Stewsbetty wrote:... If you are MSI I think drs very willing to prescribe for stage 4...
Pembrolizumab (Keytruda). Pembrolizumab targets PD-1, a receptor on tumor cells, preventing the tumor cells from hiding from the immune system. Pembrolizumab is used to treat metastatic colorectal cancers that have a molecular feature called microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR).
Ref: https://www.cancer.net/cancer-types/colorectal-cancer/types-treatment
Pyro wrote:I got offered keytruda yesterday, I’ve been on regular chemo for about 3 years minus surgery time and everything is held at bay for the time being. A “maybe” tumor in pelvis and lung, they aren’t quite sure. My question is the timing, who stopped chemo that was working well try something different? My thought process is keytruda isn’t a fade away jumper yet, if it doesn’t work I can jump back on the chemo that is working for now. Anyone else do this? I actually feel better I have more options. The PDL-1 score MD Anderson gave my tumor was an 8, you need 1 or high (mutation burden?) to try keytruda. FOLFURI is becoming unbearable, I’ve heard just fatigue with keytruda, what are people’s side effects even if only minimum? Thanks!
Stewsbetty wrote:Pyro wrote:I’m MSI h as well. I have been on Keytruda since September 2017. The side effects (if you don’t have a major reaction) are quite minimal. I was able to go back to work 3 days a week as a teacher. I was completely unable to work while on chemo. In my experience there is absolutely no comparison in the side effects.
Beth
Pyro wrote:Stewsbetty wrote:Pyro wrote:I’m MSI h as well. I have been on Keytruda since September 2017. The side effects (if you don’t have a major reaction) are quite minimal. I was able to go back to work 3 days a week as a teacher. I was completely unable to work while on chemo. In my experience there is absolutely no comparison in the side effects.
Beth
The nurses at my ONC office told me of one major reaction but other than that I hear it’s rare. I had one from erbitux, major kidney pain, what kind of reaction have you heard of?
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