I have been a member for a while, read here and there, but never posted. I've done a little searching on the topic but thought it may be useful to start a new thread on this. As you can see from my signature, I have been through a lot of tx since being diagnosed in July of 14. I have only distant lymph node spread currently (in supraclavicular node, and a few para-aortic and common illiac node). Activity isn't really high (<5 for the para aortic and common illiac) but the supraclavicular is a new one, PET SUV of 5, so definitely considered progression. Therefore my oncologist suggested we change up the chemo to folfiri + vectibix.
Has anyone here been on vectibix & folfiri and did they see significant results? I am hesitant going on such an aggressive regimen, especially with the rash, but also want to keep things under control so that local treatments to these nodes could be a possibility in the future.
We have done a good job of controlling further spread thus far but the new node in the supraclavicular area indicates either resistance or the chemo wasn't 'working' as planned. The surgery/radiation to get rid of the para-aortic lymph nodes was not entirely successful. My oncologist has stressed that the longer we can keep these things under control, buy time, the more likely it is a new breakthrough treatment will come out to help all of us!
Any feedback would be appreciated, even if you are on vectibix for organ mets, not just lymph node mets.
dx '14, stage IIIc sigmoid cc
colectomy, 12 folfox
7/15, stage IV, met to liver, retroperitoneal/para aortic LNs
8/15 - 11/15: folfiri + liver resection
2/16: 14 5FU + avastin & 4 folfiri +avastin
12/16 -2/17 - PA LN removal (5/10 LNs +) & 25 tx radiation
12/17 - PET confirms metastasis to right common illiac node, uptake in PA LNs
14 folfiri + avastin
9/18: Pet progression, left supraclavicular node, biopsy + for mets
Begin folfiri + vectibix
CEA: not useful. 0.9 now
KRAS wild type, MSS