Anyone with Kras and her2 mutations?

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Anyone with Kras and her2 mutations?

Postby supportingsister » Thu Sep 20, 2018 9:58 am

My sister was officially rejected for the hai pump at msk yestwrsay because of a 3mm nodule in her lung. She has several under 1cm mets on her liver that responded poorly to the last round of chemo.

She has a Kras and Her2 mutation. According to dr Epstein, it disqualified her for several current clinical trials. I’ve been looking at dr Lin and the adapt protocol and maybe Md Anderson?

Any suggestions on next steps and who to talk to are appreciated.

I’ll add a signature today to better understand her history. But right now Im looking for oncologists who are aggressive and are good with atypical mutations

Thank you

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Joined: Fri Jul 21, 2017 3:43 am

Re: Anyone with Kras and her2 mutations?

Postby NHMike » Thu Sep 20, 2018 2:43 pm

This is the only HER2 clinical trial that I found.

http://targetedcancercare.massgeneral.o ... extID=2887
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

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Joined: Mon Jun 13, 2011 1:13 am

Re: Anyone with Kras and her2 mutations?

Postby rp1954 » Fri Sep 21, 2018 1:07 pm

I replied to your PM but it is unopened.

There are a lot of lab studies that show various flavonoids reduce overexpression of ErbB2/HER2 in cancer cells and related pathways, or killing them, mostly for breast cancer. For over sixty years there has been been argumentation between ascorbate and flavonoids purists about vitamin C and cancer. My answer is well duh, use them all in their cheapest forms in sensitive cells.

In some papers, flavonoids and vitamin C are shown re-sensitizing CRC to 5FU, including real patients. Vitamin C is published as a KRAS/BRAF cell killer. In real life we found we needed 5FU-LV and Vitamin C + K2. We have been using various flavonoids since the beginning. I might advocate (at least) 1-2 of the highest strength cap for each flavonoid you choose (can find or swallow), half dozen or more flavonoids. Perhaps 3-5 core flavonoids, like EGCG, quercetin, curcumin, silymarin, resveratrol, and 2-3 rotating ones, perhaps depending on supplies and availablity or even specials.

I think Dr. Lin's ADAPT work is important with some great results (e.g. stage IV patients starting ~20 years ago with median OS over 8 years), but needs more. We definitely didn't stop for addons to oral 5FU and celecoxib(Celebrex) rather padding out, carefully selecting and testing from the Life Extension lists of off label drugs and high potency supplements. Best of all about virtual (self) trials, enrollment always seems to be open and treatments flexible, less argument with insurance (for low cost cash items, out of pocket anyway).
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now mostly IV C & no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018

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