Genetic link

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JBell550
Posts: 20
Joined: Sun Feb 03, 2019 3:57 am

Genetic link

Postby JBell550 » Mon Feb 04, 2019 8:37 am

Hi again,
Yet another question (sorry). Is it still possible to get colon cancer even if No one else in your family has ever had it?
Thanks
J x

mpbser
Posts: 912
Joined: Wed Apr 19, 2017 11:52 am

Re: Genetic link

Postby mpbser » Mon Feb 04, 2019 3:03 pm

Absolutely. My husband has colon cancer but he does not have any inherited genetic mutations. His genomic testing report says, "There could be a mutation in your family, causing cancers in other family members, but you did not inherit it."
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

mandosquiddy
Posts: 32
Joined: Sat Oct 06, 2018 11:45 am
Location: Colorado
Contact:

Re: Genetic link

Postby mandosquiddy » Mon Feb 04, 2019 3:11 pm

I also had genetic testing that showed nothing and there are no others in my family that have had it (at least in recent history).
4/2017 DX: sigmoid colon cancer
colectomy/colostomy
stage II with one positive margin
5/2017 - 11/17 12 rounds of FOLFOX
11/17 - 12/17 Increase in back pain and testicular pain.
CEA increased, CT scan indicated mass on rectal portion of colon
1/18 - 2/18 25 rounds of radiation treatment
5/18 surgery, interoperative radiation, bladder/ureter modification
7/18 normal blood work and CT scan
9/18 increased CEA, mass on outside of small intestine
10/18 Debulking surgery/illeostomy
1/19 Ostomy reversal

Lee
Posts: 5939
Joined: Sun Apr 16, 2006 4:09 pm

Re: Genetic link

Postby Lee » Mon Feb 04, 2019 3:14 pm

Me too. No family history of colon cancer that we have found.

Someone here who had been diagnosed asked her surgeon, why me. He responded, half is genetic, half is just dumb luck.

When do you get your pathology report?

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

JBell550
Posts: 20
Joined: Sun Feb 03, 2019 3:57 am

Re: Genetic link

Postby JBell550 » Tue Feb 05, 2019 3:22 am

Some time towards the end of this week.

erins
Posts: 43
Joined: Sun May 27, 2018 12:41 pm

Re: Genetic link

Postby erins » Thu Feb 07, 2019 5:33 pm

JBell550 wrote:Hi again,
Yet another question (sorry). Is it still possible to get colon cancer even if No one else in your family has ever had it?
Thanks
J x


Just want to add—you can use your abnormal colonoscopy as an excuse to push your family members to get scoped as well. We don’t know all genetic or environmental factors that lead to CRC, but with the rise in young onset CRC, having a reason to get a screening can be a literal lifesaver.
38 yr old female
Rectal bleeding for 1 month—>
5/4/18 colonoscopy found mass in sigmoid colon
5/21/18 LAR
stage 2a, 0/17 lymph, clean margins
T3N0M0 G1
LVI neg, PNI neg, MSS
9/21/18 CEA 0.8
11/16/18 CEA 0.8 & CT clear
12/7/18 iron infusion
2/1/18 iron improved, CEA stable.


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