Math Wizards-Xeloda (pills) vs 5FU (pump)

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Math Wizards-Xeloda (pills) vs 5FU (pump)

Postby sdino » Wed Aug 22, 2018 2:53 pm

Ok so standard care on Xeloda is 2 weeks on and 1 week off. Say if you take Xeloda from Monday and end 2 weeks later on a Monday, How long does it take during the off week that Xeloda vacates your system ? 5FU pump half life is just a few hours, BUT how long is the pill form remain in your system ? and … The Pills half life ?
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-2.3CM
MSS, KRAS-mutG12D; TP53
Xeloda+Avastin 11/16 to 1/8/17
CT Scans: 5/17 colon & lung met shrinkage,11/17 to 7/19 slight progression
iTCR TIL Trial NCT03412877 4/19 to 5/19 Off trial, - Sept. 2019 doing Original TIL trial NCT01174121
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Re: Math Wizards-Xeloda (pills) vs 5FU (pump)

Postby peanut_8 » Wed Aug 22, 2018 3:37 pm

female, diagnosed Jan 14, RC stage 2a, age 56
April 14, 28 chemo/rad with Xeloda
June 14 adjuvant Xeloda 6 rounds
currently NED

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Re: Math Wizards-Xeloda (pills) vs 5FU (pump)

Postby margiej » Wed Aug 22, 2018 3:49 pm

I think my ability to comprehend complex material has deteriorated (chemo brain?), but it sure felt like the capecitabine stayed in my system a LONG time. I felt quite ill for a solid 7 days until it was time to start the whole dang cycle again. We postponed the start of the next cycle by a day or two a couple times to help me recover and try to get my fluids back up.
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/17
CT 10/3/17 clear
CT 10/17/18 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

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Re: Math Wizards-Xeloda (pills) vs 5FU (pump)

Postby betsydoglover » Wed Aug 22, 2018 6:51 pm

Xeloda (capecitabine) has a pretty short half life. However, just because it is eliminated relatively rapidly, does not mean you should expect no side effects after that time. The drug has already "worked" and the side effects are a result of it's action. So, side effects continue for quite a while.
diag. Stage IV, 5/05, liver met
lap sigmoid colectomy, 6/05
6 cycles Xeloda/oxaliplatin/Avastin (NED after 2)
11/08 9x13mm right lower lobe lung nodule; removed via VATS 4/09
6 cycles Xeloda + Avastin
Avastin only 10/09-5/11
Still NED 06/18

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