panitumumab/vectibix question

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mpbser
Posts: 905
Joined: Wed Apr 19, 2017 11:52 am

panitumumab/vectibix question

Postby mpbser » Mon Jan 28, 2019 4:25 pm

For those of you who have had panitumumab/vectibix, was your tumor specimen tested for High expression levels of EGFR ligands epiregulin (EREG) and amphiregulin (AREG)? Would like to know because:

http://www.cancernetwork.com/colorectal ... vanced-crc
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

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