Page 2 of 2

Re: Colon resection small intestine

Posted: Thu Jan 31, 2019 4:30 pm
by Freddy18
Meckel diverticulum was first described in 1598 by the German surgeon Fabricius Hildanus. It was subsequently reported by Lavater in 1672 and by the Dutch anatomist Ruysch in 1701. It was named in 1809 by the German anatomist Johann Friedrich Meckel, who first identified its embryologic origin. Littre reported its presence in an inguinal hernia, and this finding is now called a Littre hernia. The presence of heterotopic pancreatic and gastric mucosa was identified by Zenker in 1861 and by Salzer in 1904.

What other disease/condition shares some of these symptoms?
Other intraabdominal pathologic conditions mimicking the various clinical presentations of Meckel diverticulum include acute appendicitis, inflammatory bowel disease, intestinal duplication cyst or solitary intestinal diverticulum, peptic ulcer disease, gastroenteritis, biliary colic, diverticulitis, or rarely cavitating malignancies of the gastrointestinal tract, such as lymphoma.

What caused this disease to develop at this time?
Meckel diverticulum is frequently asymptomatic. It is not clear why ectopic, acid-secreting mucosa suddenly results in ulceration and hemorrhage in some individuals and not in others. A role for Helicobacter pylori has been suggested in the pathogenesis of complications, but no convincing evidence has been found to date. Malignancy is rarely reported in association with Meckel diverticulum, the most common being carcinoid tumor. There is an increased incidence of Meckel diverticulum in patients with Crohn's disease, reasons for which remain unclear.

What laboratory studies should you request to help confirm the diagnosis? How should you interpret the results?
Laboratory studies in cases of Meckel diverticulitis may reveal a high white blood cell count with neutrophilia and bandemia, with or without a positive stool guaiac test result. Metabolic acidosis with low serum bicarbonate (HCO3) may be seen in presentations with perforation and peritonitis.

Chronic presentations may include iron deficiency anemia and low ferritin levels due to ongoing blood loss or megaloblastic anemia due to vitamin B12 malabsorption, secondary to dilation and stasis in adjacent ileal loops, depending on the severity and chronicity of symptoms.

Would imaging studies be helpful? If so, which ones?
Meckel diverticulum can be difficult to diagnose, especially in the adolescent population. Radiologic evaluation should be tailored toward the age of the patient and clinical presentation. Angiography and sometimes red blood cell scintigraphy can be useful for localization of bleeding in a patient with lower gastrointestinal bleeding; however, neither study is specific for the diagnosis of Meckel diverticulum. More common approaches are as follows:

Scintigraphy: The diagnosis of a bleeding Meckel diverticulum may be made with a radiolabeled technetium scan, commonly referred to as Meckel scan, because of the high affinity of 99mTc-pertechnetate to the mucus-secreting gastric mucosa cells. A positive scan shows abnormal uptake of the isotope outside the stomach and urinary bladder (Figure 3). Pretreatment with substances such as pentagastrin, a histamine H2 inhibitor (e.g., cimetidine) or glucagon will enhance uptake of the radiotracer and should be used if there is strong clinical suspicion after a negative initial study result.

Figure 3.
Technitium Meckel scan.

A Meckel scan has a sensitivity of 85%, a specificity of 95%, and an accuracy of 90%. False-negative results have been reported with rapid intestinal transit time, mucosal ischemia, or necrosis or insufficient gastric mucosa. False-positive results may be seen in cases of intussusception, intestinal duplication, inflammatory bowel disease, arteriovenous malformation, and hydronephrosis.

Ultrasonography: Ultrasonography can be a useful adjunct in patients with a strong clinical suspicion after a negative Meckel scan, or in patients with nonbleeding presentations. Meckel diverticulitis may resemble appendicitis and appears as a cystic tubular structure with a thick irregular hyperechoic internal wall and a hypoechoic external wall. Inverted Meckel diverticulum gives a target-like appearance.

Computed tomography (CT): CT is rarely used as a primary imaging modality; most of the diagnoses made using CT are incidental. Findings suggestive of Meckel diverticulum include a blind-ending tubular structure communicating with the lumen of the small intestine, with or without soft tissue stranding or fluid in the adjacent mesenteric fat. One may see an intraluminal mass in the case of an inverted diverticulum.

Barium enema: Occasionally, a Meckel diverticulum can be diagnosed on contrast enema studies as an incidental finding. In this case, a Meckel diverticulum would be identified as a saccular, blind-ending pouch on the antimesenteric border of the ileum with a characteristic triradiate fold pattern at the junction of diverticulum and ileum. Filling defects within the diverticulum may represent enteroliths, fecoliths, or foreign bodies.

Double-balloon enteroscopy: A few cases of bleeding Meckel diverticulum diagnosed by double-balloon enteroscopy have been described in the literature when other diagnostic modalities were inconclusive.

If you are able to confirm that the patient has a Meckel diverticulum, what treatment should be initiated?
The treatment of choice for Meckel diverticulum is surgical resection, either by diverticulectomy or by segmental intestinal resection and anastomosis. Laparoscopy is our preferred operative approach (Figure 4). Fibrous bands are easily divided, allowing the entire small bowel to be examined.

Figure 4.
Endoscopic resection of Meckel’s diverticulum.

If a diverticulum is present, it is usually located on the antimesenteric border of the distal ileum. Occasionally, the diverticulum may be folded over and kinked by a congenital band or an inflammatory adhesion. These bands or adhesions should be divided along with the vitelline vessels to expose the base of the diverticulum.

If the diverticulum has a narrow and intact base, it may be divided with an endoscopic stapler. If, however, the base of the diverticulum is wide or thickened (suggesting the presence of ectopic tissue) or if there is inflammation or ischemia involving the adjacent ileum, a minimally invasive intestinal resection should be carried out either in an intracorporeal or extracorporeal manner through an umbilical incision. Extracorporeal resection has the added advantage of avoiding potential intraperitoneal spillage and being able to palpate the lesion, especially in cases of a short diverticulum (<1.6 height-diameter ratio).

The transumbilical single trocar laparoscopic approach has been used for resection of Meckel diverticulum and is associated with fewer incisions and lower operative costs

What are the adverse effects associated with each treatment option?
The adverse effects of surgical management of Meckel diverticulum are not different from any other elective surgical intestinal resection.

Of more interest are complications that arise from unrecognized Meckel divertilum. The most common complications related to Meckel’s diverticulum are small bowel obstruction (23%-42%), hemorrhage from peptic ulceration (43%-80%), and diverticulitis (14%-24%).

What are the possible outcomes of Meckel diverticulum?
The reported prevalence of complications related to Meckel diverticulum in adult patients ranges from 26% to 53%, with an incidence of 4% to 16%. The lifetime risk of complications developing is 4% up to the age of 20 years, and the risk decreases with increasing age. Postoperative morbidity after incidental resection varies between 0% and 6%, with significantly increased morbidity after resection of a complicated Meckel diverticulum. Current mortality from Meckel diverticulum is reported as 0.001%.

What causes this disease and how frequent is it?
Meckel diverticulum is the most common anomaly associated with persistence of the omphalomesenteric duct. It is a sac-like remnant arising from the antimesenteric border of the distal ileum resulting from patency of the ileal end and fibrous obliteration of the umbilical end of the vitelline duct.

The omphalomesenteric (vitelline) duct is the embryonic communication between the yolk sac and the primitive gut during the initial weeks of fetal development. As the placental circulation develops, the duct regresses and usually disappears between the fifth and seventh weeks of gestation. Incomplete regression can lead to a spectrum of congenital anomalies, depending on which portion of the omphalomesenteric duct remains patent.

Meckel diverticulum has an estimated prevalence of 0.6% to 4% in the general population. There is no known sex predilection for Meckel diverticulum, although symptoms and complications are more common in male patients, with the male-female ratio being 3:1 for symptomatic patients.

Most (75%) patients with Meckel diverticulum present within the first 2 decades of life, with the majority presenting in the first 2 years. The incidence of heterotopic tissue has been reported to be 6% in asymptomatic diverticula and between 50% and 67% in symptomatic diverticula.

How do these pathogens/genes/exposures cause the disease?
It is not known how the disease is caused.

Re: Colon resection small intestine

Posted: Fri Feb 01, 2019 6:42 pm
by Maggie Nell
Freddy18 wrote:I had intermittent blood in stool so i had a colonoscopy, they said it was clear. I hadn't felt myself in quite a long time, feeling sick and pain when an xray revealed i had a kidney stone then passed it. Then weeks later pain and sickness really bad I went in to hospital by ambulance and in there I had bloods, Xray, CT scan of abdomin which revealed what they discovered turned out to be meckels diverticulum and had to have emergency open surgery small intestine resection in November 2018. I'm recovering but still getting blood in stool at times so I have to have another colonoscopy now in March. Hope all be alright.

Meckel's diverticulum is a normal anatomic variant found in 2% of the population.
You're one of the rare ones, Freddy18!

How did you go at the hospital today?

Re: Colon resection small intestine

Posted: Sat Feb 02, 2019 5:14 am
by Freddy18
I'm going now this Monday instead as last week there was a nurse strike and probably wasn't the best time to go you know. Il let you know how i get on anyway ok. Your from Australia right?

Re: Colon resection small intestine

Posted: Sat Feb 02, 2019 7:02 pm
by Maggie Nell
Nurse's strike! First time in 20 years, crikey!
Yup, I'm in australia. Catch you on the flip side and be well.

Re: Colon resection small intestine

Posted: Sun Feb 03, 2019 5:45 am
by Freddy18
Ok I will keep you posted.

Re: Colon resection small intestine

Posted: Sun Feb 03, 2019 7:15 pm
by macpudd
Hope things work out fro you Freddie, fellow Paddy, I am from the north east and you?

Re: Colon resection small intestine

Posted: Tue Feb 05, 2019 5:39 am
by Freddy18
Thanks. Yea I'm from co.monaghan myself

Re: Colon resection small intestine

Posted: Tue Feb 05, 2019 1:27 pm
by macpudd
Am only up the n2 near Ardee, things not going so well fro me now, but have to say Monaghan gave me a good boost when they beat the Dubs :D.

Re: Colon resection small intestine

Posted: Tue Feb 05, 2019 8:52 pm
by Freddy18
Keep thinking positive man. I Hope you will be feeling better. Yea monaghan surprised everyone when they beat the dubs. Do you follow the soccer?

Re: Colon resection small intestine

Posted: Wed Feb 06, 2019 11:03 am
by macpudd
Followed all kinds of football, Ardee Celtic for a longtime, btu out of touch with it now. Main passion was motorbike racing, always went to Monaghan road races when they were on and all the rest. Cant ride or deive since last year because of the seizrues and brain tumor, but still enjoy it on tv. Whose your fav soccer club.

Re: Colon resection small intestine

Posted: Wed Feb 06, 2019 12:04 pm
by Freddy18
Yea a mate of mine mad into motorbikes and that. I fellow the soccer a bit, support man utd. You need to be into something for a pastime you know I'm watching box sets on Netflix a show called power good enough when you get into it.

Re: Colon resection small intestine

Posted: Wed Feb 06, 2019 2:00 pm
by macpudd
Will have a look at that, thanks Freddy. I always followed Leeds am hoping they get promotde this season and get a go at united again. Bet your delighed Mourinho is gone.

Re: Colon resection small intestine

Posted: Wed Feb 06, 2019 2:49 pm
by Freddy18
Yea mourinho was boring football to watch grinding out 1-0 wins and draws not United's style of football or exciting for anybody to watch. Yea at least there more enjoyable to watch now and back on winning form.