Postby rp1954 » Sun Feb 17, 2019 1:10 pm
We seem to have had unusually good experience for peri+liver mets but I don't think it was rare happenstance.
Round 1. Our experience with destruction of the peri mets was first - earliest, by mild chemistry cocktail and immune processes alone, before surgery, before chemo. One of the things that I didn't know then was that the peritoneum was a precursor rich environment, in addition to the blood high levels of neutrophils (granulocytes) typical at diagnosis or recurrence. Between chemically altering the cancer cell life cycles and/or simply switching the granulocytes' and their cytocidal abilities, "ON", the extra chemistry was very destructive to my wife's peri mets in 1-3 weeks. My wife represents common fairly bad markers but no one else reports with the timely combination of markers and chemistry.
Round 2. We got a second surgery (inoperable then, for PALN) because we plausibly showed that we had stopped metastasis. What we did different was keep up the extra immune and mild chemo attack daily, with no gaps.
Round 3. We dramatically shrank (unbiopsied) liver masses while on immunochemo, after turning up the immune components in the immunochemo (and after a surgical reduction of PALN met load elsewhere).
Some fundamental, underlying issues to surgery on the peri + liver met, that the surgeons are missing (in my opinion), is how to bridge the perioperative chemo gap, and reduce immune suppression from surgery itself. I've discussed "how to" on the chemo gap before. Our address of the immune suppression from surgery was a more aggressive version of Life Extension's first aid formula from 2010.
Between you and my wife, differences might be matching marker phenotype features, post chemo altered cancer cells and cytokines, with lower immune function and fewer WBC available. Our initial time and money commitments were low, and they can be done while everything else is in chaos or suspense, waiting for a call or interview.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements