High alkaline phosphatase?

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crikklekay
Posts: 92
Joined: Thu Feb 15, 2018 9:47 am
Location: Richmond, VA

High alkaline phosphatase?

Postby crikklekay » Thu Oct 04, 2018 12:18 pm

It is hard to believe that it has been a little over a month since my DH last Folfox infusion and he was given a thumbs up and clear CT Scan. The only thing the doctor was concerned about was his alkaline phosphatase levels which had risen during treatment, but it looked like they were coming down. If they start going back up she might want to do a PET scan to make sure nothing is going on in the liver. We've been so busy these last few weeks getting part of our life back and prepping for surgery I didn't really think about it, but he had blood work this week and the number is up from 131 to 140. We're waiting to see if the Oncologist wants to do any imaging before his stoma reversal surgery next week, so I thought I would post the question here- has anyone else struggled with high alkaline phosphatase numbers post chemo? Did they eventually go down? His CEA is still trending down but I'm not sure if that's a good marker for him since it never got over 4.7.
Caring for DH John, 41
DX: Colon Cancer, Sigmoid colon
Tumor type: Adenocarcinoma
Tumor grade: G2, Moderately differentiated w/invasion of visceral peritoneum
Stage IIIC
Positive lymph nodes: 6/22
Chemotherapy: FOLFOX (6)
12/17 ER and emergency surgery
02/18 Hospital w/ MSSA infected port, PICC line inserted, abdominal CT scan clear chest CT scan showed septic emboli & blood clots
03/18 Hospital w/ CDIFF
04/18 Chest CT scan clear
06/18 Colonoscopy Clear
08/18 CT Scan Clear, NEMD
06/19 Colonoscopy Clear

hiker
Posts: 139
Joined: Thu Aug 09, 2018 10:15 am

Re: High alkaline phosphatase?

Postby hiker » Thu Oct 04, 2018 12:33 pm

My alk phos has been all over the place. From a low of 53 the day I went in for liver resection surgery to a high of 234 after my second HAI pump chemo treatment and everywhere in between. I haven't been on chemo since 02/28 of this year and my last lab work on 08/29 showed 161. Not sure what's causing it - could be the neulasta shots I take for low WBC. I've read that it can affect alk phos.

hiker
Colonoscopy 2/17, 5cm tumor descending
Diagnosed stage iv, liver mets 3/17
Colon resection 3/17
Told surgery not an option, get my affairs in order
Meet w/MSK team 5/01/17
Folfox(3rds) 5/17-6/17
Liver resection/implant HAI pump 7/17
HAI pump chemo(5rds) 8/17-2/18
Folfiri+Vectibix(11rds) 8/17-2/18
Spot on chest CT 10/17
Lung biopsy (that was fun) 11/17
Nocardia bacterial infection w/spread to brain (this is serious) 11/17
IV antibiotics 12/17-2/18
Oral antibiotics 3/18-12/18
Clear of cancer since surgery

margiej
Posts: 88
Joined: Sat Apr 14, 2018 8:46 am

Re: High alkaline phosphatase?

Postby margiej » Thu Oct 04, 2018 5:55 pm

Before my final chemo treatment my alk phos was 134. A month after chemo it was still high at 122. My doctor felt it was just from the chemo. Two months later it was down to 84 and six months after that was 73. Hope that is helpful and will be your experience too.
Margie
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/17
CT 10/3/17 clear
CT 10/17/18 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

Tupelo honey
Posts: 42
Joined: Tue Jul 19, 2016 7:57 pm

Re: High alkaline phosphatase?

Postby Tupelo honey » Thu Oct 04, 2018 9:00 pm

Same here. Mine trended up over the last couple of treatments and beyond, up to a high in the 190's a couple months after chemo was over. It came down slowly over the next few months.
Rectal Cancer Stage 3A 10-22-2015 T2N1M0
Start Chemo radiation 11/2015
LAR TME w/ total hysterectomy 3/14/2016 pT2N1M0 No ileo, straight connect
Start Xelox 4/21/16 1 week on/1 week off
Switch to Xelox 2 weeks on/1 week off 6/1/2016
Supplements: Curcumin, PSK, Celixicob, Cimetidime, Glutamine, L-Acytel Carnitine, Vit D, Vit B6, Vit B12, magnesium, calcium, aspirin, metformin, modified citrus pectin
10/2016 NED
03/2017 NED
07/2017 NED
11/2017 NED
05/2018 NED
11/2018 NED
11/2019 NED

retiredteacher
Posts: 108
Joined: Sat Oct 21, 2017 1:34 pm

Re: High alkaline phosphatase?

Postby retiredteacher » Thu Oct 04, 2018 9:37 pm

Yes - mine bumped up to the 180's. I believe it is not uncommon.
RC F 63 9/17
Adeno 7 cm MSS G2 PET
T3N0M0
2.5K Cap/RT x 25
"Near complete response" PET 1/18
CEA 0.5 10/17, 0.6 10/18
MRI 2/18 yT2N0 12 cm fr AV 3 cm
LAR 2/18 yT1N0M0 0/21 G1 0.3 cm
CAPEOX 3/18, reduced to 80% at cycle 3
Completed 4 cycles; stopped, gut issues, liver enzymes
CT/ colonoscopy 11/18 NED
4/19 NED Sacral fractures/osteoporosis
"Caregiver" to the Iron Man
Hubby CRC Stage 3 2004 NED, Small Cell Lung Cancer Limited 2011 NED, Non-small Cell Lung Cancer 2019 NED October 2019

crikklekay
Posts: 92
Joined: Thu Feb 15, 2018 9:47 am
Location: Richmond, VA

Re: High alkaline phosphatase?

Postby crikklekay » Fri Oct 05, 2018 11:08 am

Oh good! We were told it was normal for it to go up during treatment but that it should "go down after chemo ends" but I was never given a time window to expect. So when I saw it went up my brain was going "Wait, isn't that supposed to be a smaller number??". The oncologist said since it wasn't a large increase and his other numbers are good that she's happy with everything, it should hopefully be a little lower again next month. On to reversal surgery next week! I'm a bundle of nerves, but my DH can't wait to be reconnected. His time with an ostomy has been very rough.
Caring for DH John, 41
DX: Colon Cancer, Sigmoid colon
Tumor type: Adenocarcinoma
Tumor grade: G2, Moderately differentiated w/invasion of visceral peritoneum
Stage IIIC
Positive lymph nodes: 6/22
Chemotherapy: FOLFOX (6)
12/17 ER and emergency surgery
02/18 Hospital w/ MSSA infected port, PICC line inserted, abdominal CT scan clear chest CT scan showed septic emboli & blood clots
03/18 Hospital w/ CDIFF
04/18 Chest CT scan clear
06/18 Colonoscopy Clear
08/18 CT Scan Clear, NEMD
06/19 Colonoscopy Clear


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