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nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Sat Dec 01, 2018 10:19 pm
by PeterG
I am not MSI high, hence it was my understanding that, with MSS tumors, I would not be a good candidate for immunotherapy. I have, however, been recruited and approved for a trial at Mass General called nivolumab and ipilimumab and radiation therapy in mss and MSI high colorectal and pancreatic cancer (Ca209-806). Anyone participating? Any insight, information, wisdom or warnings to offer?

Re: nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Sat Dec 01, 2018 10:38 pm
by PeterG

Re: nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Thu Dec 06, 2018 7:25 pm
by henry123
Best of luck.
Hopefully the trial delivers for you.

Re: nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Sun Dec 09, 2018 8:11 pm
by PeterG
Thanks Herry123. I am apparently starting on the 31st, barring any unexpected occurrences. Would love to hear from folks who have been involved with this particula combination of immunotherapy drugs, with or without radiation—or who know more about this trial or other similar trials. Seems promising, and exciting, but I am somewhat unnerved by throwing myself into this basket with no real backup—have to be off any and all chemo or other cancer drugs (on Stivarga until three days ago) and then I have to trust in these Mass General docs, and fate.

Re: nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Tue Dec 11, 2018 9:04 pm
by henry123
PeterG wrote:Thanks Herry123. I am apparently starting on the 31st, barring any unexpected occurrences. Would love to hear from folks who have been involved with this particula combination of immunotherapy drugs, with or without radiation—or who know more about this trial or other similar trials. Seems promising, and exciting, but I am somewhat unnerved by throwing myself into this basket with no real backup—have to be off any and all chemo or other cancer drugs (on Stivarga until three days ago) and then I have to trust in these Mass General docs, and fate.


When I first started on opdivo, it was pretty uncharted territory for even msi cases, so trust and take the plunge.

Re: nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Sun Dec 16, 2018 12:30 am
by PeterG
When I first started on opdivo, it was pretty uncharted territory for even msi cases, so trust and take the plunge.


Thanks Henry123. Somewhat frightening, in that I am not MSI-H, 4.5 years after treatment for metastasis. Checkpoint inhibitors were seemingly out of reach until now. Still not covered by insurance. Surprised no one else on Colon Talk has offered any feedback.

Re: nivolumab + ipilimumab + radiation in mss and MSI high

Posted: Tue Dec 18, 2018 11:09 am
by Jack&KatiesMommy
PeterG:
Do you know what your mutation burden is? Did you have Foundation One testing on your tumor? If you have (now--because years of treatment can cause our cancer to mutate) a moderate mutation burden (12+) then Keytruda may work on you as it does for MSI high patients. Foundation One has a blog on this very result and I am one of the patients studied. I am so fortunate to have been given the opportunity to go down this path. You may be headed for the same!
Cynthia