FOLFIRI side effects, horrible 4th tx

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FOLFIRI side effects, horrible 4th tx

Postby CLD » Fri Sep 14, 2018 5:46 pm

My husband completed his 4th FOLFIRI + Avastin this week. He tolerated the other 3 *ok* but is having an exceptionally hard time this time. His main complaint and my main question concern his intense rectal burning. He said his guts, genitals, and especially his anus feel like they are on fire. He writhes like he is having what I call *man contractions* despite reviving a double dose of atropine at the infusion center. His urine is dark brown/Orange and he said it *feels weird* leaving his urethra, and he had 1 *skin colored* bowel movement. His hands and feet itch, he's had a constant headache, and he is just...well, depleated. Any help or suggestions appreciated, and thank you in advance.
Wife to DH/ Father of 6 (age 42 at dx) diagnosed Jan 2015 stage IIIC
Tumor deposit in mesentery 13/24 lymph nodes +
CEA at dx: 5
Low Grade/Mod. Diff.
FOLFOX 6 months
N.E.D until June 2018
PET Scan 6/18
Biopsy confirms cancer in 3 Paraaortic lymph nodes BRAF / KRAS negative
Folfiri and Avastin Aug 2018
CEA:2.9 at recurrence

Posts: 72
Joined: Sat Nov 28, 2015 11:45 am
Location: New Brunswick, Canada

Re: FOLFIRI side effects, horrible 4th tx

Postby cbsmith » Fri Sep 14, 2018 7:35 pm

That could be a gall stone or something blocking a bile duct. I had a gallstone a couple years ago in between treatments and my urine was a dark orange color and my stool almost a gray color. Luckily it passed on its own in a couple days and things returned to normal. I did see my oncologist because of it and she said it was a serious issue and needs to be checked as it can cause serious infection.

This may not be what he has but some of the symptoms sound the same. I also had back pain.
06/14-DX with FAP as 36yo Male
07/14-total colectomy, rectum removal, permanent ileostomy
08/14-DX Stage IIIC colon cancer KRAS mutant, MSS
09/14-12 rounds of FOLFOX
04/15-ended FOLFOX
07/15-CT showed one para-aortic lymph node, onc thought inflammation and said wait 3 mths
10/15-DX Stage IV, CT showed lymph node tripled in size and 1 small lung met
11/15-FOLFIRI + Avastin
06/16-lymph node is stable, now have a 2nd lung met
01/16-lymph node is stable, lung mets grown 2mm. Still on FOLFIRI + Avastin

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O Stoma Mia
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Re: FOLFIRI side effects, horrible 4th tx

Postby O Stoma Mia » Fri Sep 14, 2018 9:28 pm

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Joined: Tue Nov 21, 2017 3:48 pm

Re: FOLFIRI side effects, horrible 4th tx

Postby martd » Sun Sep 16, 2018 3:48 pm

I don't have any experience with folfri I was on folfox with avastin with no major side effects. What you described could be serious. How is he doing now, better hopefully. Have you contacted your oncologist? I would definitely report that side effect . Are they doing blood work at his infusion? His liver numbers could be down.

49 y/o male dx 11/2017 crc
Stage 4 with 17 liver Mets, cea 490
12 rounds folfox , avastin / oxi
5/18 cea 2.8 liver resection and pve
7/18 part 2 liver resection, remove right side of liver
Surgical site mrsa infection, wound vac
8/18 cea .9 cCR, rectal tumor is gone
Rectal surgery postponed, watch and wait
10/18 clear scan CEA .7

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