Does anyone have any info on TCR trial at NCI?

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teri3
Posts: 405
Joined: Fri Jan 09, 2015 11:03 am

Does anyone have any info on TCR trial at NCI?

Postby teri3 » Tue Jan 22, 2019 9:52 pm

I have been excepted into the TIL trial at NCI but recieved word that they are sending my cells into production for the TCR trial. They feel this might be my better option. Has anyone had experience with this trial? I'm having a hard time finding info on it.
Thanks
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

User avatar
O Stoma Mia
Posts: 1600
Joined: Sat Jun 22, 2013 6:29 am

Re: Does anyone have any info on TCR trial at NCI?

Postby O Stoma Mia » Tue Jan 22, 2019 11:14 pm

teri3 wrote:I have been excepted into the TIL trial at NCI but recieved word that they are sending my cells into production for the TCR trial. They feel this might be my better option. Has anyone had experience with this trial? I'm having a hard time finding info on it.
Thanks
Teri

TCR stands for "T Cell Receptor". You might have better luck finding info on it if you use the full-length keywords in your search. Additionally, if you are only interested in TCR therapy for lung cancer, then it might help to add "lung cancer" to the search string. Also you could add "clinical trial" to the search string.

If you do all of this, then you will find clinical trials such as NCT02133196:

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
https://clinicaltrials.gov/ct2/show/NCT02133196

A brief description of the trial is found on the web page above. If you want more detailed information than that, then you can try contacting the study coordinator at the e-mail or phone number given on the NCT02133196 contacts page:

Contacts
https://clinicaltrials.gov/ct2/show/study/NCT02133196#contacts

. . .

There may also be some information on TCR therapy on prior posts here, for example the post below, where it is suggested that it may take up to 5 months for them to prepare enough TCR cells for your TCR therapy:

https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=59697&p=474357#p474357
Last edited by O Stoma Mia on Wed Jan 23, 2019 8:14 am, edited 1 time in total.

teri3
Posts: 405
Joined: Fri Jan 09, 2015 11:03 am

Re: Does anyone have any info on TCR trial at NCI?

Postby teri3 » Tue Jan 22, 2019 11:39 pm

Thank you. Ive asked the fellow at NCI who is working with me but she is an extremely poor correspondent. Shes supposed to call me in a couple days to discuss my latest scans but I like to be ahead of the game and have some info to know what to ask.
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

sdino
Posts: 70
Joined: Tue Mar 28, 2017 5:32 pm

Re: Does anyone have any info on TCR trial at NCI?

Postby sdino » Wed Jan 23, 2019 12:23 pm

Hi Teri3 - I believe this is the new TIL trial. NCT03412877 Im not sure. We were offered this new trial after we were accepted into the original TIL trial NCT01174121.
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-2.3CM
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/16 to 1/8/17
CT Scans: 5/17 colon & lung met shrinkage,11/17 to 7/19 slight progression
iTCR TIL Trial NCT03412877 4/19 to 5/19 Off trial, - Sept. 2019 doing Original TIL trial NCT01174121
CEA:16-11/16; 0.6-5/17; 5.1-9/18; 5.4-10/18; 26.9-7/19

teri3
Posts: 405
Joined: Fri Jan 09, 2015 11:03 am

Re: Does anyone have any info on TCR trial at NCI?

Postby teri3 » Thu Jan 24, 2019 6:21 am

Thank you sdino! I think you are right, as you know our fellow is a poor correspondent. When does your wife start? They are supposed to be sending my cells to lab end of the month and have a meeting some time this week
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

sdino
Posts: 70
Joined: Tue Mar 28, 2017 5:32 pm

Re: Does anyone have any info on TCR trial at NCI?

Postby sdino » Thu Jan 24, 2019 7:32 am

Hi Teri3 - we have heard crickets from our Fellow. Last week sent CT scan we had in Buffalo and requested an update. This week sent a email asking if we should or not halt chemo for next week, since we have to mail order our Capecitabine which takes several days. Have not heard back from NIH. Last schedule we heard was TIL infusion somewhere mid-March. (Not sure)
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-2.3CM
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/16 to 1/8/17
CT Scans: 5/17 colon & lung met shrinkage,11/17 to 7/19 slight progression
iTCR TIL Trial NCT03412877 4/19 to 5/19 Off trial, - Sept. 2019 doing Original TIL trial NCT01174121
CEA:16-11/16; 0.6-5/17; 5.1-9/18; 5.4-10/18; 26.9-7/19

sdino
Posts: 70
Joined: Tue Mar 28, 2017 5:32 pm

Re: Does anyone have any info on TCR trial at NCI?

Postby sdino » Fri Jan 25, 2019 11:54 am

Well we heard back from NIH today, They want my Wife to start next round of Capecitabine (but they may stop it after only one week) they want her to hold off on Bevacizumab (Avastin) next week, So we have to be getting closer to TIL Infusion. No formal schedule has been determined as of yet.
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-2.3CM
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/16 to 1/8/17
CT Scans: 5/17 colon & lung met shrinkage,11/17 to 7/19 slight progression
iTCR TIL Trial NCT03412877 4/19 to 5/19 Off trial, - Sept. 2019 doing Original TIL trial NCT01174121
CEA:16-11/16; 0.6-5/17; 5.1-9/18; 5.4-10/18; 26.9-7/19


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