***News Stories Thread*** ONGOING 2019

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Beckster
Posts: 374
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

A Multicenter Study of Active Specific Immunotherapy With OncoVax® in Patients With Stage II Colon Cancer

Postby Beckster » Fri May 31, 2019 5:14 am

OncoVAX is an active specific immunotherapeutic (ASI) stimulating a patient's immune response to autologous (patient-specific) tumor cells. It is comprised of sterile, live but non-dividing tumor cells obtained following standard-of-care surgical tumor resection for Stage II colon cancer. Within 35 days following surgery, patients are immunized with OncoVAX to prevent disease recurrence, which is incurable and occurs in up to 35% of patients. Patients are given three vaccinations once per week for three weeks, followed by a booster vaccination after six months.


https://clinicaltrials.gov/ct2/show/study/NCT02448173
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion
1/2/17 to 6/9/17- Xeloda monotherapy
6/17, 12/17, 6/18, 12/18, 6/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1
Clear Colonoscopy 10/17 :D

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

ASCO 2019: Abstract Recommendations From Dr. Wafiq El-Deiry for Colorectal Cancer

Postby CRguy » Fri May 31, 2019 6:34 pm

ASCO 2019: Abstract Recommendations From Dr. Wafiq El-Deiry for Colorectal Cancer
gives a synopsis of some recent papers being presented at ASCO.

direct links can also be accessed by visiting this page :
https://www.practiceupdate.com/expertopinion/4096/2/1?elsca1=emc_enews_daily-digest

Session: Gastrointestinal (Colorectal) Cancer
Monday June 3, 2019; 8:00 AM–11:00 AM

3514 A phase II study of ipilimumab and nivolumab with radiation in microsatellite stable (MSS) metastatic colorectal adenocarcinoma (mCRC). AR Parikh, JW Clark, JY-L Wo, et al

3528 Genomic alterations after EGFR blockade in patients with RAS wild-type metastatic colorectal cancer: Combined tissue and blood-based analysis from SCRUM-Japan GI-SCREEN and GOZILA. Y Nakamura, R Yamashita, W Okamoto, et al

3551 Modulation of autophagy: A phase II study of vorinostat (VOR) plus hydroxychloroquine (HCQ) vs regorafenib (RGF) in chemo-refractory metastatic colorectal cancer (mCRC). SP Arora, LL Tenner, J Sarantopoulos, et al

3565 Survival according to mutations in BRAF, KRAS, or microsatellite instability (MSI-H) after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastases from colorectal cancer. SG Larsen, S Dueland, M Goscinski, et al

Publication Only

e15020 A phase Ib trial to evaluate the safety and efficacy of quinacrine plus capecitabine in patients with refractory metastatic colorectal cancer. A Winer, N Vijayvergia, SJ Cohen, et al

e15054 A phase I clinical trial of fluorouracil (5-FU) + devimistat (CPI-613) combination in previously treated patients (pts) with metastatic colorectal cancer (MCR). CMSPR Lima, AT Alistar, RJ Desnoyers, et al
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

emerging roles for cannabis in cancer symptom management

Postby CRguy » Fri May 31, 2019 6:43 pm

Ahead of the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, we are speaking with Claude Cyr, MD, of McGill University in Montreal, about the emerging roles for cannabis in cancer symptom management. Dr. Cyr will be speaking at an Education Session titled, “Cannabis for Symptom Management,” on Sunday, June 2, at the meeting, which is being held May 31–June 4 in Chicago.

https://www.cancernetwork.com/asco/using-cannabis-palliative-treatment-patients-cancer
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Can statins improve survival in older patients with rectal cancer?

Postby CRguy » Fri May 31, 2019 6:45 pm

In a nutshell

This study investigated whether statins (medication used to lower the cholesterol levels) improve survival of patients with rectal cancer. Researchers suggested that statins improved survival, particularly in older patients.

https://medivizor.com/view_article/28652548
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Regorafenib side effects: how can we prevent them?

Postby CRguy » Fri May 31, 2019 6:47 pm

In a nutshell

This article reviewed the most common side effects of regorafenib (Stivarga) treatment for patients with metastatic (spread) colorectal cancer (mCRC). The author suggested methods to prevent these side effects to increase treatment adherence.

https://medivizor.com/view_article/28748938
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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Green Tea
Posts: 202
Joined: Mon Oct 24, 2016 10:48 am
Location: Nusa Tenggara

ColonSentry blood test for colorectal cancer screening

Postby Green Tea » Mon Jun 10, 2019 2:32 pm

GeneNews Publishes Data on ColonSentry in Colorectal Cancer Risk Assessment
https://www.marketwatch.com/press-release/genenews-publishes-data-on-colonsentry-in-colorectal-cancer-risk-assessment-2019-01-28

    "Study demonstrates validity of blood-based biomarker test as an adjunct method to colon cancer screening tests in non-compliant patient populations"

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Maggie Nell
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Location: Melbourne, Australia

Re: ***News Stories Thread*** ONGOING 2019

Postby Maggie Nell » Sat Jun 15, 2019 8:11 pm

I am the living ... history of one of our more successful efforts to treat and cure cancer in the last 50 years. There are now numerous other efforts, especially to treat childhood malignancies. Awareness of long-term consequences, the concept of survivorship, and the concept of shared decision making are but a few of the inflections in the arc of therapy



The Arc of Therapy: From Cure to Humbling Legacy
https://ascopubs.org/doi/full/10.1200/JCO.19.00666
DX April 2015, @ 54
35mm poorly diff. tumour, incidental finding following emergency r. hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX
July 2019 : pending liver U/S, colonoscopy
rut roh

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Many Advanced Colon Cancers Were 'Born' Ready to Spread

Postby CRguy » Sat Jun 22, 2019 11:32 pm

TUESDAY, June 18, 2019 (HealthDay News) -- In most patients with metastatic colon cancer, the disease may have begun spreading throughout the body very early on -- when the original tumor was no bigger than a poppy seed, a new study suggests.

Metastatic refers to the most advanced stage of cancer, when the original tumor has spread to distant sites in the body.

Traditionally, that's been seen as a "late" event -- the result of a cancer accumulating many mutations that allow it to invade various tissues in the body, said Christina Curtis, lead researcher on the new study.

Her team's findings turn that viewpoint on its head.

Many Advanced Colon Cancers Were 'Born' Ready to Spread
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Yogurt Might Help Men Avoid Colon Cancer

Postby CRguy » Sat Jun 22, 2019 11:35 pm

TUESDAY, June 18, 2019 (HealthDay News) -- Yogurt is a healthy food, and it may also be a cancer fighter, a new study suggests.

Men who had two or more servings of yogurt a week had a 26% lower risk of developing precancerous growths in their colon, a new study reports. Researchers didn't find the same cancer-fighting benefit for women, however.

"These data suggest that other characteristics of yogurt, such as its potential role in altering the natural bacteria in our guts, may have cancer-preventive properties," said researcher Dr. Andrew Chan. He's a professor of medicine at Harvard Medical School in Boston.


Yogurt Might Help Men Avoid Colon Cancer: Study
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Beckster
Posts: 374
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Evolving Strategies for the Management of BRAF-Mutant Metastatic Colorectal Cancer

Postby Beckster » Mon Jun 24, 2019 3:47 pm

Promising clinical trials using combination therapies that inhibit the mitogen-activated protein kinase (MAPK) pathway and alternative active pathways have demonstrated major advances for patients with BRAF V600E–mutated mCRC.


https://www.cancernetwork.com/colorecta ... 67F54E7A36
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion
1/2/17 to 6/9/17- Xeloda monotherapy
6/17, 12/17, 6/18, 12/18, 6/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1
Clear Colonoscopy 10/17 :D

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LPL
Posts: 650
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: ***News Stories Thread*** ONGOING 2019

Postby LPL » Thu Jun 27, 2019 3:30 am

Post ASCO Webinar 2019
Patient friendly info! (59min) https://fightcolorectalcancer.org/fight ... x8EGidDetA
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma pt 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a Stage IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung
:!: Steroid induced hyperglycemia dx after 3chemo
Surgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb lung met

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

Postby CRguy » Thu Jun 27, 2019 9:05 pm

The I-PREDICT study :
https://www.nature.com/articles/s41591-019-0407-5

Abstract :
Cancer treatments have evolved from indiscriminate cytotoxic agents to selective genome- and immune-targeted drugs that have transformed the outcomes of some malignancies. Tumor complexity and heterogeneity suggest that the ‘precision medicine’ paradigm of cancer therapy requires treatment to be personalized to the individual patient. To date, precision oncology trials have been based on molecular matching with predetermined monotherapies. Several of these trials have been hindered by very low matching rates, often in the 5–10% range15, and low response rates. Low matching rates may be due to the use of limited gene panels, restrictive molecular matching algorithms, lack of drug availability, or the deterioration and death of end-stage patients before therapy can be implemented.

We hypothesized that personalized treatment with combination therapies would improve outcomes in patients with refractory malignancies. As a first test of this concept, we implemented a cross-institutional prospective study (I-PREDICT, NCT02534675) that used tumor DNA sequencing and timely recommendations for individualized treatment with combination therapies.

We found that administration of customized multidrug regimens was feasible, with 49% of consented patients receiving personalized treatment. Targeting of a larger fraction of identified molecular alterations, yielding a higher ‘matching score’, was correlated with significantly improved disease control rates, as well as longer progression-free and overall survival rates, compared to targeting of fewer somatic alterations. Our findings suggest that the current clinical trial paradigm for precision oncology, which pairs one driver mutation with one drug, may be optimized by treating molecularly complex and heterogeneous cancers with combinations of customized agents.
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Cancer Survivors May Have Lower Odds for Dementia

Postby CRguy » Thu Jun 27, 2019 9:19 pm

FRIDAY, June 21, 2019 (HealthDay News)
Researchers have found more evidence of a puzzling phenomenon: Older adults who survive cancer seem to be somewhat protected against dementia.
A number of studies in recent years have found that cancer survivors have a relatively lower risk of developing Alzheimer's.
The new research adds another layer. It shows that even before their diagnosis, older adults who go on to develop cancer have an edge when it comes to memory performance.
Among the older Americans who were tracked for 16 years, those who developed cancer typically had sharper memory skills -- both before and after the diagnosis -- than those who remained cancer-free.

Researchers said it all supports the theory that some of the biological processes that contribute to cancer may actually protect against dementia.


https://www.cancercompass.com/cancer-ne ... NL20190626
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9956
Joined: Sun Feb 10, 2008 6:00 pm

Statins May Lower Risk of Stroke After Cancer Radiotherapy

Postby CRguy » Thu Jun 27, 2019 9:22 pm

WEDNESDAY, June 19, 2019 (HealthDay News) -- Radiation treatment for cancer can damage the heart and blood vessels, increasing the risk for a stroke or heart attack. But a new study suggests cholesterol-lowering drugs can significantly reduce that risk.
The researchers reported that taking statins may lower the risk of a stroke after radiation treatment by 32%.

"Our study demonstrated that statin therapy could be favorable even with the competing risks of cancer and cancer-related mortality in patients who received radiation therapy," said lead researcher Dr. Negareh Mousavi, of McGill University Health Center in Montreal, Canada.
Nothing else has been shown to reduce the risk of stroke after radiation to the head, neck or chest, she said.

Radiation therapy can cause arteries to scar or thicken, leading to blockages that result in heart attacks and strokes, Mousavi explained. Strokes and heart attacks are the main cause of illness and death among cancer survivors, she noted.
Statin drugs work by keeping plaques from building up in blood vessels, preventing blockages.


https://www.cancercompass.com/cancer-ne ... NL20190626
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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Maggie Nell
Posts: 1134
Joined: Wed May 27, 2015 1:57 am
Location: Melbourne, Australia

Re: ***News Stories Thread*** ONGOING 2019

Postby Maggie Nell » Mon Jul 01, 2019 1:08 am

Therese, who asked that we didn't use her real name, is another woman with faecal incontinence who struggled before finally seeking help.

"What it brings up for me is that whole thing of the smelly older woman," she said. [...]

Dr Mirbagheri said the first step when treating someone with faecal incontinence was to rule out any physical abnormalities that may be able to be corrected, as well as screen for more sinister but less common causes.

For example, bowel cancer symptoms can overlap with faecal incontinence.

Next comes a pathway of investigations that may include imaging, endoscopy, colonoscopy or examinations under anaesthetic to look for underlying anatomical factors that may be contributing to symptoms.



Faecal incontinence, or bowel leakage, can be intensely embarrassing. Here's how it's treated (in Australia)

https://www.abc.net.au/news/health/2019 ... t/11245486
DX April 2015, @ 54
35mm poorly diff. tumour, incidental finding following emergency r. hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX
July 2019 : pending liver U/S, colonoscopy
rut roh


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