My DH did all 12 rounds of Folfox, though near the end the Oxy was reduced due to neuropathy. The cold sensitivity didn't bother him much, we just kept a pair of knit gloves by the fridge, in his car, at his job etc to make sure he could snag them when needed. He works in the foodservice industry so whenever he needed to handle cold food products he just put on a pair of latex gloves over his knit ones and that worked well. He was always the most tired the day his pump was removed and the day after, but he always bounced back after hydration a couple of days later. I think the thing that lowered his quality of life the most was the taste changes. First it was just one or two things that tasted off, but it quickly developed into anything that stayed on his tongue longer than a few seconds tasted like a combo of ash and glue paste. For about two months he was on a purely liquid diet because that's all he could stand and it made him miserable. I think it will be a long time before he willingly eats a shake, smoothie or bowl of soup.
As for lasting effects, he has numbness in the soles of his feet and tips of his fingers. It doesn't bother him, though sometimes he says it feels a little odd. He does now have a tendency to drop things now because he can't feel them slipping and that upsets him, so he would say that's the worst part of the neuropathy. Our oncologist said that would hopefully diminish with time though it would take a while, he's also on B vitamins to help with the healing.
Caring for DH John, 41
DX: Colon Cancer, Sigmoid colon
Tumor type: Adenocarcinoma
Tumor grade: G2, Moderately differentiated w/invasion of visceral peritoneum
Positive lymph nodes: 6/22
Chemotherapy: FOLFOX (6)
12/17 ER and emergency surgery
02/18 Hospital w/ MSSA infected port, PICC line inserted, abdominal CT scan clear chest CT scan showed septic emboli & blood clots
03/18 Hospital w/ CDIFF
04/18 Chest CT scan clear
06/18 Colonoscopy Clear
08/18 CT Scan Clear, NEMD