned.

Thanks again!
10/26/15-Colonoscopy-Mass in Sigmoid
adenocarcinoma mucinous type components.
Lynch Neg
Stage IIIb-T3N1c, 3/13 nodes, High Grade-Poorly Diff to Undiff
12/16/15-Port, FOLFOX
12 rounds FOLFOX 5/22/16
5/22/18-Clear CT
9/6/18-CT for possible hernia=mets
9/18/18 PET mets to lungs, liver, peri
10/23/18-rapid growth of mets
BRAF V600, KRAS Wild, MSS
Back on FOLFOX=reaction
FOLFIRI until it failed
Tafinlar/Mekinist=Kidney Failure
Mets to uterus, adrenal gland
Low dose Stivarga/Opdivo. Possible liver toxicity.


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