Keytruda

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meatie
Posts: 414
Joined: Wed Aug 20, 2014 8:13 am
Location: San Jose, CA

Keytruda

Postby meatie » Thu Jan 31, 2019 1:06 am

Anyone here has had good results with Keytruda? Side effects? How will are oncologists to prescribe Keytruda?
Mother DX @59 8/14
cln+lvr res 9/14, stage 4
FOLOX+Avs 12-rd 10/14 to 4/15
Reoccurrence, KRAS mutant 11/15
Folfiri 18-rds 11/15-8/16
FOLFIRI with Ramicirumab 28-rds 8/17-9/18
Regorafenib 10/18-10/19
Lonsurf 10/19 onward

Stewsbetty
Posts: 170
Joined: Thu Jul 14, 2016 7:08 am

Re: Keytruda

Postby Stewsbetty » Thu Jan 31, 2019 2:07 am

If you are MSI I think drs very willing to prescribe for stage 4.
I am in Canada. I have been on Keytruda since September 2017. I have had very minimal side effects from it and it has worked wonders in my body. Unfortunately it doesn’t have the same effects for everybody.

Let me know if you have any other specific questions.

Beth
42yo At diagnosis. Female in BC, Canada
Dx: CC ascending
Right Hemi colectomy 06/16 clear margins
Adenocarcinoma 6cm High Grade
pT3 pN2a Stage 3
10 out of 16 lymph involved
MSI-h, Kras mut, Braf wild
Finished chemo Feb. 2017
PET scan showing active area April 2017
July 2017 CT showing LN mass and spread to other LN
Stage 4
Aug 2017 failed Fofiri
Sept 2017 keytruda scans every 3 months showing shrinkage and stability to present
November 2018 CT shows only 1 small tumour left

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O Stoma Mia
Posts: 1600
Joined: Sat Jun 22, 2013 6:29 am

Re: Keytruda

Postby O Stoma Mia » Thu Jan 31, 2019 10:21 am

Hi Meatie -

How is your Mom doing now?

There's a member here from your geographic area who took Keytruda on a clinical trial with good results and minimal side effects for about a year and a half, but then it seemed to stop working. You can read about it here:

tchan8888

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Jack&KatiesMommy
Posts: 605
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: Keytruda

Postby Jack&KatiesMommy » Thu Jan 31, 2019 3:14 pm

Meatie:
I am on it with minimal side effects. I am MSS with a moderate mutation burden (12 mutations) and it is working for me when Folfuri and folfox no longer did. You can search a long post about all of this: "Keytruda Mutation Burden is Key"
Cynthia
Mommy to Jack (8) now (17) and Katie (4) now (13)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection
8/13-12/15 (10) RFAs lungs
5/17: Upper Left Lobe of lung resected.
02/18: 3 new lymph mets lung
05/18: Keytruda (MSS w/Intermediate TMB): NED CEA: 66.4, 39.2, 23.8, 13, 3.5 1.8, 1.0, 2.8 3.9, 5.0, 5.6, 1.5, .8,

plastikos
Posts: 332
Joined: Wed Jan 14, 2015 6:09 am

Re: Keytruda

Postby plastikos » Fri Feb 01, 2019 8:04 am

Yes. I had a good result on Keytruda. See my sig below.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED
2019 NED

stu
Posts: 1264
Joined: Sat Aug 17, 2013 5:46 pm

Re: Keytruda

Postby stu » Fri Feb 01, 2019 8:50 am

Hey Meatie ,
It’s been a long time . How is your mum ?
Take care,
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .

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O Stoma Mia
Posts: 1600
Joined: Sat Jun 22, 2013 6:29 am

Pembrolizumab (Keytruda)

Postby O Stoma Mia » Fri Feb 01, 2019 9:59 am

Stewsbetty wrote:... If you are MSI I think drs very willing to prescribe for stage 4...

I think Stewsbetty is right:
Pembrolizumab (Keytruda). Pembrolizumab targets PD-1, a receptor on tumor cells, preventing the tumor cells from hiding from the immune system. Pembrolizumab is used to treat metastatic colorectal cancers that have a molecular feature called microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR).
Ref: https://www.cancer.net/cancer-types/colorectal-cancer/types-treatment

I think you should be able to find a doctor willing to prescribe Keytruda in this case.

DBF
Posts: 319
Joined: Fri Jun 07, 2013 1:44 pm
Facebook Username: https://www.facebook.com/#!/profile.php?id=1000008
Location: New York

Re: Keytruda

Postby DBF » Fri Feb 01, 2019 7:44 pm

Hi Meatie,

How is your mom doing? I don’t have Keytruda info, but I wanted to send my best wishes.

Donna
6/13 Dx @ 29 Wks pregnant, 42 yo
Adenocarcinoma, mucinous
7/13 C-sec/col resec/part. hysterectomy
8/13 Pulm embolism
8/13 Spread to liver
9/13 Liver resection
FOLFOX
CEA UP
ADAPT: Xeloda/Celebrex
2/14 oopherectomy
10/15 obstruction surg
10/17 Scar tissue removal/vsg surg
2019: NED :D
Mom to 3 boys: 21, 10 & 6

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henry123
Posts: 209
Joined: Sun Oct 08, 2017 3:25 am

Re: Keytruda

Postby henry123 » Mon Feb 04, 2019 11:24 am

Not Keytruda but Nivolumab.
Working well.
46yo M msi-high Lynch +ve
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
4/18 2
Aspirin start
6/18 1.5 CT clear
12/18 1.1 NED
6/19 .9 CT clear
1/20 NED Opdivo stop

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O Stoma Mia
Posts: 1600
Joined: Sat Jun 22, 2013 6:29 am

Re: Keytruda

Postby O Stoma Mia » Tue Feb 05, 2019 3:34 am

Hi Meatie -

Happy Chinese New Year to you and your mother, and best wishes for a healthy and prosperous 2019.

Image

Pyro
Posts: 305
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Keytruda

Postby Pyro » Tue Feb 12, 2019 9:50 am

I got offered keytruda yesterday, I’ve been on regular chemo for about 3 years minus surgery time and everything is held at bay for the time being. A “maybe” tumor in pelvis and lung, they aren’t quite sure. My question is the timing, who stopped chemo that was working well try something different? My thought process is keytruda isn’t a fade away jumper yet, if it doesn’t work I can jump back on the chemo that is working for now. Anyone else do this? I actually feel better I have more options. The PDL-1 score MD Anderson gave my tumor was an 8, you need 1 or high (mutation burden?) to try keytruda. FOLFURI is becoming unbearable, I’ve heard just fatigue with keytruda, what are people’s side effects even if only minimum? Thanks!
Aug 2015- Stage 4 CC with liver Mets(38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not liver surgery candidate
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda fail
Jun 2019 - FOLFURI
Aug 2019 - No more, quality time!

Wonderfullymade
Posts: 140
Joined: Tue Jan 12, 2016 4:33 pm

Re: Keytruda

Postby Wonderfullymade » Tue Feb 12, 2019 1:55 pm

Hi Pyro,
I dont know my PD1 score, but I am msi-h. The side effects I had on Keytruda were being tired, but....I felt quite good after the chemo I had been on, so I think its relative to where you are. The biggest side effect I had was a little over a year I started getting colitis ( actually proctitis because I dont have a colon anymore). It got bad enough I had to take prednisone for it. I believe if you experience anything odd you should tell your onc since they are still trying to understand the effects of messing with your immune system.
Good luck!
Wonderfullymade
DX 3/2015 53
Stage IVa CC w/liver met
BRAF/KRAS wild type MSI-High (MLH1, PMS2) not Lynch
Folfox 3 cycles
5/2015 ER for subtotal colectomomy due to perforated colon, ovary removed
Folfuri/Pantiumumab 5 cycles
8/2015 liver resection, gallbladder removed and new LN
10/2015 CT scan new nodes
10/2015 Pembro started CEA 2.2
5/2017 stable lung things, coltis, lymph nodes stable cea 1/2017 1.1
9/2017 NED CEA 1.1 ( stopped Pembro)
2/2019 ER for DVT/ PE
2/2019 clean CT (NED) CEA 1.1

Stewsbetty
Posts: 170
Joined: Thu Jul 14, 2016 7:08 am

Re: Keytruda

Postby Stewsbetty » Wed Feb 13, 2019 8:30 am

Pyro wrote:I got offered keytruda yesterday, I’ve been on regular chemo for about 3 years minus surgery time and everything is held at bay for the time being. A “maybe” tumor in pelvis and lung, they aren’t quite sure. My question is the timing, who stopped chemo that was working well try something different? My thought process is keytruda isn’t a fade away jumper yet, if it doesn’t work I can jump back on the chemo that is working for now. Anyone else do this? I actually feel better I have more options. The PDL-1 score MD Anderson gave my tumor was an 8, you need 1 or high (mutation burden?) to try keytruda. FOLFURI is becoming unbearable, I’ve heard just fatigue with keytruda, what are people’s side effects even if only minimum? Thanks!


I’m MSI h as well. I have been on Keytruda since September 2017. The side effects (if you don’t have a major reaction) are quite minimal. I was able to go back to work 3 days a week as a teacher. I was completely unable to work while on chemo. In my experience there is absolutely no comparison in the side effects.

Beth
42yo At diagnosis. Female in BC, Canada
Dx: CC ascending
Right Hemi colectomy 06/16 clear margins
Adenocarcinoma 6cm High Grade
pT3 pN2a Stage 3
10 out of 16 lymph involved
MSI-h, Kras mut, Braf wild
Finished chemo Feb. 2017
PET scan showing active area April 2017
July 2017 CT showing LN mass and spread to other LN
Stage 4
Aug 2017 failed Fofiri
Sept 2017 keytruda scans every 3 months showing shrinkage and stability to present
November 2018 CT shows only 1 small tumour left

Pyro
Posts: 305
Joined: Mon Oct 12, 2015 7:40 pm
Location: Tucson, AZ

Re: Keytruda

Postby Pyro » Wed Feb 13, 2019 9:28 am

Stewsbetty wrote:
Pyro wrote:I’m MSI h as well. I have been on Keytruda since September 2017. The side effects (if you don’t have a major reaction) are quite minimal. I was able to go back to work 3 days a week as a teacher. I was completely unable to work while on chemo. In my experience there is absolutely no comparison in the side effects.

Beth


The nurses at my ONC office told me of one major reaction but other than that I hear it’s rare. I had one from erbitux, major kidney pain, what kind of reaction have you heard of?
Aug 2015- Stage 4 CC with liver Mets(38/m)
Sep 2015- Avastin/Folfox/Iron
Dec 2015-Not liver surgery candidate
Jan 2016- Erbitux/Folfiri, 2nd opinion at MDA in TX
Feb 2016 -MDA liver surgery
Mar 2016 -30% of left lobe rem, PVE
May 2016 - 70% of liver rem
Jun 2016-Rad
Jan 2017-perm colost @MDA
Jul 2017-Erb/FOLFURI
Nov 2017 -Lung & Liver ablations@MDA
Jan 2018 -Xeloda & Avastin mx
Jul 2018-Avast/FOLFURI
Sep 2018-Rad
Mar 2019 - Keytruda fail
Jun 2019 - FOLFURI
Aug 2019 - No more, quality time!

Stewsbetty
Posts: 170
Joined: Thu Jul 14, 2016 7:08 am

Re: Keytruda

Postby Stewsbetty » Sun Feb 17, 2019 9:05 am

Pyro wrote:
Stewsbetty wrote:
Pyro wrote:I’m MSI h as well. I have been on Keytruda since September 2017. The side effects (if you don’t have a major reaction) are quite minimal. I was able to go back to work 3 days a week as a teacher. I was completely unable to work while on chemo. In my experience there is absolutely no comparison in the side effects.

Beth


The nurses at my ONC office told me of one major reaction but other than that I hear it’s rare. I had one from erbitux, major kidney pain, what kind of reaction have you heard of?


The drs watch for any type of “itis” with Keytruda. There are a couple people on a Facebook page I am part of that had to stop after 3-4 treatments because of reactions. Can’t remember exactly what those were but both had a wonderful response with their disease as well. They were treated with steroids and have recovered from their reactions.

The drs will monitor you each time for pneumonitis, colitis, blood tests for your thyroid, probably a few more too. :)
42yo At diagnosis. Female in BC, Canada
Dx: CC ascending
Right Hemi colectomy 06/16 clear margins
Adenocarcinoma 6cm High Grade
pT3 pN2a Stage 3
10 out of 16 lymph involved
MSI-h, Kras mut, Braf wild
Finished chemo Feb. 2017
PET scan showing active area April 2017
July 2017 CT showing LN mass and spread to other LN
Stage 4
Aug 2017 failed Fofiri
Sept 2017 keytruda scans every 3 months showing shrinkage and stability to present
November 2018 CT shows only 1 small tumour left


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