***News Stories Thread*** ONGOING 2019

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Beckster
Posts: 367
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

A Multicenter Study of Active Specific Immunotherapy With OncoVax® in Patients With Stage II Colon Cancer

Postby Beckster » Fri May 31, 2019 5:14 am

OncoVAX is an active specific immunotherapeutic (ASI) stimulating a patient's immune response to autologous (patient-specific) tumor cells. It is comprised of sterile, live but non-dividing tumor cells obtained following standard-of-care surgical tumor resection for Stage II colon cancer. Within 35 days following surgery, patients are immunized with OncoVAX to prevent disease recurrence, which is incurable and occurs in up to 35% of patients. Patients are given three vaccinations once per week for three weeks, followed by a booster vaccination after six months.


https://clinicaltrials.gov/ct2/show/study/NCT02448173
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion
1/2/17 to 6/9/17- Xeloda monotherapy
6/17, 12/17, 6/18, 12/18, 6/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1
Clear Colonoscopy 10/17 :D

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CRguy
Posts: 9899
Joined: Sun Feb 10, 2008 6:00 pm

ASCO 2019: Abstract Recommendations From Dr. Wafiq El-Deiry for Colorectal Cancer

Postby CRguy » Fri May 31, 2019 6:34 pm

ASCO 2019: Abstract Recommendations From Dr. Wafiq El-Deiry for Colorectal Cancer
gives a synopsis of some recent papers being presented at ASCO.

direct links can also be accessed by visiting this page :
https://www.practiceupdate.com/expertopinion/4096/2/1?elsca1=emc_enews_daily-digest

Session: Gastrointestinal (Colorectal) Cancer
Monday June 3, 2019; 8:00 AM–11:00 AM

3514 A phase II study of ipilimumab and nivolumab with radiation in microsatellite stable (MSS) metastatic colorectal adenocarcinoma (mCRC). AR Parikh, JW Clark, JY-L Wo, et al

3528 Genomic alterations after EGFR blockade in patients with RAS wild-type metastatic colorectal cancer: Combined tissue and blood-based analysis from SCRUM-Japan GI-SCREEN and GOZILA. Y Nakamura, R Yamashita, W Okamoto, et al

3551 Modulation of autophagy: A phase II study of vorinostat (VOR) plus hydroxychloroquine (HCQ) vs regorafenib (RGF) in chemo-refractory metastatic colorectal cancer (mCRC). SP Arora, LL Tenner, J Sarantopoulos, et al

3565 Survival according to mutations in BRAF, KRAS, or microsatellite instability (MSI-H) after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastases from colorectal cancer. SG Larsen, S Dueland, M Goscinski, et al

Publication Only

e15020 A phase Ib trial to evaluate the safety and efficacy of quinacrine plus capecitabine in patients with refractory metastatic colorectal cancer. A Winer, N Vijayvergia, SJ Cohen, et al

e15054 A phase I clinical trial of fluorouracil (5-FU) + devimistat (CPI-613) combination in previously treated patients (pts) with metastatic colorectal cancer (MCR). CMSPR Lima, AT Alistar, RJ Desnoyers, et al
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9899
Joined: Sun Feb 10, 2008 6:00 pm

emerging roles for cannabis in cancer symptom management

Postby CRguy » Fri May 31, 2019 6:43 pm

Ahead of the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, we are speaking with Claude Cyr, MD, of McGill University in Montreal, about the emerging roles for cannabis in cancer symptom management. Dr. Cyr will be speaking at an Education Session titled, “Cannabis for Symptom Management,” on Sunday, June 2, at the meeting, which is being held May 31–June 4 in Chicago.

https://www.cancernetwork.com/asco/using-cannabis-palliative-treatment-patients-cancer
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

User avatar
CRguy
Posts: 9899
Joined: Sun Feb 10, 2008 6:00 pm

Can statins improve survival in older patients with rectal cancer?

Postby CRguy » Fri May 31, 2019 6:45 pm

In a nutshell

This study investigated whether statins (medication used to lower the cholesterol levels) improve survival of patients with rectal cancer. Researchers suggested that statins improved survival, particularly in older patients.

https://medivizor.com/view_article/28652548
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 9899
Joined: Sun Feb 10, 2008 6:00 pm

Regorafenib side effects: how can we prevent them?

Postby CRguy » Fri May 31, 2019 6:47 pm

In a nutshell

This article reviewed the most common side effects of regorafenib (Stivarga) treatment for patients with metastatic (spread) colorectal cancer (mCRC). The author suggested methods to prevent these side effects to increase treatment adherence.

https://medivizor.com/view_article/28748938
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Green Tea
Posts: 187
Joined: Mon Oct 24, 2016 10:48 am

ColonSentry blood test for colorectal cancer screening

Postby Green Tea » Mon Jun 10, 2019 2:32 pm

GeneNews Publishes Data on ColonSentry in Colorectal Cancer Risk Assessment
https://www.marketwatch.com/press-release/genenews-publishes-data-on-colonsentry-in-colorectal-cancer-risk-assessment-2019-01-28

    "Study demonstrates validity of blood-based biomarker test as an adjunct method to colon cancer screening tests in non-compliant patient populations"

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Maggie Nell
Posts: 1083
Joined: Wed May 27, 2015 1:57 am
Location: Melbourne, Australia

Re: ***News Stories Thread*** ONGOING 2019

Postby Maggie Nell » Sat Jun 15, 2019 8:11 pm

I am the living ... history of one of our more successful efforts to treat and cure cancer in the last 50 years. There are now numerous other efforts, especially to treat childhood malignancies. Awareness of long-term consequences, the concept of survivorship, and the concept of shared decision making are but a few of the inflections in the arc of therapy



The Arc of Therapy: From Cure to Humbling Legacy
https://ascopubs.org/doi/full/10.1200/JCO.19.00666
DX April 2015, @ 54
35mm poorly diff. tumour, incidental finding following emergency r. hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX

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CRguy
Posts: 9899
Joined: Sun Feb 10, 2008 6:00 pm

Many Advanced Colon Cancers Were 'Born' Ready to Spread

Postby CRguy » Sat Jun 22, 2019 11:32 pm

TUESDAY, June 18, 2019 (HealthDay News) -- In most patients with metastatic colon cancer, the disease may have begun spreading throughout the body very early on -- when the original tumor was no bigger than a poppy seed, a new study suggests.

Metastatic refers to the most advanced stage of cancer, when the original tumor has spread to distant sites in the body.

Traditionally, that's been seen as a "late" event -- the result of a cancer accumulating many mutations that allow it to invade various tissues in the body, said Christina Curtis, lead researcher on the new study.

Her team's findings turn that viewpoint on its head.

Many Advanced Colon Cancers Were 'Born' Ready to Spread
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

User avatar
CRguy
Posts: 9899
Joined: Sun Feb 10, 2008 6:00 pm

Yogurt Might Help Men Avoid Colon Cancer

Postby CRguy » Sat Jun 22, 2019 11:35 pm

TUESDAY, June 18, 2019 (HealthDay News) -- Yogurt is a healthy food, and it may also be a cancer fighter, a new study suggests.

Men who had two or more servings of yogurt a week had a 26% lower risk of developing precancerous growths in their colon, a new study reports. Researchers didn't find the same cancer-fighting benefit for women, however.

"These data suggest that other characteristics of yogurt, such as its potential role in altering the natural bacteria in our guts, may have cancer-preventive properties," said researcher Dr. Andrew Chan. He's a professor of medicine at Harvard Medical School in Boston.


Yogurt Might Help Men Avoid Colon Cancer: Study
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Beckster
Posts: 367
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Evolving Strategies for the Management of BRAF-Mutant Metastatic Colorectal Cancer

Postby Beckster » Mon Jun 24, 2019 3:47 pm

Promising clinical trials using combination therapies that inhibit the mitogen-activated protein kinase (MAPK) pathway and alternative active pathways have demonstrated major advances for patients with BRAF V600E–mutated mCRC.


https://www.cancernetwork.com/colorecta ... 67F54E7A36
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion
1/2/17 to 6/9/17- Xeloda monotherapy
6/17, 12/17, 6/18, 12/18, 6/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1
Clear Colonoscopy 10/17 :D


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