***News Stories Thread*** ONGOING 2019

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CRguy
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***News Stories Thread*** ONGOING 2019

Postby CRguy » Fri Jan 04, 2019 7:49 pm

To continue a great ColonTalk tradition ....... the 2019 NEWS topic !!!!!
AND in the words of its founder garbovatwin I will start things with the original intro from each year !!!!
Countdown to the Ongoing News Thread has begun.
May all YOUR news be GOOD.

For many of us, be it due to our busy schedules or our demanding treatment and surgeries, we can so easily miss out on a story that we could have/should have seen.

So, here you have it, an ONGOING News Thread where everyone can and probably should consider posting any news stories they deem important, RATHER than adding them to the general support topic thread, where they will clutter up and at times bury important posts for advice and support from fellow CRC members and family.

Please try to post THE LINK TO THE NEWS STORY ONLY to avoid any issues with re-posting copyrighted material.

Just click on the POST REPLY BUTTON
COPY FROM THE NEWS STORY THE LINK TO THE STORY
PASTE the link in the body of the post
COPY FROM THE NEWS STORY THE TITLE UNDER THE LINK
PASTE the title in SUBJECT box

Good health and happiness to all.

garbovatwin


AND
Yet again, we thank you for all your work in keeping us up to date with recent events !
We have made this topic a "sticky" to keep it where everyone will know where to find it.

Once the year ends, we let the old News Topic float back down the page.
Previous ONGOING News Topics can be found here 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010

ALL Members please note that although garbovatwin has authored much of this topic... it is definitely for all members to use, so please keep it active, as instructed in the previous posting.

Best wishes to everyone for 2019

CRguy


UPDATED :

The following sites have proven to be reliable resources for cancer related information, much of which has appeared in this very topic !
Many of them will have "opt in" free account options so you may receive emails of any new releases or updates.
Some may have paid subscription options which members here need to review, if they need a more in depth focus.
( i.e. you can get the abstract from scientific papers with a free login BUTT need to pay to receive the whole article or publication. )

disclaimer : I use many of these sites regularly and receive their updates so I offer these links to share with ColonTalk members for their own specific needs and interests. I still think THIS forum = ColonTalk is the best general resource for anyone having to deal with the CRC Journey.
Members need to assess whether these links are suitable for their own purposes and can let us know if you have any problems with content or functionality.

https://www.ncbi.nlm.nih.gov/ncbisearch/advanced

https://www.cancer.org/

https://www.genomeweb.com/

http://www.theonc.org/

http://www.researchtopractice.com

http://www.aicr.org/

https://www.practiceupdate.com/explore/

http://www.oncotherapynetwork.com/

http://www.cancernetwork.com

https://www.websurg.com/

https://www.nccn.org/default.aspx

http://www.jnccn.org/

http://www.thelancet.com

https://www.securingindustry.com/

https://www.deepdyve.com/

https://www.medscape.com/today

https://www.nejm.org/

https://www.mskcc.org/

https://www.cancercompass.com/cancer-news.htm

https://www.eattobeat.org/evidence

https://www.onclive.com

Cheers
CRguy

NHMike
Posts: 1907
Joined: Fri Jul 21, 2017 3:43 am

WSJ: Cancer Deaths Decline 27% Over 25 Years

Postby NHMike » Tue Jan 08, 2019 11:09 am

For most of the 20th century, overall cancer deaths rose, driven mainly by men dying from lung cancer, researchers noted. But since the peak in 1991, the death rate has steadily dropped 1.5% a year through 2016, primarily because of long-running efforts to reduce smoking as well as advances in detection and treatment of cancer at earlier stages, when prognosis for recovery is generally better.

https://www.wsj.com/articles/cancer-dea ... malertNEWS
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

Growing new blood cells

Postby CRguy » Fri Jan 18, 2019 6:56 pm

“It’s never been done before,” said Dr. Josef Penninger, the new director of UBC’s Life Sciences Institute. He said it’s a game changer because it can be used by clinicians to first prevent damage to blood vessels and maybe eventually reverse the damage.

He said the application would be far reaching even just among diagnosed diabetes, who number 420 million worldwide. He said there are an additional 500 million people who are likely to develop the disease.

He said growing healthy cell walls would also be beneficial for treating a number of other diseases, including heart disease, cancer and non-healing wounds, because the lack of the blood system to deliver oxygen and nutrients to the body parts affected by those diseases is what usually kills patients.


UBC grows 'perfect' blood cells, hopes it will help with diabetes and more
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Beckster
Posts: 332
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Could an MUC1-Targeted Vaccine Benefit Colorectal Cancer Patients With Liver Mets?

Postby Beckster » Fri Jan 25, 2019 10:24 am

This was just posted in the "Cancer Network..home of the journal of oncology"

http://www.cancernetwork.com/asco-gi/co ... 67F54E7A36

link fixed - ccmc
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size: 3.5 cm x 2.5 x 0.7 cm
Grade: G3 (surgical) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion-discontinued
1/2/17 to 6/9/17- Xeloda monotherapy
6/17, 12/17, 6/18, 12/18 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5
Clear Colonoscopy 10/17 :D

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

from the ASCO GI 2019: Conference Coverage

Postby CRguy » Fri Jan 25, 2019 8:17 pm

ASCO GI 2019:

ASCO GI 2019: Polymorphisms in the Telomerase Complex Prove Predictive in Metastatic Colorectal Cancer
January 19, 2019—San Francisco, California—Single nucleotide polymorphisms (SNPs) in core telomerase/telomere capping complex genes may hold predictive and prognostic value in patients with metastatic colorectal cancer (mCRC) receiving targeted first-line treatments.



ASCO GI 2019: Genetic Variants in the Lipopolysaccharide Receptor Complex, as well as TLR4 Expression Levels, Prove Predictive in Metastatic Colorectal Cancer
January 19, 2019—San Francisco, California—Polymorphisms in the lipopolysaccharide (LPS) receptor complex and TLR4 expression levels may hold a predictive value in patients with mCRC receiving first-line cetuximab-based treatment. These polymorphisms and TLR4 expression levels may contribute to resistance to anti-epidermal growth factor receptor (EGFR) agents.

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

CRS / HIPEC in younger patients

Postby CRguy » Sun Jan 27, 2019 3:48 pm

Annals of Surgical Oncology, Volume OnlineFirst – Jan 14, 2019

More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy ( CRS/HIPEC)

abstract found here ( to view, close the login screen if it appears by clicking the X at the top right )

requires login for full article

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

Too Much TV Raises Women's Odds for Early-Onset Colon Cancer: Study

Postby CRguy » Thu Feb 07, 2019 7:33 pm

Too Much TV Raises Women's Odds for Early-Onset Colon Cancer: Study
The investigators found 118 cases of "young-onset" colon cancer -- diagnosed under age 50 -- occurring over two decades of follow-up.

The study couldn't prove cause and effect. But it found that women who'd watched more than an hour of TV a day had a 12 percent increased risk of colorectal cancer, compared with those who spent less time in front of the TV. That number rose to 70 percent for those who watched more than two hours of TV daily, the study authors said.

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

Canine Bone Cancer Vaccine Hints at a Human Version

Postby CRguy » Thu Feb 07, 2019 7:40 pm

Canine Bone Cancer Vaccine Hints at a Human Version

"After we remove the tumor, we create a vaccine using the dog's tumor cells to stimulate anti-tumor lymphocytes, that are then transfused into the dog,......These cells are activated and essentially really angry at whatever they are supposed to attack. When put back into the body, they should identify and destroy tumor cells. Ideally, this immune response would destroy every last tumor cell,"......

The team plans to continue its research with the goal of eventually conducting clinical trials of the vaccine therapy to treat bone cancer and other types of cancers in people.

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

AICR Diet and Cancer Report and Organic food study

Postby CRguy » Fri Feb 08, 2019 4:56 pm

Diet, Nutrition, Physical Activity and Cancer: A Global Perspective, our Third Expert Report,
is AICR/WCRF’s most comprehensive scientific report to date.
http://www.aicr.org/cancer-research/die ... about.html


Organic Foods and Cancer Risk: Separating Myth from Fact
https://blog.aicr.org/2019/02/05/organi ... from-fact/

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Maggie Nell
Posts: 975
Joined: Wed May 27, 2015 1:57 am
Location: Melbourne, Australia

Why Some Patients Make My Heart Sink

Postby Maggie Nell » Sun Feb 10, 2019 1:12 am

As GPs we use the term ‘heartsink’ to describe a certain group of patients. These are patients who pull the life out of you. They are often manipulative and time-consuming, and attend frequently. When you see their name on your clinic list you sigh, and sometimes have a physical reaction: a ‘heartsink’. They are people we try to help but feel we get nowhere with. [...]

Unreasonable demands that play on my mind

The people who really make my heart sink are patients who manipulate me, are persistently unreasonable in their demands of me or the wider NHS, or who are rude and complain frequently. These patients play on my mind and I continue to think about them a long time after the consultation has finished.


https://wellcomecollection.org/articles ... UAAALennpd


Not everyone is cut out for the demands of being a primary physician but will they throw in the towel and take up pottery? Nooooooooo :roll: :evil:
DX April 2015, @ 54
35mm poorly diff. tumour, incidental finding following emergency r. hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

A few CRC items from Medivizor

Postby CRguy » Fri Feb 15, 2019 12:30 am

Can CEA levels predict tumor response to treatment in advanced colorectal cancer?
https://medivizor.com/view_article/23861865?id=29657

Regorafenib followed by cetuximab is associated with longer survival in the treatment of advanced colorectal cancer
https://medivizor.com/view_article/23165453?id=30336

Hypofractionated stereotactic radiotherapy improves outcomes in advanced colorectal cancer
https://medivizor.com/view_article/22757237?id=30332

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

Use of Adjuvant Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma

Postby CRguy » Wed Feb 20, 2019 6:33 pm

Abstract about benefit of oxaliplatin for Stage III

Use of Adjuvant Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma

TAKE-HOME MESSAGE

This analysis of data from the National Cancer Data Base was designed to evaluate the use of adjuvant oxaliplatin for patients with stage II or III rectal adenocarcinoma. Doublet chemotherapy was associated with improved overall survival among those with pathological stage III disease. This benefit was not seen among patients with clinical stage II disease who then progressed to pathological stage III disease. Doublet therapy was not associated with improved survival among those with pathological stage 0 or I disease.

The use of adjuvant oxaliplatin confers survival benefit for patients with stage III rectal adenocarcinoma.

– Neil Majithia, MD

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CRguy
Posts: 9786
Joined: Sun Feb 10, 2008 6:00 pm

Young-Onset Colorectal Cancer: Are We Missing Key Clues?

Postby CRguy » Mon Feb 25, 2019 4:55 pm

The researchers noted that the increases were particularly apparent in six of the 12 obesity-related cancer types in patients aged 25-49 years. Colorectal cancer being one of these. The increasing rates of colorectal cancer in younger adults has been causing alarm and prompted physicians and researchers to investigate the potential causes for this early-onset disease over the past decade.

Author: Christine Sardo Molmenti


Young-Onset Colorectal Cancer: Are We Missing Key Clues?

Jannine
Posts: 118
Joined: Wed Jun 20, 2018 7:46 am

Re: ***News Stories Thread*** ONGOING 2019

Postby Jannine » Thu Feb 28, 2019 4:14 pm

Not directly related to CRC, but definitely relevant for anyone who needs to research scholarly topics but has trouble getting access to scholarly journal articles: The University of California system has announced they are not renewing their subscription to Elsevier journals (a major publisher of hard science and medical journals), and will instead be opting to publish all research in free open access journals.

https://www.universityofcalifornia.edu/ ... s-publicly
DX: sigmoid colon cancer 5/2018. 48 F
laparoscopic sigmoid resection (24 cm removed); no stoma.
7.5cm adenocarcinoma -- mod. diff.
1 noncontiguous tumor deposit removed; 0/31 lymph nodes
T3 pN1c M0
5/18 before surgery, CEA 11.2
6/18 began FOLFOX
7/18: CEA 1.9; added neulasta post infusion
9/18: CEA 2.8
10/18: 25% chemo reduction
11/18: CEA 1.8

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LPL
Posts: 559
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: ***News Stories Thread*** ONGOING 2019

Postby LPL » Thu Feb 28, 2019 6:14 pm

Jannine wrote:Not directly related to CRC, but definitely relevant for anyone who needs to research scholarly topics but has trouble getting access to scholarly journal articles: The University of California system has announced they are not renewing their subscription to Elsevier journals (a major publisher of hard science and medical journals), and will instead be opting to publish all research in free open access journals.

https://www.universityofcalifornia.edu/ ... s-publicly

Good News!!! :)
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma pt 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a Stage IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED for now :D
:!: Steroid induced hyperglycemia dx after 3chemo .. hospitalized, insulin -> Metformin
Surgeries (open):
3/18 Emergency colostomy 5/23 Primary+gallbl+colostomy reversal (+port) 9/01 Liver mets


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