5FU ineffective against tp53 mutation

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mpbser
Posts: 912
Joined: Wed Apr 19, 2017 11:52 am

5FU ineffective against tp53 mutation

Postby mpbser » Thu Jan 31, 2019 10:12 am

For a long time, I have been interested in comments I have seen on this forum about the ineffectiveness of standard chemo against the tp53 mutation. I had been under the impression that that applied to those with inherited tp53 mutation but I never did enough reading to firmly conclude that this was accurate. My husband has no known inherited mutations but his primary tumor definitely had tp53 among a couple others. So, this lead me to wondering if, since 5FU is ineffective against the tp53 mutation (https://www.sciencedaily.com/releases/2 ... 082124.htm), it was the Ox- that he responded so well to and not the Xeloda/5FU when he did XELOX.

rp1954, since your wife only did Xeloda and no Ox-, I am wondering what her genomic testing results were. Does she have any inherited mutations? Was tp53 mutation present in her tumor?
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

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