Has anyone had experience with Irox as a treatment alternative to Folfox? I am unfortunately one of the few people who experience true cardiotoxicity that doesn't even respond to pre treatment with cardiac meds. So, I was informed they'd be removing the 5FU and adding irinotecan starting with my next infusion. I've googled and see that its effective but the side effect profile sounds quite harsh, including severe diarrhea, nausea and hair loss. Aside from the cardiac events, my side effects on Folfox were manageable, so now I'm anxious. Does anyone here have experience with side effects on this combo? I know there are older threads on this but was curious about more recent experiences.