KRAS G12V - anyone with good news?

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dliu
Posts: 66
Joined: Sun Jun 03, 2018 7:16 am

KRAS G12V - anyone with good news?

Postby dliu » Wed Nov 07, 2018 8:48 am

We just got our genetic testing results and my mum is KRAS G12V mutant. I have been looking online and on this forum but have decided to stop for the sake of my mental health: I don't have a great grasp of scientific papers, and what I read is grim.

Anyone with a bit of good news or perspective on the subject want to chip in?

[EDIT] I should add that we're not US-based, we're in Europe (Italy). Might consider flying to the US for treatment but my mum is very weak at the moment so probably not ready to relocate relatively long-term
Last edited by dliu on Wed Nov 07, 2018 10:06 am, edited 1 time in total.
Caring for my mum, 65
Sigmoid resection, multiple liver mets
09/05/2018 Dx Stage IV, 6/11 LN - KRAS G12V
28/05/2018 First round of FOLFOX + Avastin

CEA down from 6000+ (05/2018) to 843 (08/2018) to 377 (11/2018)
9/10 rounds with Oxaliplatin
8/10 rounds with Bevacizumab

WarriorSpouse
Posts: 196
Joined: Tue Aug 16, 2016 9:02 pm

Re: KRAS G12V - anyone with good news?

Postby WarriorSpouse » Wed Nov 07, 2018 9:09 am

I am sorry to read what you are going through caring for your Mom.

There are many Stage IV survivors here posting every week.
My suggestion is to make sure she gets a second opinion on treatment from a major cancer center if possible. Treatment plans can still be implemented at the local facility as long s the overall plan gets the consent from a major cancer facility.
There is another thread ongoing covering a similar circumstance for KRAS mutant. You may get more reading those posts as well.

Best Wishes,
WS
D/H 47 years old, 10/2014, Stage IV M/CRC, nodes 12/15, para-aortic, 5 cm sigmoid resection, positive Virchow. KRAS mut, MSS, Highly Differentiated, Lynch Neg, 5FU/LV and Avastin 1 YR (Oxi for 5 months), Zeloda/Bev since 01/2016. 02/2019 recurrence para-nodes, back to 5FU/LV Oxy/Bev. It is working again. "...Perseverance is not a long race; it is many short races one after the other."-Walter Elliot

sdino
Posts: 70
Joined: Tue Mar 28, 2017 5:32 pm

Re: KRAS G12V - anyone with good news?

Postby sdino » Wed Nov 07, 2018 9:56 am

Possible clinical trial at NIH/NCI - Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*1101 Patients. link to trial here : https://clinicaltrials.gov/ct2/show/NCT03190941
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-2.3CM
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/16 to 1/8/17
CT Scans: 5/17 colon & lung met shrinkage,11/17 to 7/19 slight progression
iTCR TIL Trial NCT03412877 4/19 to 5/19 Off trial, - Sept. 2019 doing Original TIL trial NCT01174121
CEA:16-11/16; 0.6-5/17; 5.1-9/18; 5.4-10/18; 26.9-7/19


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