MCV is typically raised by chemo. Various degrees of elevation during chemo are considered by some doctors as an indication of good response to chemo. There is some prior discussion in the archives. Not so sure about raised MCV after heavy duty chemo or damage, but with our immunochemo, MCV falls at the drop of any part of the treatment.
There might be a discussion somewhere about natural folates' depletion and repletion, which is the normal use of MCV off chemo. Synthetic folic acid, a cheap inferior form requiring several conversions in the body to make natural folate, L5MTHF, is not all it is supposed to be for many people. We prefer natural, concentrated folate food sources and this had other benefits in the CBC.
watchful, active researcher and caregiver for stage IVb/c CC since early 2010. 2 surgeries; 8 yrs immuno-Chemo for mCRC, now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher