I've done 7 of 12 rounds of FOLFIRINOX, which is FOLFOX plus Irenotecan. First 2 rounds were the worst, with terrible vomitting that had me back in the hospital for fluids. Since then I've been given 3 different types of anti-nausea drugs which has stopped the vomitting for these last few rounds.
Outside of nausea I get pins and needles in my fingers an d toes, first bite, constipation for 3-5 days post chemo then it flips to diareah which I can get under control relatively quickly with immodium.
I'm in Ontario and I get 5 days of at home fluids (saline IV) once disconnected from 5FU to help flush out the chemo which has been quite helpful as drinking fluids in the first few days is very difficult for me. Having an IV bag to carry around for 4 hours is annoying but beats the alternative.
My biggest challenge is the Neulasta injection. For 2-3 days post injection I am so uncomfortable with muscle, lymph node and joint pain that I cannot get comfortable to sleep or sit. The oncology nurse says eventually my body will become used to it and react less, but so far that's not been my reality.
In terms of hairloss I've noticed shedding and thinning but everyone around me swears they can't see it. I'm losing eyelashes and eyebrows, but annoyingly the hair on my upper lip has real staying power
Good luck to you!