Tinnitus

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SGNYC
Posts: 35
Joined: Mon Sep 03, 2018 9:20 pm

Tinnitus

Postby SGNYC » Sun Dec 09, 2018 9:06 pm

Hi all,

DH finished 8th round of Folfox and went for hearing test bc slight loss and ringing in one ear. He also had 9th round delayed by estimated 5 days due to low platelets. MSK takes a conservative approach to the Oxali when these symptoms emerge especially once one is past 8 rounds amd I expect them to either reduce or even drop the Oxali.

My questions are (1) I’ve seen posts on tinnitus/ringing and wondered if any recent posters have had this esp in combo with slight hearing issues (at upper frequencies only) and (2) I’ve seen posts saying 8 rounds of Oxali is the standard of care in Europe and wanted to get pointed in the right direction to those reports.

Thank you!
Wife to DH, 44
DX July 18 - RC at Rectosigmoid
Adenocarcinoma, Mod diff
T3N1M1
Stage IV (but MSK said not a true Stage IV at Dx)
Pos nodes: 1/18
1 Liver Met and 1 Lung Met - liver Met dead tissue at surgery, hence MSK M1 status
Baseline CEA value of 25, now 3.4
LAR (Robotic)/Liver resect(dead tissue), VATS lung - clear margins
Temp Ileo- Reversal Feb 19
Folfox - 5 Rounds Neoadj, 3 rounds Adj, then discontinued Oxali and 4 rounds just 5FU
NED and Reversal Feb 2019 - clear contrast CT, clear contrast MRI

Gravelyguy
Posts: 309
Joined: Thu Jul 05, 2018 6:03 pm

Re: Tinnitus

Postby Gravelyguy » Mon Dec 10, 2018 6:11 pm

I can’t help too much but just wanted to let you know I have a slight hearing loss and just thought it was me getting older. I never thought to think it could be from the chemo.

I can’t remember where but I do remember reading reports on different amounts of Folfox. Not sure your stage but my oncologist said that all of the studies were for stages 2 and 3. Since I was stage 4 and younger he was pretty adamant that 12 rounds was the way to go.

Dave
6/17 dx mRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0
12/19/19 clear scans CEA 1.0 still NED!
6/17/20 clear scans CEA 1.1 still NED!

SGNYC
Posts: 35
Joined: Mon Sep 03, 2018 9:20 pm

Re: Tinnitus

Postby SGNYC » Tue Dec 11, 2018 11:46 am

Thanks. Yes I hope they can reduce not cut out but with the tinnitus (ototoxicity is a side effect, though not common) and the low platelets, I don’t know how they will handle it.

This far, he’s had a pretty clear recovery/treatment and I keep remonding myself it’s impossible to get thru this without any bumps along the way. This is a small bump but it’s really shaken me up.
Wife to DH, 44
DX July 18 - RC at Rectosigmoid
Adenocarcinoma, Mod diff
T3N1M1
Stage IV (but MSK said not a true Stage IV at Dx)
Pos nodes: 1/18
1 Liver Met and 1 Lung Met - liver Met dead tissue at surgery, hence MSK M1 status
Baseline CEA value of 25, now 3.4
LAR (Robotic)/Liver resect(dead tissue), VATS lung - clear margins
Temp Ileo- Reversal Feb 19
Folfox - 5 Rounds Neoadj, 3 rounds Adj, then discontinued Oxali and 4 rounds just 5FU
NED and Reversal Feb 2019 - clear contrast CT, clear contrast MRI

rockhound
Posts: 113
Joined: Fri Jul 14, 2017 5:00 pm

Re: Tinnitus

Postby rockhound » Tue Dec 11, 2018 5:08 pm

I did six Folfox cycles with no hearing problems. However, a few months after round 6, I developed tinnitus. It's continued over a year now- could be due to listening to music with earbuds for a long time and aging, but I suspect the Oxaliplatin. My oncologist indicates its the chemo.
42 yr old male
Diagnosed December 2016, age 41
Stage 1/IIA rectal cancer - T2/3N0M0 via MRI (MRI indicates stage 1; onc/surgeon = stage 2a)
Lynch syndrome, MSH6 mutation, MSI
2 to 3/2017 Xeloda + Radiation
5/10/17 - Robotic LAR with temp. loop illeostomy, 0/20 lymph nodes
6 to 7/2017 - Six cycles Folfox @ full strength
9/20/17 - Ileostomy takedown
10/17 - CT, NED
1/18 - 5mm polyp removed during colonoscopy
5/18 - CT, NED
11/18 - CT, NED
5/19 - CT, NED..moving to yearly CT scans


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