IMMUNOTHERAPY

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Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

IMMUNOTHERAPY

Postby Eleda » Fri Sep 21, 2018 4:17 pm

Has anyone had this test done, and if so was it a successful process, sorry I can't add a link only copy and paste
Adele X

Dear Adele


On Thu, 20 Sep at 12:24 PM , Oncologica Helpdesk <helpdesk@oncologica.net> wrote:

Dear Adele,
Thank you for your request for more information. Here is a brief overview of the Oncofocus® Test and how to request it. I have also attached a leaflet which you may find helpful.

What is Oncofocus?
As you have probably already read, the Oncofocus® test is applicable to rectal cancer and allows us to identify precisely the right targeted therapies/immunotherapies that the patient’s tumour is likely to respond to on the basis of the DNA mutations present in the tumour.
This is called personalised medicine or precision oncology. Targeted therapies are new drugs that specifically hit cancer cells and not the normal cells of the body. This means they can be much more effective than chemotherapy and do not have the associated severe toxic side effects such as hair loss, infections, anaemia, gut toxicity and fatigue. Most targeted therapies are taken as an oral pill and therefore do not need hospital based infusions. We have now updated the Oncofocus® Test to enable us to match the unique mutation profile of the tumour covering 505 genes linked to 770 targeted therapies including immunotherapy. Oncofocus® is able to identify additional treatment options in 90% of patients. I have attached a technical overview with more in depths information including a sample report for your reference.
The Test Request Process
The test request process is really easy and can be requested directly by the patient. Oncofocus® uses the routine pathology biopsy block that has been used to make the initial diagnosis (held at the hospital where the biopsy was taken) and the patient does not require any further tests or consultations.
The cost is €2000 and this includes both the Oncofocus® Test and the Immunofocus (PD-L1) Test and can be ordered by either completing the attached forms and returning to us at patientcare@oncologica.com or by going to our website at http://www.oncologica.com/request-oncofocus-test and using the ‘request a test’ tab.
We will ask you to provide details of the patient and the hospital(s) they have been treated at. We then request the histopathology reports from the hospital(s) which our consultant pathologist will assess and select suitable samples for testing. We arrange for the collection of the sample and shipment to our laboratories. Once we receive both the sample and payment, the test takes 10 working days and a report will be issued indicating the therapies that have been identified as appropriate.
I have attached a Test Request Form. Should you have any further questions please do not hesitate to contact me and I can arrange for you to speak to a member of the clinical team if you wish.
Kind regards
Kitty Williams RN
Oncologica Clinical Team
BELOW ARE SOME ADDITIONAL LINKS WHICH YOU MAY FIND INFORMATIVE
> UK CHIEF MEDICAL OFFICER CALLS GENE TESTING A REVOLUTION
> VIDEO TALK ON "THE REVOLUTION IN CANCER TREATMENTS"
Need help before ordering?
Call +44 (0) 1223 785327
Want to read more?
Download Oncofocus Brochure
Want to apply for a test online?
Request a test now
http://www.oncologica.com | UK +44 (0) 1223 785327 - IRELAND +353 1 8604204
Oncologica Uk ltd.
Suite 15-16, The Science Village, Chesterford Research park, Cambridge, CB10 1X
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

NHMike
Posts: 1725
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNOTHERAPY

Postby NHMike » Fri Sep 21, 2018 7:10 pm

Hello Adele,

There are likely two services here: one that determines whether or not you are MSI-High or not. People that are MSI-High are generally good candidates for Immunotherapy drugs like Keytruda and Opdivo. The other test is a standard next-gen genomic tumor analysis. They will request your biopsy block and run a next-gen sequencing testing it for known cancer mutations so that you will know exactly what your cancer mutation is. Some people do have more than one mutation too.

The vast majority of mutations probably won't work with immunotherapy as it exists today. There are clinical trials using immunotherapy drugs for non-MSI-High patients. There is a clinical trial at the National Cancer Institute in Baltimore for KRAS G12D and KRAS G12V mutations but I think that the patient has to have specific alleles for it to work.

I asked my oncologist to do the second test and he ignored me. Insurance doesn't cover the cost in the US and I think that the vast majority of cancer patients don't have it done. But I had it done and found out that I'm KRAS G12D but I'm not stage 4 so I probably wouldn't have been accepted into the clinical trial because there's a standard course of therapy for stage 3s. I think that the reason that insurance doesn't cover the latter test is that it doesn't make a difference in treatment for the vast majority of people.

Some of the things that I've written are from memory and may be a little dated. But I think that these are the salient things. You might ask your oncologist on whether or not you should get this test or if it's recommended. I personally think that everyone should know but it's a big out of pocket cost for most people.

The benefit of immunotherapy treatment is that it goes after only the cancer cells. Traditional therapies go after all of your cells and sometimes the removal of parts of your body. I've been through the treatment and if there were an immunotherapy solution, I would have been very happy to accept it.

michael
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: IMMUNOTHERAPY

Postby Eleda » Tue Sep 25, 2018 4:22 am

Thanks so much for Ur reply Mike,
I'm n the middle of standard chemo so won't prob change anything now but in the event this returned as reacurance or matastasis, I would possibly be in a better position for treatment, or trials " all depends on available drugs too I suppose in Ireland at that time !!!
I've had the standard testing and I'm MMR intact!!!!
TBH, one article will say MSS, h is better prognosis than MSS , it just totally confuses me when it comes to mutation,,,,, I don't think my inshurance in Ireland will cover this but I'll pay the 2k myself, as u say, if a choice given , targeted therapy it's a deffo, in saying that I can't complain I'm doing ok through chemo ATM, (4 left)
Even though I'm really pro active and positive,,, I will always be aware that it could return, so anything to prepare or help, I'll do
I'm concidering getting my reversal before X mas, and my surgeon said I would possibly have more evecuation problems rather than incontinence issue's because he tried to make my new rectum perfect size ( but that's wishful thinking lol) but went on the smaller side rather than larger!!!!

Did Ur surgeon give u any indication as to what you were likely to suffer in relation to reversal???
Thanks
Adele x
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

NHMike
Posts: 1725
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNOTHERAPY

Postby NHMike » Tue Sep 25, 2018 6:30 am

Eleda wrote:Thanks so much for Ur reply Mike,
I'm n the middle of standard chemo so won't prob change anything now but in the event this returned as reacurance or matastasis, I would possibly be in a better position for treatment, or trials " all depends on available drugs too I suppose in Ireland at that time !!!
I've had the standard testing and I'm MMR intact!!!!
TBH, one article will say MSS, h is better prognosis than MSS , it just totally confuses me when it comes to mutation,,,,, I don't think my inshurance in Ireland will cover this but I'll pay the 2k myself, as u say, if a choice given , targeted therapy it's a deffo, in saying that I can't complain I'm doing ok through chemo ATM, (4 left)
Even though I'm really pro active and positive,,, I will always be aware that it could return, so anything to prepare or help, I'll do
I'm concidering getting my reversal before X mas, and my surgeon said I would possibly have more evecuation problems rather than incontinence issue's because he tried to make my new rectum perfect size ( but that's wishful thinking lol) but went on the smaller side rather than larger!!!!

Did Ur surgeon give u any indication as to what you were likely to suffer in relation to reversal???
Thanks
Adele x


No indication on how hard things would be after the reversal. She told me afterwards but I found out anyways. I think a lot of people would delay it if they knew how rough it could be.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: IMMUNOTHERAPY

Postby Eleda » Tue Sep 25, 2018 6:43 am

No time is a good time I think, I will make a decision end of next month,,,,
He said he would also do a coplasty, I Never asked if he actually did not the end!!!!! I will next visit!!!! A J- pouch was not an option due to location.
Did u have either done during surgery???
Adele
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

NHMike
Posts: 1725
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNOTHERAPY

Postby NHMike » Tue Sep 25, 2018 7:37 am

Eleda wrote:No time is a good time I think, I will make a decision end of next month,,,,
He said he would also do a coplasty, I Never asked if he actually did not the end!!!!! I will next visit!!!! A J- pouch was not an option due to location.
Did u have either done during surgery???
Adele


I didn’t have either of those done. Just the ileostomy takedown and port removal.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

henry123
Posts: 136
Joined: Sun Oct 08, 2017 3:25 am

Re: IMMUNOTHERAPY

Postby henry123 » Tue Sep 25, 2018 2:35 pm

The only important test right now for you is msi-high vs mss status as only that would alter course of treatment from chemo to possibly immunotherapy from a very good lab.
Other test is not really that useful but if u can comfortably afford it , no harm.
My oncologist said it was a waste of resources when they are most needed due to expenses and reduced income.
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
msi-h Lynch
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes , new onset of multi nodules in liver.
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver normal
1/18 3.6
2/18 2.3
4/18 2.0
opdivo continue
Aspirin start
6/18 1.5 CT clear
8/18 1.3
NED
Vegan yoga juicing apricot

NHMike
Posts: 1725
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNOTHERAPY

Postby NHMike » Tue Sep 25, 2018 2:55 pm

henry123 wrote:The only important test right now for you is msi-high vs mss status as only that would alter course of treatment from chemo to possibly immunotherapy from a very good lab.
Other test is not really that useful but if u can comfortably afford it , no harm.
My oncologist said it was a waste of resources when they are most needed due to expenses and reduced income.


The Genomic Tumor Test is useful for cancers where there is a targeted drug. A coworker with lung cancer went to Dana Farber and they did the test and determined that they had a drug and he's alive over two years later. He likely would have died about two years ago with the test. It's useful if you have one of two mutations and have alleles so that you can try the NCI trial. But that's a small percentage of cases. It's useful if you have an aggressive mutations so that your doctors are aware that it can potentially grow and spread quickly. But that also is a small percentage.

I think that it will be far more useful in the future as more targeted drugs and cure processes are developed. But that's off into the future.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: IMMUNOTHERAPY

Postby Eleda » Tue Sep 25, 2018 4:54 pm

All I know on my cancer is that it's poorly differentiated carcinoma which to me suggest it's an agressive cancer. ( I'm up for correction)
But MMR INTACT suggests different to me so it's very confusing
Someone has to b n the small minority, which at 47 with colorectal cancer is not the majority, so while it may not benefit me to an extent, shurly peace of mine that Ur doing the right thing is worth it to b tested pictullarly in relation to observation/ monitoring over the next few years??
I went to my oncologist today with a swollen underarm lymph and the understudy said that rectal cancer rarely jumps to the breast!!! ( I'm aware of this) but who's to say u can't have a totally unrelated cancer??? It's very possible ( unfortunate yes but very possible)
My mam just had hormone driven breast cancer!!!
So I always feel I'm n the minority!!!!!
Am I looking too much into this ?????
I don't want to keep wondering all the time

Thanks Adele X
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

NHMike
Posts: 1725
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNOTHERAPY

Postby NHMike » Tue Sep 25, 2018 9:47 pm

The science for these individual things is complicated though it's a bit easier if you take one thing at a time.

Mismatch Repair genes are the body's mechanism for automatically fixing damaged genes. Some people don't have them or have them all so they are more susceptible to getting cancer. The two immunotherapy drugs Keytruda and Opdivo help people without one or more of the MMR genes - they are considered MSI-High. There are clinical trials with those drugs for those without MIS-High but I haven't followed how they are going.

I can just ask my son as he works in this area and he can read papers and dumb it down for me or sometimes he knows it off the top of his head. I have spent a lot of time reading papers though.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: IMMUNOTHERAPY

Postby Eleda » Wed Sep 26, 2018 5:20 am

Thanks Mike Ur always very good to explain stuff,
Sorry if This sounds stupid but surely if Ur MMR is intact, u wouldn't have cancer in the first place?? I'm similar to u in the sense I keep reading papers but I'm getting nowhere, ( chasing my tail ) and unfortunately I usually see the understudy at the clinic,,, so it's difficult to get them to break this down to English for me!!!

Also by any chance to u have a reputable link for PSK, I'm aware the Chinese and Japanese will Excel in this area but when it comes to health supplement, I'm Very apprehensive to order from an unknown source outside of Europe, want to start and continue on this along with the cemitidine long term
Thanks again Adele
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: IMMUNOTHERAPY

Postby Eleda » Wed Sep 26, 2018 5:23 am

Henry123
I'm hoping my health insurance will cover this because the hospital said they will test but later down the he line,,
Which make no sense to me what so ever,,,
Why not do it first???
And because I wasn't aware of any of this prior to DX, it takes a long time to grasp the situation and also the mechanism of cancer,,,,
It's not one size fits all anymore
R u n the UK??
ADELE X
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

NHMike
Posts: 1725
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNOTHERAPY

Postby NHMike » Wed Sep 26, 2018 5:25 am

Eleda wrote:Thanks Mike Ur always very good to explain stuff,
Sorry if This sounds stupid but surely if Ur MMR is intact, u wouldn't have cancer in the first place?? I'm similar to u in the sense I keep reading papers but I'm getting nowhere, ( chasing my tail ) and unfortunately I usually see the understudy at the clinic,,, so it's difficult to get them to break this down to English for me!!!

Also by any chance to u have a reputable link for PSK, I'm aware the Chinese and Japanese will Excel in this area but when it comes to health supplement, I'm Very apprehensive to order from an unknown source outside of Europe, want to start and continue on this along with the cemitidine long term
Thanks again Adele


The folks that don't have MMR are the ones that can get cancer when they are fairly young. It seems like there are many paths to getting cancer given all of the known mutations.

I'm not familiar with PSK.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Eleda
Posts: 175
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: IMMUNOTHERAPY

Postby Eleda » Wed Sep 26, 2018 5:41 am

This is just one of the links Mike,,, there are may including an endorsement from MSK


https://www.cancerguide.org/psk.html

https://www.mskcc.org/cancer-care/integ ... versicolor
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

Tupelo honey
Posts: 22
Joined: Tue Jul 19, 2016 7:57 pm

Re: IMMUNOTHERAPY

Postby Tupelo honey » Wed Sep 26, 2018 12:29 pm

I used Mushroom Science PSK. Supposed to be the hot water extract process which is the one used in testing.
So far, so good. I took it throughout chemotherapy.
https://mushroomscience.com/coriolus-super-strength/
Rectal Cancer Stage 3A 10-22-2015 T2N1M0
Start Chemo radiation 11/2015
LAR TME w/ total hysterectomy 3/14/2016 pT2N1M0 No ileo, straight connect
Start Xelox 4/21/16 1 week on/1 week off
Switch to Xelox 2 weeks on/1 week off 6/1/2016
Supplements: Curcumin, PSK, Celixicob, Cimetidime, Glutamine, L-Acytel Carnitine, Vit D, Vit B6, Vit B12, magnesium, calcium, aspirin, metformin, modified citrus pectin
10/2016 NED
03/2017 NED
07/2017 NED
11/2017 NED
05/2018 NED


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