Bad News

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Pyro
Posts: 305
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Bad News

Postby Pyro » Mon Feb 18, 2019 8:43 pm

Stewsbetty wrote:
dliu wrote:I think her KRAS mutation might rule out Keytruda for us, but I'll ask. Thank you.


Kras doesn’t rule out Keytruda, however it is usually not recommended for MSS. There is a thread on here that tells of a MSS patient getting Keytruda due to her high tumour mutuational burden. If you check your mom’s tumour testing and see a high number of mutations, it might be something worth looking into.

I have Kras mutation and am MSI h. I have been on Keytruda for 18 months now and have had an amazing response.

Hope the news from your scan isn’t too devastating.
Beth


Admission time! I’ve been doing this over 3 years, I start Keytruda in 2 weeks and I know I’m KRAS and I have a high enough mutation burden to get Keytruda but.............I have know idea if I’m MSS or MSI. I can’t read the reports from MD Anderson, guess I’ll ask soon. :shock:
Aug 2015- Stage 4 CC with liver Mets(38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not liver surgery candidate
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda fail
Jun 2019 - FOLFURI
Aug 2019 - No more, quality time!

Stewsbetty
Posts: 170
Joined: Thu Jul 14, 2016 7:08 am

Re: Bad News

Postby Stewsbetty » Wed Feb 20, 2019 7:26 am

Pyro wrote:
Stewsbetty wrote:
dliu wrote:I think her KRAS mutation might rule out Keytruda for us, but I'll ask. Thank you.


Kras doesn’t rule out Keytruda, however it is usually not recommended for MSS. There is a thread on here that tells of a MSS patient getting Keytruda due to her high tumour mutuational burden. If you check your mom’s tumour testing and see a high number of mutations, it might be something worth looking into.

I have Kras mutation and am MSI h. I have been on Keytruda for 18 months now and have had an amazing response.

Hope the news from your scan isn’t too devastating.
Beth


Admission time! I’ve been doing this over 3 years, I start Keytruda in 2 weeks and I know I’m KRAS and I have a high enough mutation burden to get Keytruda but.............I have know idea if I’m MSS or MSI. I can’t read the reports from MD Anderson, guess I’ll ask soon. :shock:


I am excited for you! It has made such a huge difference in my life. I hope that it is equally effective for you.
42yo At diagnosis. Female in BC, Canada
Dx: CC ascending
Right Hemi colectomy 06/16 clear margins
Adenocarcinoma 6cm High Grade
pT3 pN2a Stage 3
10 out of 16 lymph involved
MSI-h, Kras mut, Braf wild
Finished chemo Feb. 2017
PET scan showing active area April 2017
July 2017 CT showing LN mass and spread to other LN
Stage 4
Aug 2017 failed Fofiri
Sept 2017 keytruda scans every 3 months showing shrinkage and stability
November 2018 CT shows only 1 small tumour left
September 2019 clear CT finally NED!!!

Pyro
Posts: 305
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Bad News

Postby Pyro » Wed Feb 20, 2019 8:00 am

Thanks! I’m worried about the side effects, it could be anything. I hate FOLFURI, but I know what to expect.
Aug 2015- Stage 4 CC with liver Mets(38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not liver surgery candidate
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda fail
Jun 2019 - FOLFURI
Aug 2019 - No more, quality time!

boxhill
Posts: 789
Joined: Fri Apr 06, 2018 11:40 am

Re: Bad News

Postby boxhill » Sat Mar 02, 2019 7:30 am

Pyro, I'm having my 4th infusion of Keytruda on Monday the 4th of March, and so far haven't had any side effects at all that I can identify. (Knocking on wood :D )

Totally unlike the hammer of fatigue crashing down after disconnect day with Folfox. Not to mention the cold sensitivity of Oxy, or the ongoing neuropathy I developed at the very end, despite cutting and then eliminating it. And the low platelets and neutrophils. And I was a lucky one who didn't have nausea at all!

After the first infusion of keytruda I was disoriented, just waiting for that hammer. I realize that if one does develop a problem with keytruda it can be nasty. But so far, so good. Keeping all appendages crossed for both of us. :D

dliu, is the HAI pump a possibility for your mother? Don't know where you are located, but Dr. Kemeny at MSK is the leading authority on the pump, although it is available elsewhere.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/20 MRI stable/NED
6/20 Stop Key
All MRIs NED


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